Ganz, Tomas

Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin

Lin, L., Goldberg, Y. P., & Ganz, T. (2005) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 241

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

Preza, G. C., Ruchala, P., Pinon, R., Ramos, E., Qiao, B., Peralta, M. A., Sharma, S., Waring, A., Ganz, T., & Nemeth, E. (2011) · Journal of Clinical Investigation

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 234

Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin.

Valore, E. V., & Ganz, T. (2008) · Blood Cells Molecules and Diseases

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 234

The molecular basis of ferroportin-linked hemochromatosis

De Domenico, I., Ward, D. M., Nemeth, E., Vaughn, M. B., Musci, G., Ganz, T., & Kaplan, J. (2005) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 230

Hepcidin-Induced Hypoferremia Is a Critical Host Defense Mechanism against the Siderophilic Bacterium Vibrio vulnificus

Arezes, J., Jung, G., Gabayan, V., Valore, E., Ruchala, P., Gulig, P. A., Ganz, T., Nemeth, E., & Bulut, Y. (2015) · Cell Host & Microbe

Iron Metabolism and DisordersVibrio bacteria research studies

Cited by 227

Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis

Ramos, E., Ruchala, P., Goodnough, J. B., Kautz, L., Preza, G. C., Nemeth, E., & Ganz, T. (2012) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 213

Hepcidin and Host Defense against Infectious Diseases

Michels, K., Nemeth, E., Ganz, T., & Mehrad, B. (2015) · PLOS Pathogens

Iron Metabolism and DisordersImmune Response and Inflammation

Cited by 205

Effects of maternal iron status on placental and fetal iron homeostasis

Sangkhae, V., Fisher, A. L., Wong, S., Koenig, M. D., Tussing-Humphreys, L., Chu, A., Lelić, M., Ganz, T., & Nemeth, E. (2019) · Journal of Clinical Investigation

Iron Metabolism and DisordersPregnancy and preeclampsia studies

Cited by 198

Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia

Rivera, S., Liu, L., Nemeth, E., Gabayan, V., Sorensen, O. E., & Ganz, T. (2005) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 196

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

Besson-Fournier, C., Latour, C., Kautz, L., Bertrand, J., Ganz, T., Roth, M.-P., & Coppin, H. (2012) · Blood

Iron Metabolism and DisordersTGF-β signaling in diseases

Cited by 179

Urinary hepcidin in congenital chronic anemias

Kearney, S. L., Nemeth, E., Neufeld, E. J., Thapa, D., Ganz, T., Weinstein, D. A., & Cunningham, M. J. (2007) · Pediatric Blood & Cancer

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 172

The Hepcidin-Ferroportin System as a Therapeutic Target in Anemias and Iron Overload Disorders

Ganz, T., & Nemeth, E. (2011) · Hematology

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 172

Reduced serum hepcidin levels in patients with chronic hepatitis C

Girelli, D., Pasino, M., Goodnough, J. B., Nemeth, E., Guido, M., Castagna, A., Busti, F., Campostrini, N., Martinelli, N., Vantini, I., et al. (2009) · Journal of Hepatology

Iron Metabolism and DisordersHepatitis C virus research

Cited by 169

Erythroferrone structure, function, and physiology: Iron homeostasis and beyond

Srole, D. N., & Ganz, T. (2021) · Journal of Cellular Physiology

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 155

Erythroferrone contributes to recovery from anemia of inflammation

Kautz, L., Jung, G., Nemeth, E., & Ganz, T. (2014) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 152

Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project

Piperno, A., Galimberti, S., Mariani, R., Pelucchi, S., Ravasi, G., Lombardi, C., Bilo, G., Revera, M., Giuliano, A., Faini, A., et al. (2011) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 151

Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera

Casu, C., Oikonomidou, P. R., Chen, H., Nandi, V., Ginzburg, Y., Prasad, P., Fleming, R. E., Shah, Y. M., Valore, E. V., Nemeth, E., et al. (2016) · Blood

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 148

Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds

Cole, A. M., Shi, J., Ceccarelli, A., Kim, Y.-H., Park, A., & Ganz, T. (2001) · Blood

Antimicrobial Peptides and ActivitiesWound Healing and Treatments

Cited by 146

Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron

Stefanova, D., Raychev, A., Arezes, J., Ruchala, P., Gabayan, V., Skurnik, M., Dillon, B. J., Horwitz, M. A., Ganz, T., Bulut, Y., et al. (2017) · Blood

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 145

A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin

Kim, A., Fung, E., Parikh, S. G., Valore, E. V., Gabayan, V., Nemeth, E., & Ganz, T. (2014) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 145

Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

Ross, S. L., Tran, L., Winters, A., Lee, K.-J., Plewa, C., Foltz, I., King, C., Miranda, L. P., Allen, J., Beckman, H., et al. (2012) · Cell Metabolism

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 145

In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2

Maes, K., Nemeth, E., Roodman, G. D., Huston, A., Esteve, F., Freytes, C., Callander, N., Katodritou, E., Tussing-Humphreys, L., Rivera, S., et al. (2010) · Blood

Iron Metabolism and DisordersCytokine Signaling Pathways and Interactions

Cited by 132

Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc

Mitchell, C. J., Shawki, A., Ganz, T., Nemeth, E., & Mackenzie, B. (2014) · American Journal of Physiology-Cell Physiology

Iron Metabolism and DisordersTrace Elements in Health

Cited by 132

Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6

Rodriguez, R., Jung, C.-L., Gabayan, V., Deng, J. C., Ganz, T., Nemeth, E., & Bulut, Y. (2014) · Infection and Immunity

Iron Metabolism and DisordersImmune Response and Inflammation

Cited by 127