Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice
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Abstract
Abstract Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder without a cure. Here we show that mitochondrial respiratory chain complex I is an important small molecule druggable target in AD. Partial inhibition of complex I triggers the AMP-activated protein kinase-dependent signaling network leading to neuroprotection in symptomatic APP/PS1 female mice, a translational model of AD. Treatment of symptomatic APP/PS1 mice with complex I inhibitor improved energy homeostasis, synaptic activity, long-term potentiation, dendritic spine maturation, cognitive function and proteostasis, and reduced oxidative stress and inflammation in brain and periphery, ultimately blocking the ongoing neurodegeneration. Therapeutic efficacy in vivo was monitored using translational biomarkers FDG-PET, 31 P NMR, and metabolomics. Cross-validation of the mouse and the human transcriptomic data from the NIH Accelerating Medicines Partnership–AD database demonstrated that pathways improved by the treatment in APP/PS1 mice, including the immune system response and neurotransmission, represent mechanisms essential for therapeutic efficacy in AD patients.
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Chronic treatment with complex I inhibitor CP2 improves cognitive and motor function in APP/PS1 transgenic mice.
“Chronic treatment with complex I inhibitor, the tricyclic pyrone (CP2), which can penetrate the blood brain barrier (BBB) and accumulate in mitochondria, improves cognitive and motor function in transgenic mice, expressing a form of the amyloid precursor protein (APP) and presenilin 1 that leads to early onset AD (APP/PS1).”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [129]
CP2 treatment reduces total Aβ levels triggering autophagy.
“Further, this treatment can reduce total Aβ levels triggering autophagy, one of the neuroprotective pathways essential for Aβ clearance.”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [129]
CP2 treatment induces multiple protective mechanisms including autophagy, anti-inflammatory, and antioxidant responses, which contribute to reduce Aβ pathology.
“Taken together, the data suggest that CP2 treatment induces multiple protective mechanisms including autophagy, anti-inflammatory, and antioxidant responses, which contribute to reduce Aβ pathology [129].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [129]
Mitochondrial respiratory chain complex I might be a therapeutic target in AD.
“Stojakovic et al. observed that mitochondrial respiratory chain complex I might be a therapeutic target in AD [129].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [129]
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Cites
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
NF-κB signaling in inflammation
Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791 · see citing works
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214 · see citing works
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068 · see citing works
RSeQC: quality control of RNA-seq experiments
Wang, L., Wang, S., & Li, W. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts356 · Cited by 2,813 · see citing works
The role of autophagy in neurodegenerative disease
Nixon, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3232 · Cited by 2,059 · see citing works
Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651 · see citing works
Effects of intermittent fasting on health, aging, and disease
de Cabo, R., & Mattson, M. P. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1905136 · Cited by 1,605 · see citing works
Kind, T., Wohlgemuth, G., Lee, D. Y., Lü, Y., Palazoglu, M., Shahbaz, S., & Fiehn, O. (2009) · Analytical Chemistry · doi:10.1021/ac9019522 · Cited by 1,485 · see citing works
Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386 · see citing works
Structure and function of dendritic spines
Nimchinsky, E. A., Sabatini, B. L., & Svoboda, K. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.160008 · Cited by 1,208 · see citing works
Fat tissue, aging, and cellular senescence
Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094 · see citing works
Self-citationBrain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
Cunnane, S. C., Trushina, E., Morland, C., Prigione, A., Casadesus, G., Andrews, Z. B., Beal, M. F., Bergersen, L. H., Brinton, R. D., de la Monte, S., et al. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0072-x · Cited by 1,003 · see citing works
Self-citationJohnson, E. C. B., Dammer, E. B., Duong, D. M., Ping, L., Zhou, M., Yin, L., Higginbotham, L. A., Guajardo, A., White, B., Troncoso, J. C., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0815-6 · Cited by 1,001 · see citing works
A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease
Panza, F., Lozupone, M., Logroscino, G., & Imbimbo, B. P. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0116-6 · Cited by 965 · see citing works
Xu, M., Tchkonia, T., Ding, H., Ogrodnik, M., Lubbers, E. R., Pirtskhalava, T., White, T. A., Johnson, K. O., Stout, M. B., Mezera, V., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515386112 · Cited by 915 · see citing works
Self-citationReconstruct : a free editor for serial section microscopy
Fiala, J. C. (2005) · Journal of Microscopy · doi:10.1111/j.1365-2818.2005.01466.x · Cited by 884 · see citing works
AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network
Salminen, A., & Kaarniranta, K. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.005 · Cited by 860 · see citing works
Praticò, D., Uryu, K., Leight, S., Trojanoswki, J. Q., & Lee, V. M.-Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04183.2001 · Cited by 777 · see citing works
AMP-activated protein kinase: the current landscape for drug development
Steinberg, G. R., & Carling, D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0019-2 · Cited by 757 · see citing works
Kempadoo, K. A., Mosharov, E. V., Choi, S. J., Sulzer, D., & Kandel, E. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616515114 · Cited by 647 · see citing works
Joshi, A. U., Minhas, P. S., Liddelow, S. A., Haileselassie, B., Andreasson, K. I., Dorn, G. W., & Mochly-Rosen, D. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0486-0 · Cited by 571 · see citing works
Wang, M., Beckmann, N. D., Roussos, P., Wang, E., Zhou, X., Wang, Q., Ming, C., Neff, R., Ma, W., Fullard, J. F., et al. (2018) · Scientific Data · doi:10.1038/sdata.2018.185 · Cited by 502 · see citing works
Campbell, J. M., Bellman, S. M., Stephenson, M. D., & Lisy., K. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.08.003 · Cited by 455 · see citing works
Inhibition of mitochondrial proton F0F1‐ATPase/ATP synthase by polyphenolic phytochemicals
Zheng, J., & Ramirez, V. D. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703397 · Cited by 453 · see citing works
Allen, M., Carrasquillo, M. M., Funk, C., Heavner, B. D., Zou, F., Younkin, C. S., Burgess, J. D., Chai, H.-S., Crook, J., Eddy, J. A., et al. (2016) · Scientific Data · doi:10.1038/sdata.2016.89 · Cited by 439 · see citing works
Self-citationTrushina, E., Dutta, T., Persson, X.-M. T., Mielke, M. M., & Petersen, R. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063644 · Cited by 438 · see citing works
Self-citationExtension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain
Copeland, J. M., Cho, J., Lo, T., Hur, J. H., Bahadorani, S., Arabyan, T., Rabie, J., Soh, J., & Walker, D. W. (2009) · Current Biology · doi:10.1016/j.cub.2009.08.016 · Cited by 409 · see citing works
Cheng, A., Yang, Y., Zhou, Y., Maharana, C., Lu, D., Peng, W., Liu, Y., Wan, R., Marosi, K., Misiak, M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.013 · Cited by 371 · see citing works
Holcomb, L. A., Gordon, M. N., Jantzen, P., Hsiao, K., Duff, K., & Morgan, D. (1999) · Behavior Genetics · doi:10.1023/a:1021691918517 · Cited by 353 · see citing works
Regulation of the pyruvate dehydrogenase complex
Korotchkina, L. G., & Patel, M. S. (2006) · Biochemical Society Transactions · doi:10.1042/bst20060217 · Cited by 330 · see citing works
A review of recent advances in stereology for quantifying neural structure
Mayhew, T. M. (1992) · Journal of Neurocytology · doi:10.1007/bf01191700 · Cited by 330 · see citing works
Rapid Golgi Analysis Method for Efficient and Unbiased Classification of Dendritic Spines
Risher, W. C., Ustunkaya, T., Singh Alvarado, J., & Eroglu, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107591 · Cited by 325 · see citing works
GLUT4 Mobilization Supports Energetic Demands of Active Synapses
Ashrafi, G., Wu, Z., Farrell, R. J., & Ryan, T. A. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.020 · Cited by 320 · see citing works
Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice
Dell'Agnello, C., Leo, S., Agostino, A., Szabadkai, G., Tiveron, C., Zulian, A., Prelle, A., Roubertoux, P., Rizzuto, R., & Zeviani, M. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddl477 · Cited by 308 · see citing works
Regulation of the pyruvate dehydrogenase complex
Patel, M. S., & Korotchkina, L. G. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340217 · Cited by 299 · see citing works
Wan, Y.-W., Al-Ouran, R., Mangleburg, C. G., Perumal, T. M., Lee, T. V., Allison, K., Swarup, V., Funk, C. C., Gaiteri, C., Allen, M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107908 · Cited by 295 · see citing works
Self-citationNeuronal Clearance of Amyloid-β by Endocytic Receptor LRP1
Kanekiyo, T., Cirrito, J. R., Liu, C.-C., Shinohara, M., Li, J., Schuler, D. R., Shinohara, M., Holtzman, D. M., & Bu, G. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3487-13.2013 · Cited by 280 · see citing works
Self-citationPre-Clinical Detection of Alzheimer's Disease Using FDG-PET, with or without Amyloid Imaging
Mosconi, L., Berti, V., Glodzik, L., Pupi, A., Santi, S. D., & de Leon, M. J. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091504 · Cited by 279 · see citing works
Trushina, E. V., Nemutlu, E., Zhang, S., Christensen, T. A., Camp, J. J., Mesa, J., Siddiqui, A., Tamura, Y., Sesaki, H., Wengenack, T. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032737 · Cited by 268 · see citing works
Self-citationIncreased ceramide in brains with Alzheimer's and other neurodegenerative diseases
Filippov, V., Song, M. A., Zhang, K., Vinters, H. V., Tung, S., Kirsch, W. M., Yang, J., & Duerksen-Hughes, P. J. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111202 · Cited by 264 · see citing works
Effects of resveratrol on the rat brain respiratory chain.
Zini, R., Morin, C., Bertelli, A., Bertelli, A., & Tillement, J. P. (1999) · PubMed · Cited by 252 · see citing works
da Silva, S. V., Haberl, M. G., Zhang, P., Bethge, P., Lemos, C., Gonçalves, N., Gorlewicz, A., Malézieux, M., Gonçalves, F. Q., Grosjean, N., et al. (2016) · Nature Communications · doi:10.1038/ncomms11915 · Cited by 240 · see citing works
Brain fluorodeoxyglucose (FDG) PET in dementia
Kato, T., Inui, Y., Nakamura, A., & Ito, K. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.02.003 · Cited by 236 · see citing works
Early Mitochondrial Dysfunction in Long-lived Mclk1+/- Mice
Lapointe, J., & Hekimi, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803287200 · Cited by 207 · see citing works
Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice
Miwa, S., Jow, H., Baty, K., Johnson, A. J., Czapiewski, R., Saretzki, G. C., Treumann, A., & von Zglinicki, T. (2014) · Nature Communications · doi:10.1038/ncomms4837 · Cited by 207 · see citing works
Liu, Y., Yoo, M.-J., Savonenko, A., Stirling, W., Price, D. L., Borchelt, D. R., Mamounas, L., Lyons, W. E., Blue, M. E., & Lee, M. K. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4218-08.2008 · Cited by 206 · see citing works
Self-citationStereological length estimation using spherical probes
Mouton, P. R., Gokhale, A. M., Ward, N. L., & West, M. J. (2002) · Journal of Microscopy · doi:10.1046/j.1365-2818.2002.01006.x · Cited by 203 · see citing works
Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome
Arnold, M., Nho, K., Kueider-Paisley, A., Massaro, T., Huynh, K., Brauner, B., MahmoudianDehkordi, S., Louie, G., Moseley, M. A., Thompson, J. W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14959-w · Cited by 202 · see citing works
Self-citationAltered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease
Zhang, L., Trushin, S., Christensen, T. A., Bachmeier, B. V., Gateno, B., Schroeder, A., Yao, J., Itoh, K., Sesaki, H., Poon, W. W., et al. (2016) · Scientific Reports · doi:10.1038/srep18725 · Cited by 198 · see citing works
Self-citationWeisová, P., Concannon, C. G., Devocelle, M. C., Prehn, J. H. M., & Ward, M. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0354-09.2009 · Cited by 176 · see citing works
Spine neck plasticity controls postsynaptic calcium signals through electrical compartmentalization
Grunditz, Å., Holbro, N., Tian, L., Zuo, Y., & Oertner, T. G. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2702-08.2008 · Cited by 157 · see citing works
Parr, C., Carzaniga, R., Gentleman, S., LEUVEN, F. V., Walter, J., & Sastre, M. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00930-12 · Cited by 155 · see citing works
Baumgart, M., Priebe, S., Groth, M., Hartmann, N., Menzel, U., Pandolfini, L., Koch, P., Felder, M., Ristow, M., Englert, C., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.01.014 · Cited by 147 · see citing works
Sun, Y., Zhou, S., Guo, H., Zhang, J., Ma, T., Zheng, Y., Zhang, Z., & Cai, L. (2019) · Metabolism · doi:10.1016/j.metabol.2019.154002 · Cited by 142 · see citing works
Uddin, M. S., Mamun, A. A., Labu, Z. K., Hidalgo‐Lanussa, O., Barreto, G. E., & Ashraf, G. M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27588 · Cited by 140 · see citing works
Annese, A., Manzari, C., Lionetti, C., Picardi, E., Horner, D. S., Chiara, M., Caratozzolo, M. F., Tullo, A., Fosso, B., Pesole, G., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22701-2 · Cited by 125 · see citing works
Zhang, L., Zhang, S., Maezawa, I., Trushin, S., Minhas, P. S., Pinto, M., Jin, L., Prasain, K., Nguyen, T. D. T., Yamazaki, Y., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.03.009 · Cited by 110 · see citing works
Self-citationGalić, S., Loh, K., Murray‐Segal, L., Steinberg, G. R., Andrews, Z. B., & Kemp, B. E. (2018) · eLife · doi:10.7554/elife.32656 · Cited by 108 · see citing works
A Meta-Analysis of Alzheimer’s Disease Brain Transcriptomic Data
Patel, H., Dobson, R., & Newhouse, S. J. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181085 · Cited by 101 · see citing works
Wengenack, T. M., Whelan, S. L., Curran, G. L., Duff, K., & Poduslo, J. F. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00388-2 · Cited by 97 · see citing works
Raule, N., Sevini, F., Li, S., Barbieri, A., Tallaro, F., Lomartire, L., Vianello, D., Montesanto, A., Moilanen, J. S., Bezrukov, V. V., et al. (2013) · Aging Cell · doi:10.1111/acel.12186 · Cited by 97 · see citing works
Sluggett, J. K., Koponen, M., Bell, J. S., Taipale, H., Tanskanen, A., Tiihonen, J., Uusitupa, M., Tolppanen, A.-M., & Hartikainen, S. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz234 · Cited by 95 · see citing works
Guéguen, N., Desquiret‐Dumas, V., Leman, G., Chupin, S., Baron, S., Nivet‐Antoine, V., Vessières, E., Ayer, A., Henrion, D., Lenaers, G., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144290 · Cited by 93 · see citing works
Cheng, A., Wang, J., Ghena, N., Zhao, Q., Perone, I., King, T. M., Veech, R. L., Gorospe, M., Wan, R., & Mattson, M. P. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1446-19.2019 · Cited by 91 · see citing works
Marinangeli, C., Didier, S., Ahmed, T., Caillerez, R., Domise, M., Laloux, C., Bégard, S., Carrier, S., Colin, M., Marchetti, P., et al. (2018) · iScience · doi:10.1016/j.isci.2018.10.006 · Cited by 87 · see citing works
Kahl, A., Степанова, А., Konràd, C., Anderson, C. J., Manfredi, G., Zhou, P., Iadecola, C., & Galkin, A. S. (2018) · Stroke · doi:10.1161/strokeaha.117.019687 · Cited by 86 · see citing works
Self-citationLocus coeruleus, norepinephrine and Aβ peptides in Alzheimer's disease
Ross, J. A., McGonigle, P., & Bockstaele, E. J. V. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2015.09.002 · Cited by 85 · see citing works
Amyloid-β Increases Tau by Mediating Sirtuin 3 in Alzheimer’s Disease
Yin, J., Han, P., Song, M., Nielsen, M., Beach, T. G., Serrano, G. E., Liang, W. S., Caselli, R. J., & Shi, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0977-0 · Cited by 82 · see citing works
Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer’s Disease
Canchi, S., Raao, B., Masliah, D., Rosenthal, S. B., Šášik, R., Fisch, K. M., Jager, P. L. D., Bennett, D. A., & Rissman, R. A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.073 · Cited by 81 · see citing works
Altered circadian locomotor activity in APP23 mice: a model for BPSD disturbances
Vloeberghs, E., Dam, D. V., Engelborghs, S., Nagels, G., Staufenbiel, M., & Deyn, P. P. D. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03755.x · Cited by 79 · see citing works
Locus (Coeruleus) Minoris Resistentiae in Pathogenesis of Alzheimer’s Disease
Mravec, B., Lejavová, K., & Cubinkova, V. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666141107130505 · Cited by 74 · see citing works
Saito, M., Saito, M., & Das, B. C. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.01.007 · Cited by 73 · see citing works
Inhibition of Alzheimer’s amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo
Hong, H., Rana, S., Barrigan, L. M., Shi, A., Zhang, Y., Zhou, F., Jin, L., & Hua, D. H. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05866.x · Cited by 67 · see citing works
Степанова, А., Kahl, A., Konràd, C., Ten, V. S., Starkov, A. A., & Galkin, A. S. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17730242 · Cited by 65 · see citing works
Self-citationPlasma sphingolipid changes with autopsy‐confirmed Lewy body or Alzheimer's pathology
Savica, R., Murray, M. E., Persson, X.-M. T., Kantarci, K., Parisi, J. E., Dickson, D. W., Petersen, R. C., Ferman, T. J., Boeve, B. F., & Mielke, M. M. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.02.005 · Cited by 51 · see citing works
Dzeja, P. P., Bast, P., Pucar, D., Wieringa, B., & Terzic, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705268200 · Cited by 50 · see citing works
Self-citationHunt, R. J., Granat, L., McElroy, G. S., Ranganathan, R., Chandel, N. S., & Bateman, J. M. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201904148 · Cited by 49 · see citing works
Caberlotto, L., Lauria, M., Nguyen, T.-P., & Scotti, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078919 · Cited by 47 · see citing works
Paek, S. B., Min, H.-K. P., Kim, I., Knight, E. J., Baek, J. J., Bieber, A. J., Lee, K. H., & Chang, S.-Y. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.09.064 · Cited by 46 · see citing works
Self-citationDeconstructing and targeting the genomic architecture of human neurodegeneration
Jager, P. L. D., Yang, H., & Bennett, D. A. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0240-z · Cited by 46 · see citing works
Logsdon, B. A., Perumal, T. M., Swarup, V., Wang, M., Funk, C. C., Gaiteri, C., Allen, M., Wang, X. B., Dammer, E. B., Srivastava, G. P., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/510420 · Cited by 46 · see citing works
Self-citationSyntheses and bioactivities of tricyclic pyrones
Hua, D. H., Huang, X., Tamura, M., et al. (2003) · Tetrahedron · doi:10.1016/s0040-4020(03)00687-2 · Cited by 35 · see citing works
Stojakovic, A., Chang, S.-Y., Nesbitt, J. J., Pichurin, N. P., Ostroot, M., Aikawa, T., Kanekiyo, T., & Trushina, E. V. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-201015 · Cited by 31 · see citing works
Self-citationLiu, Y. M., Lee, M. K., James, M. M., Price, D. L., Borchelt, D., Troncoso, J. C., & Oh, E. S. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101602 · Cited by 16 · see citing works
Self-citationZhang, L., Zhang, S., Maezawa, I., Trushin, S., Minhas, P. S., Pinto, M., Jin, L., Prasain, K., Nguyen, T. D. T., Yamazaki, Y., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.062 · Cited by 9 · see citing works
Self-citationAlzheimer prevention hopes continue to dim
Mullard, A. (2020) · Nature Reviews Drug Discovery · doi:10.1038/d41573-020-00044-w · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [76]Franklin, K. B. J. & Paxinos, G. The Mouse Brain in Stereotaxic Coordinates (Academic Press, Boston, 2008).
Cited by
Sorted by citations
Buccellato, F. R., D’Anca, M., Fenoglio, C., Scarpini, E., & Galimberti, D. (2021) · Antioxidants · doi:10.3390/antiox10091353 · Cited by 179 · see citing works
Axonal energy metabolism, and the effects in aging and neurodegenerative diseases
Yang, S., Park, J. H., & Lu, H.-C. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00634-3 · Cited by 94 · see citing works
- Authors
- Stojakovic, A., Trushin, S., Sheu, A., Khalili, L., Chang, S.-Y., Li, X., Christensen, T., Salisbury, J. L., Geroux, R. E., Gateno, B., Flannery, P. J., Dehankar, M., Funk, C. C., Wilkins, J., Stepanova, A., O’Hagan, T., Galkin, A., Nesbitt, J., Zhu, X., Tripathi, U., Macura, S., Tchkonia, T., Pirtskhalava, T., Kirkland, J. L., Kudgus, R. A., Schoon, R. A., Reid, J. M., Yamazaki, Y., Kanekiyo, T., Zhang, S., Nemutlu, E., Dzeja, P., Jaspersen, A., Kwon, Y. I. C., Lee, M. K., & Trushina, E.
- Affiliations
- Mayo Clinic (US)
- University of Minnesota (US)
- Institute for Systems Biology (US)
- Columbia University Irving Medical Center (US)
- Hacettepe University (TR)
- Corresponding author
- Trushina, Eugenia
- ORCID
- Stojakovic, Andrea
- Trushin, Sergey
- Li, Xing
- Christensen, Trace
- Dehankar, Mrunal
- Funk, Cory C.
- Galkin, Alexander
- Tripathi, Utkarsh
- Macura, Slobodan
- Tchkonia, Tamar
- Pirtskhalava, Tamar
- Kirkland, James L.
- Kudgus, Rachel A.
- Reid, Joel M.
- Yamazaki, Yu
- Kanekiyo, Takahisa
- Zhang, Song
- Nemutlu, Emirhan
- Dzeja, Petras
- Kwon, Ye In Christopher
- Lee, Michael K.
- Trushina, Eugenia
- Venue
- Communications Biology
- Published
- 2021-01-08
- Volume
- 4
- Issue
- 1
- Pages
- 61-61
- ISSN
- 2399-3642 (ISSN-L)
- PMC
- PMC7794523
- OpenAlex
- W3120159357
- Cited by
- 72
- References
- 89
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 10 · 2023: 18 · 2022: 10 · 2021: 9 · 2020: 1
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Update notices
- correction (2024-02-26)
- Open access
- gold
- doi.org
- Locations
- Communications Biology (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Alzheimer’s Drug Discovery Foundation (291204)
- U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS107265)
- U.S. Department of Health & Human Services | NIH | National Institute on Aging (RO1AG062135, RF1AG55549)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, mitochondrial complex I inhibition, APP/PS1 mice, AMPK, neuroprotection, energy homeostasis, synaptic function, long-term potentiation, dendritic spine maturation, proteostasis, oxidative stress, neuroinflammation, cognitive function, mitochondrial respiratory chain
- MeSH terms
- Neuroprotection, Proof of Concept Study, Alzheimer Disease, Animals, Brain, Cognition, Disease Models, Animal, Drug Evaluation, Preclinical, Female, Mice, Inbred C57BL, Mice, Transgenic, Pyrones, Signal Transduction, Electron Transport Complex I, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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