Tchkonia, Tamar

New Horizons: Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms

Tchkonia, T., Palmer, A. K., & Kirkland, J. L. (2021) · The Journal of Clinical Endocrinology & Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 129

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., et al. (2019) · Cell Metabolism

Telomeres, Telomerase, and SenescenceNeurogenesis and neuroplasticity mechanisms

Cited by 125

TNF ‐α/ IFN ‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV ‐2 receptor expression via hyper‐activated JAK / STAT1

Kandhaya‐Pillai, R., Yang, X., Tchkonia, T., Martin, G. M., Kirkland, J. L., & Oshima, J. (2022) · Aging Cell

Telomeres, Telomerase, and SenescenceCOVID-19 Clinical Research Studies

Cited by 119

Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases

Gerdes, E. O. W., Zhu, Y. Z., Weigand, B. M., Tripathi, U., Burns, T. C., Tchkonia, T., & Kirkland, J. L. (2020) · International Review of Neurobiology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 114

Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions

Tripathi, U., Misra, A., Tchkonia, T., & Kirkland, J. L. (2021) · Mechanisms of Ageing and Development

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 104

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans

Zhu, Y., Prata, L. G. P. L., Gerdes, E. O. W., Netto, J. M. E., Pirtskhalava, T., Giorgadze, N., Tripathi, U., Inman, C. L., Johnson, K. O., Xue, A., et al. (2022) · EBioMedicine

Telomeres, Telomerase, and SenescenceParathyroid Disorders and Treatments

Cited by 100

BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH

Baboota, R. K., Rawshani, A., Bonnet, L., Li, X., Yang, H., Mardinoglu, A., Tchkonia, T., Kirkland, J. L., Hoffmann, A., Dietrich, A., et al. (2022) · Nature Metabolism

Liver Disease Diagnosis and TreatmentTelomeres, Telomerase, and Senescence

Cited by 99

Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction

Xu, M., Tchkonia, T., & Kirkland, J. L. (2016) · Pharmacological Research

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 99

SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

Tripathi, U., Nchioua, R., Prata, L. G. P. L., Zhu, Y., Gerdes, E. O. W., Giorgadze, N., Pirtskhalava, T., Parker, E., Xue, A., Espindola-Netto, J. M., et al. (2021) · Aging

Telomeres, Telomerase, and SenescenceSARS-CoV-2 and COVID-19 Research

Cited by 88

Transplanting cells from old but not young donors causes physical dysfunction in older recipients

Wang, B., Liu, Z., Chen, V. P., Wang, L., Inman, C. L., Zhou, Y., Guo, C., Tchkonia, T., Rowe, D. W., Kuchel, G. A., et al. (2020) · Aging Cell

Mesenchymal stem cell researchTelomeres, Telomerase, and Senescence

Cited by 76

Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice

Stojakovic, A., Trushin, S., Sheu, A., Khalili, L., Chang, S.-Y., Li, X., Christensen, T., Salisbury, J. L., Geroux, R. E., Gateno, B., et al. (2021) · Communications Biology

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 72

Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

Wang, B., Wang, L., Gasek, N. S., Kuo, C.-L., Nie, J., Kim, T., Yan, P., Zhu, J., Torrance, B. L., Zhou, Y., et al. (2024) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 59

Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing

Gasek, N. S., Yan, P., Zhu, J., Purushothaman, K.-R., Kim, T., Wang, L., Wang, B., Flynn, W. F., Sun, M., Guo, C., et al. (2024) · Nature Aging

Telomeres, Telomerase, and SenescenceWound Healing and Treatments

Cited by 43

Advancing biological understanding of cellular senescence with computational multiomics

Li, S., Agudelo Garcia, P. A., Aliferis, C., Becich, M. J., Calyeca, J., Cosgrove, B. D., Elisseeff, J., Farzad, N., Fertig, E. J., Glass, C., et al. (2025) · Nature Genetics

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 40

Role of senescence in the chronic health consequences of COVID-19

Wissler Gerdes, E. O., Vanichkachorn, G., Verdoorn, B. P., Hanson, G. J., Joshi, A. Y., Murad, M. H., Rizza, S. A., Hurt, R. T., Tchkonia, T., & Kirkland, J. L. (2022) · Translational Research

Telomeres, Telomerase, and SenescenceCOVID-19 Clinical Research Studies

Cited by 38

Markers of cellular senescence are elevated in murine blastocysts cultured in vitro: molecular consequences of culture in atmospheric oxygen

Meuter, A., Rogmann, L.-M., Winterhoff, B. J., Tchkonia, T., Kirkland, J. L., & Morbeck, D. E. (2014) · Journal of Assisted Reproduction and Genetics

Reproductive Biology and FertilityTelomeres, Telomerase, and Senescence

Cited by 36

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

Samakkarnthai, P., Saul, D., Zhang, L., Aversa, Z., Doolittle, M. L., Sfeir, J. G., Kaur, J., Atkinson, E. J., Edwards, J. R., Russell, G. G., et al. (2023) · Aging

Telomeres, Telomerase, and SenescenceBone health and treatments

Cited by 34