Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions
Open accessAbstract
Aims/hypothesis Adiponectin and lipocalin-2 are adipocyte-derived plasma proteins that have been proposed to have opposite effects on insulin sensitivity. Given the epidemiological, physiological and molecular links between sleep, the circadian timing system and glucose metabolism, the aim of this study was to assess effects of the sleep/wake cycle and the fasting/feeding cycle on high-molecular-weight adiponectin (HMW-adiponectin; the biologically active form) and lipocalin-2. We also aimed to compare the 24 h rhythms in the levels of these proteins with those of cortisol, leptin, leptin-binding protein and total adiponectin.Methods Lean men underwent a 3 day in-laboratory study, either in the fed state (n = 8, age: 20.9 ± 2.1 years, BMI: 22.8 ± 2.3 kg/m²) or fasting state (3 day fast, n = 4, age: 25.3 ± 3.9 years, BMI: 23.3 ± 2.2 kg/m²). The sleep episode was scheduled in darkness from 23:00 to 07:00 hours. Blood was sampled every 15 min for 24 h on the third day of each study.Results While fed, HMW-adiponectin and lipocalin-2 had large daily rhythms with troughs at night (HMW-adiponectin: ~04:00 hours, peak-to-trough amplitude 36%, p < 0.0001; lipocalin-2: ~04:00 hours, 40%, p < 0.0001). On the third day of fasting, the timing and relative amplitudes were unchanged (HMW-adiponectin: ~04:00 hours, 38%, p = 0.0014; lipocalin-2: ~05:00 hours, 38%, p = 0.0043).Conclusions/interpretation These data show that HMW-adiponectin and lipocalin-2 both have significant day/night rhythms, both with troughs at night, that these are not driven by the feeding/fasting cycle, and that it is important to report and/or standardise the time of day for such assays. Further studies are required to determine whether the daily rhythm of HMW-adiponectin levels influences the daily rhythm of insulin sensitivity.
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Adiponectin displays some diurnal variability, with lower levels at night.
“Finally, adiponectin displays some diurnal variability, with lower levels at night (Fig. 2).68,69”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [68]
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- Authors
- Scheer, F. A. J. L., Chan, J. L., Fargnoli, J., Chamberland, J., Arampatzi, K., Shea, S. A., Blackburn, G. L., & Mantzoros, C. S.
- Affiliations
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Scheer, F. A. J. L.
- Venue
- Diabetologia
- Published
- 2010-08-12
- Volume
- 53
- Issue
- 11
- Pages
- 2401-2405
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- PMC
- PMC3111077
- OpenAlex
- W1976458121
- Cited by
- 77
- References
- 13
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- FWCI
- 5.12
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- journal article
- Language
- en
- Open access
- bronze
- doi.org
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- Diabetologia (publishedVersion)
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- Funders
- Brigham and Women's Hospital
- Harvard Catalyst (UL1-RR025758, RR025758, M01-RR-01032)
- National Institutes of Health (DK58785)
- National Heart, Lung, and Blood Institute (K24HL076446, P30HL101299)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK079929, DK-081913, R01DK058785, R56DK058785, DK 79929, DK 58785, K24DK081913, P30DK040561)
- National Center for Research Resources (M01-RR-01032, M01RR001032, UL1RR025758)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- high molecular weight adiponectin, neutrophil gelatinase-associated lipocalin, circadian rhythm, diurnal variation, fasting, feeding state, sleep-wake cycle, cortisol, leptin, adipokines, insulin sensitivity, healthy men, glucose metabolism
- MeSH terms
- Adult, Circadian Rhythm, Enzyme-Linked Immunosorbent Assay, Fasting, Humans, Male, Molecular Weight, Adiponectin, Lipocalins, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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