Chan, Jean L.

Recombinant human leptin in women with hypothalamic amenorrhea

Welt, C. K., Chan, J. L., Bullen, J., Murphy, R., Smith, P., DePaoli, A. M., Karalis, A., & Mantzoros, C. S. (2004) · New England Journal of Medicine

Hypothalamic control of reproductive hormonesRegulation of Appetite and Obesity

Cited by 908

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

Chan, J. L., Heist, K., DePaoli, A. M., Veldhuis, J. D., & Mantzoros, C. S. (2003) · Journal of Clinical Investigation

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 697

Leptin and reproduction: a review

Moschos, S., Chan, J. L., & Mantzoros, C. S. (2002) · Fertility and Sterility

Hypothalamic control of reproductive hormonesRegulation of Appetite and Obesity

Cited by 557

Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa.

Chan, J. L., & Mantzoros, C. S. (2005) · The Lancet

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 382

Sleep Loss Reduces Diurnal Rhythm Amplitude of Leptin in Healthy Men

Mullington, J. M., Chan, J. L., Van Dongen, H. P. A., Szuba, M. P., Samaras, J., Price, N. J., Meier‐Ewert, H. K., Dinges, D. F., & Mantzoros, C. S. (2003) · Journal of Neuroendocrinology

Regulation of Appetite and ObesitySleep and Wakefulness Research

Cited by 261

Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans.

Chan, J. L., Matarese, G., Shetty, G. K., Raciti, P., Kelesidis, I., Aufiero, D., De Rosa, V., Perna, F., Fontana, S., & Mantzoros, C. S. (2006) · Proceedings of the National Academy of Sciences

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 213

Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy.

Lee, J. H., Chan, J. L., Sourlas, E., Raptopoulos, V., & Mantzoros, C. S. (2006) · The Journal of Clinical Endocrinology & Metabolism

HIV-related health complications and treatmentsAdipokines, Inflammation, and Metabolic Diseases

Cited by 163

Leptin and the Hypothalamic-Pituitary Regulation of the Gonadotropin-Gonadal Axis

Chan, J. L., & Mantzoros, C. S. (2001) · Pituitary

Hypothalamic control of reproductive hormonesRegulation of Appetite and Obesity

Cited by 124

Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions

Scheer, F. A. J. L., Chan, J. L., Fargnoli, J., Chamberland, J., Arampatzi, K., Shea, S. A., Blackburn, G. L., & Mantzoros, C. S. (2010) · Diabetologia

Adipokines, Inflammation, and Metabolic DiseasesCircadian rhythm and melatonin

Cited by 77

Leptin Does Not Mediate Short-Term Fasting-Induced Changes in Growth Hormone Pulsatility but Increases IGF-I in Leptin Deficiency States

Chan, J. L., Williams, C. J., Raciti, P., Blakeman, J., Kelesidis, T., Kelesidis, I., Johnson, M. L., Thorner, M. O., & Mantzoros, C. S. (2008) · The Journal of Clinical Endocrinology & Metabolism

Growth Hormone and Insulin-like Growth FactorsRegulation of Appetite and Obesity

Cited by 75

Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy

Chan, J. L., Koda, J., Heilig, J. S., Cochran, E. K., Gorden, P., Oral, E. A., & Brown, R. J. (2016) · Clinical Endocrinology

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 72

Short-term fasting-induced autonomic activation and changes in catecholamine levels are not mediated by changes in leptin levels in healthy humans

Chan, J. L., Mietus, J. E., Raciti, P. M., Goldberger, A. L., & Mantzoros, C. S. (2007) · Clinical Endocrinology

Regulation of Appetite and ObesityHeart Rate Variability and Autonomic Control

Cited by 68

Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess.

Chan, J. L., Bullen, J., Stoyneva, V., DePaoli, A. M., Addy, C., & Mantzoros, C. S. (2005) · The Journal of Clinical Endocrinology & Metabolism

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 60

Recombinant Methionyl Human Leptin Administration Activates Signal Transducer and Activator of Transcription 3 Signaling in Peripheral Blood Mononuclear Cells in Vivo and Regulates Soluble Tumor Necrosis Factor-α Receptor Levels in Humans with Relative Leptin Deficiency

Chan, J. L., Moschos, S. J., Bullen, J., Heist, K., Li, X., Kim, Y.-B., Kahn, B. B., & Mantzoros, C. S. (2005) · The Journal of Clinical Endocrinology & Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 56

Crinecerfont Lowers Elevated Hormone Markers in Adults With 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia

Auchus, R. J., Sarafoglou, K., Fechner, P. Y., Vogiatzi, M. G., Imel, E. A., Davis, S. M., Giri, N., Sturgeon, J., Roberts, E., Chan, J. L., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 55