Ganz, Tomas

Hepcidin and Iron in Health and Disease

Nemeth, E., & Ganz, T. (2023) · Annual Review of Medicine

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 457

Hepcidin in iron overload disorders

Papanikolaou, G., Tzilianos, M., Christakis, J. I., Bogdanos, D., Tsimirika, K., MacFarlane, J., Goldberg, Y. P., Sakellaropoulos, N., Ganz, T., & Nemeth, E. (2005) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 445

The Molecular Mechanism of Hepcidin-mediated Ferroportin Down-Regulation

De Domenico, I., Ward, D. M., Langelier, C., Vaughn, M. B., Nemeth, E., Sundquist, W. I., Ganz, T., Musci, G., & Kaplan, J. (2007) · Molecular Biology of the Cell

Iron Metabolism and DisordersCellular transport and secretion

Cited by 434

Detection, evaluation, and management of iron-restricted erythropoiesis

Goodnough, L. T., Nemeth, E., & Ganz, T. (2010) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 410

Anemia of inflammation

Nemeth, E., & Ganz, T. (2014) · Hematology/Oncology Clinics of North America

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 401

The Solution Structure of Human Hepcidin, a Peptide Hormone with Antimicrobial Activity That Is Involved in Iron Uptake and Hereditary Hemochromatosis

Hunter, H. N., Fulton, D. B., Ganz, T., & Vogel, H. J. (2002) · Journal of Biological Chemistry

Iron Metabolism and DisordersProtein Structure and Dynamics

Cited by 400

Hepcidin—a regulator of intestinal iron absorption and iron recycling by macrophages

GANZ, T. (2005) · Best Practice & Research Clinical Haematology

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 393

Liver iron concentrations and urinary hepcidin in -thalassemia

Origa, R., Galanello, R., Ganz, T., Giagu, N., Maccioni, L., Faa, G., & Nemeth, E. (2007) · Haematologica

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 365

Iron Sequestration and Anemia of Inflammation

Ganz, T., & Nemeth, E. (2009) · Seminars in Hematology

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 361

Molecular control of iron transport

Ganz, T. (2007) · Journal of the American Society of Nephrology

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 353

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

Tanno, T., Porayette, P., Sripichai, O., Noh, S.-J., Byrnes, C., Bhupatiraju, A., Lee, Y. T., Goodnough, J. B., Harandi, O., Ganz, T., et al. (2009) · Blood

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 352

Iron imports. IV. Hepcidin and regulation of body iron metabolism

Ganz, T., & Nemeth, E. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 347

Hepcidin-Induced Endocytosis of Ferroportin Is Dependent on Ferroportin Ubiquitination

Qiao, B., Sugianto, P., Fung, E., del-Castillo-Rueda, A., Moran-Jimenez, M.-J., Ganz, T., & Nemeth, E. (2012) · Cell Metabolism

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 334

Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin

Aschemeyer, S., Qiao, B., Stefanova, D., Valore, E. V., Sek, A. C., Ruwe, T. A., Vieth, K. R., Jung, G., Casu, C., Rivella, S., et al. (2018) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 325

Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs

Rivera, S., Nemeth, E., Gabayan, V., Lopez, M. A., Farshidi, D., & Ganz, T. (2005) · Blood

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 308

Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia

Kautz, L., Jung, G., Du, X., Gabayan, V., Chapman, J., Nasoff, M., Nemeth, E., & Ganz, T. (2015) · Blood

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 306

Iron in innate immunity: starve the invaders

Ganz, T. (2009) · Current Opinion in Immunology

Iron Metabolism and DisordersImmune Response and Inflammation

Cited by 284

Macrophages and Systemic Iron Homeostasis

Ganz, T. (2012) · Journal of Innate Immunity

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 281

The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study

Nemeth, E., Preza, G. C., Jung, C.-L., Kaplan, J., Waring, A. J., & Ganz, T. (2006) · Blood

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 273

Iron and infection

Ganz, T. (2018) · International Journal of Hematology

Iron Metabolism and DisordersHemoglobin structure and function

Cited by 270

Macrophages Acquire Neutrophil Granules for Antimicrobial Activity against Intracellular Pathogens

Tan, B. H., Meinken, C., Bastian, M., Bruns, H., Legaspi, A., Ochoa, M. T., Krutzik, S. R., Bloom, B. R., Ganz, T., Modlin, R. L., et al. (2006) · The Journal of Immunology

Tuberculosis Research and EpidemiologyAntimicrobial Peptides and Activities

Cited by 267

Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4

Lin, L., Valore, E. V., Nemeth, E., Goodnough, J. B., Gabayan, V., & Ganz, T. (2007) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 267

Testosterone Suppresses Hepcidin in Men: A Potential Mechanism for Testosterone-Induced Erythrocytosis

Bachman, E., Feng, R., Travison, T., Li, M., Olbina, G., Ostland, V., Ulloor, J., Zhang, A., Basaria, S., Ganz, T., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism

Iron Metabolism and DisordersHormonal and reproductive studies

Cited by 247

Proinflammatory state, hepcidin, and anemia in older persons

Ferrucci, L., Semba, R. D., Guralnik, J. M., Ershler, W. B., Bandinelli, S., Patel, K. V., Sun, K., Woodman, R. C., Andrews, N. C., Cotter, R. J., et al. (2010) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 245