Nova autoregulation reveals dual functions in neuronal splicing

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ADAM15 gene structure and differential alternative exon use in human tissues

Kleino, I., Ortiz, R. M., & Huovila, A. J. (2007) · BMC Molecular Biology · doi:10.1186/1471-2199-8-90 · Cited by 33 · see citing works

Alternative pre-mRNA splicing in the human system: unexpected role of repetitive sequences as regulatory elements

Hui, J., & Bindereif, A. (2005) · Biological Chemistry · doi:10.1515/bc.2005.143 · Cited by 30 · see citing works

RNA-Seq of Human Neural Progenitor Cells Exposed to Lead (Pb) Reveals Transcriptome Dynamics, Splicing Alterations and Disease Risk Associations

Jiang, P., Hou, Z., Bolin, J. M., Thomson, J., & Stewart, R. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx129 · Cited by 27 · see citing works

The bromodomain-containing gene BRD2 is regulated at transcription, splicing, and translation levels

Shang, E., Cui, Q., Wang, X., Beseler, C. L., Greenberg, D. A., & Wolgemuth, D. J. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23192 · Cited by 30 · see citing works

Evolutionarily conserved autoregulation of alternative pre-mRNA splicing by ribosomal protein L10a

Takei, S., Togo‐Ohno, M., Suzuki, Y., & Kuroyanagi, H. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw152 · Cited by 29 · see citing works

Nova1 mediates resistance of rat pheochromocytoma cells to hypoxia-induced apoptosis via the Bax/Bcl-2/caspase-3 pathway

Li, H., Lv, B., Kong, L., Xia, J., Ming, Z., Hu, L., Zhen, D., Wu, Y., Jia, X., Zhu, S., et al. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3089 · Cited by 29 · see citing works

RBM4–Nova1–SRSF6 splicing cascade modulates the development of brown adipocytes

Lin, J.-C., Chi, Y.-L., Peng, H.-Y., & Lu, Y.-H. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.08.006 · Cited by 28 · see citing works

The role of alternative pre-mRNA splicing in cancer progression

Choi, S., Cho, N., Kim, E.-M., & Kim, K. K. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03094-3 · Cited by 27 · see citing works

An isoform-resolution transcriptomic atlas of colorectal cancer from long-read single-cell sequencing

Li, Z., Zhang, B., Chan, J. J., Tabatabaeian, H., Tong, Q. Y., Chew, X. H., Fan, X., Driguez, P., Chan, C., Cheong, F., et al. (2024) · Cell Genomics · doi:10.1016/j.xgen.2024.100641 · Cited by 27 · see citing works

TOX4 and NOVA1 Proteins Are Partners of the LEDGF PWWP Domain and Affect HIV-1 Replication

Morchikh, M., Naughtin, M., Nunzio, F. D., Xavier, J., Charneau, P., Jacob, Y., & Lavigne, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081217 · Cited by 23 · see citing works

Characterization of sequences and mechanisms through which ISE/ISS-3 regulates FGFR2 splicing

Hovhannisyan, R. H. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj407 · Cited by 22 · see citing works

An Integrated Regulatory Network Reveals Pervasive Cross-Regulation among Transcription and Splicing Factors

Kosti, I., Predrag Radivojac, A., & Mandel‐Gutfreund, Y. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002603 · Cited by 20 · see citing works

Functional and Mechanistic Insights From Genome-Wide Studies of Splicing Regulation in the Brain

Ule, J., & Darnell, R. B. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-77374-2_9 · Cited by 21 · see citing works

hnRNPA1 autoregulates its own mRNA expression to remain non-cytotoxic

Suzuki, H., & Matsuoka, M. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2904-x · Cited by 21 · see citing works

Identifying cell state–associated alternative splicing events and their coregulationPreprint

Najar, C. F. B. A., Burra, P., Yosef, N., & Lareau, L. F. (2022) · Genome Research · doi:10.1101/gr.276109.121 · Cited by 21 · see citing works

A humanized NOVA1 splicing factor alters mouse vocal communications

Tajima, Y., Vargas, C. D. M., Ito, K., Wang, W., Luo, J., Xing, J., Kuru, N., Machado, L. C., Siepel, A. C., Carroll, T. S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56579-2 · Cited by 21 · see citing works

Splicing in the Human Brain

Zaghlool, A., Ameur, A., Cavelier, L. B., & Feuk, L. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801105-8.00005-9 · Cited by 20 · see citing works

NOVA1 acts on Impact to regulate hypothalamic function and translation in inhibitory neurons

Tajima, Y., Ito, K., Yuan, Y., Frank, M. O., Saito, Y., & Darnell, R. B. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112050 · Cited by 18 · see citing works

Ab initio identification of functionally interacting pairs of cis-regulatory elementsPreprint

Friedman, B. A., Stadler, M. B., Shomron, N., Ding, Y., & Burge, C. B. (2008) · Genome Research · doi:10.1101/gr.080085.108 · Cited by 17 · see citing works

Dysregulated RNA-binding proteins and alternative splicing: Emerging roles in autism spectrum disorder

Jeong, J., Yoo, H. J., An, J., & Jeong-Yu, S. (2025) · Molecules and Cells · doi:10.1016/j.mocell.2025.100237 · Cited by 15 · see citing works

Disabled-1 Alternative Splicing in Human Fetal Retina and Neural Tumors

Katyal, S., Glubrecht, D. D., Li, L., Gao, Z., & Godbout, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028579 · Cited by 15 · see citing works

mRNA isoform balance in neuronal development and disease

LaForce, G. R., Philippidou, P., & Schaffer, A. E. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1762 · Cited by 14 · see citing works

The hnRNP and cytoskeletal protein raver1 contributes to synaptic plasticity

Lahmann, I., Fabienke, M., Henneberg, B. J. M., Pabst, O., Vauti, F., Minge, D., Illenberger, S., Jockusch, B. M., Körte, M., & Arnold, H.-H. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.10.022 · Cited by 12 · see citing works

The Genetic Control of Stoichiometry Underlying Autism

Darnell, R. B. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-100119-024851 · Cited by 12 · see citing works

Cholinergic regulation of striatal Nova mRNAs

Jelen, N., Ule, J., & Živin, M. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.013 · Cited by 10 · see citing works

Dynamic Expression Pattern of Neuro-oncological Ventral Antigen 1 (Nova1) in the Rat Brain after Focal Cerebral Ischemia/Reperfusion Insults

Li, H., Sun, C., Wang, Y., Gao, Y., Liu, Y., Gao, Y., Xu, L., & Zhang, C. (2012) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155412461255 · Cited by 10 · see citing works

Intronic UGG repeats coordinate splicing of CD44 alternative exons v8 and v9

Galiana-Arnoux, D., Gatto–Konczak, F. D., Gesnel, M.-C., & Breathnach, R. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.153 · Cited by 10 · see citing works

The salmonid myostatin gene family: a novel model for investigating mechanisms that influence duplicate gene fate

Lawson, C. B., Niino, T., Hermansen, R. A., Brok-Volchanskaya, V. S., Jackson, M. F., Garikipati, D. K., Liberles, D. A., & Rodgers, B. D. (2012) · BMC Evolutionary Biology · doi:10.1186/1471-2148-12-202 · Cited by 8 · see citing works

NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells

Saito, Y., Yang, Y., Saito, M., Park, C. Y., Funato, K., Tabar, V. S., & Darnell, R. B. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2314695121 · Cited by 6 · see citing works

Unusual Intron Conservation Near Tissue-regulated Exons Found by Splicing Microarrays

Sugnet, C. W., Srinivasan, K., Clark, T. A., O’Brien, G. S., Cline, M., Wang, H., Williams, A., Kulp, D., Blume, J., Haussler, D. H., et al. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0020004.eor · Cited by 5 · see citing works

Two Faces of Evil: Cancer and Neurodegeneration

Curran, T., & Christen, Y. (2010) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-16602-0 · Cited by 5 · see citing works

FUS ALS-causative mutations impact FUS autoregulation and the processing of RNA-binding proteins through intron retentionPreprint

Humphrey, J., Birsa, N., Milioto, C., Robaldo, D., Eberle, A. B., Kräuchi, R., Bentham, M. P., Ule, A. M., Jarvis, S., Bodo, C., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/567735 · Cited by 5 · see citing works

Alternative Splicing and CaV ‐Associated Channelopathies

Munyao, W., Rahman, M. M., Sabzanov, S., Chu, E. H., Wang, R., Wang, Z., Yu, Y., & Ruggiu, M. (2025) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.70016 · Cited by 4 · see citing works

Nova Regulates GABA A Receptor γ2 Alternative Splicing via a Distal Downstream UCAU-Rich Intronic Splicing Enhancer

Dredge, B. K., & Darnell, R. B. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.13.4687-4700.2003 · Cited by 120 · see citing works

Nova Regulation of Alternative Splicing in the CNS

Dredge, B. K. (2025) · Digital Commons - RU (Rockefeller University) · doi:10.48496/9qj7-0352

Nova-1 Regulates Neuron-Specific Alternative Splicing and Is Essential for Neuronal Viability

Jensen, K. B., Dredge, B. K., Stefani, G., Zhong, R., Buckanovich, R. J., Okano, H. J., Yang, Y. Y. L., & Darnell, R. B. (2000) · Neuron · doi:10.1016/s0896-6273(00)80900-9 · Cited by 426 · see citing works

An RNA map predicting Nova-dependent splicing regulation

Ule, J., Stefani, G., Mele, A., Ruggiu, M., Wang, X., Taneri, B., Gaasterland, T., Blencowe, B. J., & Darnell, R. B. (2006) · Nature · doi:10.1038/nature05304 · Cited by 528 · see citing works

Functional and Mechanistic Insights From Genome-Wide Studies of Splicing Regulation in the Brain

Ule, J., & Darnell, R. B. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-77374-2_9 · Cited by 21 · see citing works