Cited by 382Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesEating Disorders and Behaviors

Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa.

Chan, Jean L, Mantzoros, Christos S·2005·The Lancet

Abstract

Leptin is an adipocyte-secreted hormone that plays a key part in energy homoeostasis. Advances in leptin physiology have established that the main role of this hormone is to signal energy availability in energy-deficient states. Studies in animals and human beings have shown that low concentrations of leptin are fully or partly responsible for starvation-induced changes in neuroendocrine axes, including low reproductive, thyroid, and insulin-like growth factor (IGF) hormones. Disease states such as exercise-induced hypothalamic amenorrhoea and anorexia nervosa are also associated with low concentrations of leptin and a similar spectrum of neuroendocrine abnormalities. We have recently shown in an interventional, proof-of-concept study that leptin can restore ovulatory menstrual cycles and improve reproductive, thyroid, and IGF hormones and bone markers in hypothalamic amenorrhoea. Further studies are warranted to establish the safety and effectiveness of leptin for the infertility and osteoporosis associated with hypothalamic amenorrhoea, and to clarify its role in anorexia nervosa.

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Crossref · 10.1016/s0140-6736(05)66830-4

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165 of 165 references verified0 citation errors · 0 not checkable

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  • Obese subjects appear either tolerant or resistant to the central hypothalamic effects of leptin.

    “However, although obese subjects are hyperleptinemic compared with lean persons (11), they appear either to be tolerant or resistant to the central hypothalamic effects of leptin.”

    From Leptin in humans: lessons from translational research (2009) · cites this paper as [9]

  • Leptin concentrations are positively correlated with the amount of body fat.

    “Leptin concentrations are positively correlated with the amount of body fat (4-10).”

    From Leptin in humans: lessons from translational research (2009) · cites this paper as [9]

  • In states of secondary failure of the HPG axis associated with loss of fat mass, such as exercise-induced amenorrhea or anorexia nervosa, exogenously administered leptin may fully normalize function of this axis.

    “Moreover, in states of secondary failure of the HPG axis associated with loss of fat mass, such as in exercise-induced amenorrhea or anorexia nervosa, exogenously administered leptin may fully normalize function of this axis (5,7,9,17).”

    From Leptin in humans: lessons from translational research (2009) · cites this paper as [9]

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Authors
Chan, J. L., & Mantzoros, C. S.
Affiliations
Beth Israel Deaconess Medical Center (US)
Corresponding author
Mantzoros, Christos S
Venue
The Lancet
Publisher
Elsevier BV
Published
2005-07
Volume
366
Issue
9479
Pages
74-85
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W2146263588
Cited by
382
References
165
Citations by year
2026: 8 · 2025: 6 · 2024: 13 · 2023: 16 · 2022: 7 · 2021: 15 · 2020: 12 · 2019: 12 · 2018: 15 · 2017: 14 · 2016: 20 · 2015: 15 · 2014: 29 · 2013: 23 · 2012: 17
FWCI
2.40
Type
journal article
Language
en
Open access
closed
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (NIDDK R01 58785)
  • National Center for Research Resources (K23 RR018860)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords
leptin, energy deprivation, hypothalamic amenorrhoea, anorexia nervosa, energy homeostasis, neuroendocrine axis, reproductive hormones, thyroid hormones, insulin-like growth factor, bone turnover markers, leptin therapy, infertility, osteoporosis
MeSH terms
Amenorrhea, Animals, Anorexia Nervosa, Energy Intake, Female, Gonads, Humans, Hypothalamic Diseases, Hypothalamo-Hypophyseal System, Obesity, Pituitary-Adrenal System, Starvation, Leptin

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