Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project
Open accessAbstract
Iron is tightly connected to oxygen homeostasis and erythropoiesis. Our aim was to better understand how hypoxia regulates iron acquisition for erythropoiesis in humans, a topic relevant to common hypoxia-related disorders. Forty-seven healthy volunteers participated in the HIGHCARE project. Blood samples were collected at sea level and after acute and chronic exposure to high altitude (3400-5400 m above sea level). We investigated the modifications in hematocrit, serum iron indices, erythropoietin, markers of erythropoietic activity, interleukin-6, and serum hepcidin. Hepcidin decreased within 40 hours after acute hypoxia exposure (P < .05) at 3400 m, reaching the lowest level at 5400 m (80% reduction). Erythropoietin significantly increased (P < .001) within 16 hours after hypoxia exposure followed by a marked erythropoietic response supported by the increased iron supply. Growth differentiation factor-15 progressively increased during the study period. Serum ferritin showed a very rapid decrease, suggesting the existence of hypoxia-dependent mechanism(s) regulating storage iron mobilization. The strong correlation between serum ferritin and hepcidin at each point during the study indicates that iron itself or the kinetics of iron use in response to hypoxia may signal hepcidin down-regulation. The combined and significant changes in other variables probably contribute to the suppression of hepcidin in this setting.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Serum iron and ferritin levels are decreased in Chuvash patients and in individuals sojourning at high altitude for 10-12 days.
“Serum iron and ferritin levels are decreased in Chuvash patients and in individuals sojourning at high altitude for 10–12 days.”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [211]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Fitzmaurice, G. M., Laird, N. M., & Ware, J. H. (2011) · Wiley Series in Probability and Statistics · doi:10.1002/9781119513469 · Cited by 4,639 · see citing works
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · see citing works
Self-citation(2004) · Choice Reviews Online · doi:10.5860/choice.42-2265 · Cited by 1,385 · see citing works
HIF-1 and mechanisms of hypoxia sensing
Semenza, G. L. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00194-0 · Cited by 1,267 · see citing works
Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214 · see citing works
Semenza, G. L., Nejfelt, M. K., Chi, S. M., & Antonarakis, S. E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5680 · Cited by 990 · see citing works
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
Tanno, T., Bhanu, N. V., Oneal, P. A., Goh, S.-H., Staker, P., Lee, Y. T., Moroney, J. W., Reed, C. H., Luban, N. L., Wang, R.-H., et al. (2007) · Nature Medicine · doi:10.1038/nm1629 · Cited by 854 · see citing works
Self-citationImmunoassay for human serum hepcidin
Ganz, T., Olbina, G., Girelli, D., Nemeth, E., & Westerman, M. (2008) · Blood · doi:10.1182/blood-2008-02-139915 · Cited by 688 · see citing works
Self-citationRegulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
Peyssonnaux, C., Zinkernagel, A. S., Schuepbach, R. A., Rankin, E., Vaulont, S., Haase, V. H., Nizet, V., & Johnson, R. S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31370 · Cited by 639 · see citing works
Suppression of hepcidin during anemia requires erythropoietic activity
Pak, M., Lopez, M. A., Gabayan, V., Ganz, T., & Rivera, S. (2006) · Blood · doi:10.1182/blood-2006-06-028787 · Cited by 472 · see citing works
Self-citationHartmann, G., Tschöp, M. H., Fischer, R., Bidlingmaier, C., Riepl, R. L., Tschöp, K., Hautmann, H., Endres, S., & Toepfer, M. (2000) · Cytokine · doi:10.1006/cyto.1999.0533 · Cited by 470 · see citing works
Regulators of iron balance in humans [see comments]
Finch, C. (1994) · Blood · doi:10.1182/blood.v84.6.1697.1697 · Cited by 455 · see citing works
Tanno, T., Porayette, P., Sripichai, O., Noh, S.-J., Byrnes, C., Bhupatiraju, A., Lee, Y. T., Goodnough, J. B., Harandi, O., Ganz, T., et al. (2009) · Blood · doi:10.1182/blood-2008-12-195503 · Cited by 352 · see citing works
Self-citationRate of erythropoietin formation in humans in response to acute hypobaric hypoxia
Eckardt, K., Boutellier, U., Kurtz, A., Schopen, M., Koller, E. A., & Bauer, C. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.66.4.1785 · Cited by 309 · see citing works
Lin, L., Valore, E. V., Nemeth, E., Goodnough, J. B., Gabayan, V., & Ganz, T. (2007) · Blood · doi:10.1182/blood-2007-04-087593 · Cited by 267 · see citing works
Self-citationThe human side of hypoxia‐inducible factor
Smith, T. G., Robbins, P. A., & Ratcliffe, P. J. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07029.x · Cited by 264 · see citing works
Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis
Vokurka, M., Krijt, J., Šulc, K., & Nečas, E. (2006) · Physiological Research · doi:10.33549/physiolres.930841 · Cited by 263 · see citing works
Pinto, J. P., Ribeiro, S., Pontes, H., Thowfeequ, S., Tosh, D., Carvalho, F. D., & Porto, G. (2008) · Blood · doi:10.1182/blood-2007-08-106195 · Cited by 239 · see citing works
Role of the hypoxia inducible factors HIF in iron metabolism
Peyssonnaux, C., Nizet, V., & Johnson, R. S. (2008) · Cell Cycle · doi:10.4161/cc.7.1.5145 · Cited by 217 · see citing works
Ashby, D. R., Gale, D. P., Busbridge, M., Murphy, K. G., Duncan, N. D., Cairns, T. D., Taube, D. H., Bloom, S. R., Tam, F. W. K., Chapman, R., et al. (2010) · Haematologica · doi:10.3324/haematol.2009.013136 · Cited by 191 · see citing works
Iron regulation and erythropoiesis
Nemeth, E. (2008) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3282f73335 · Cited by 175 · see citing works
Control of marrow production by the level of iron supply
Hillman, R. S., & Henderson, P. A. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106002 · Cited by 170 · see citing works
The effect of erythroid hyperplasia on iron balance
Pootrakul, P., Kitcharoen, K., Yansukon, P., Wasi, P., Fucharoen, S., Charoenlarp, P., Brittenham, G. M., Pippard, M. J., & Finch, C. A. (1988) · Blood · doi:10.1182/blood.v71.4.1124.1124 · Cited by 167 · see citing works
Robach, P., Cairo, G., Gelfi, C., Bernuzzi, F., Pilegaard, H., Viganò, A., Santambrogio, P., Cerretelli, P., Calbet, J. A. L., Moutereau, S., et al. (2007) · Blood · doi:10.1182/blood-2006-08-040006 · Cited by 141 · see citing works
Tamary, H., Shalev, H., Perez-Avraham, G., Zoldan, M., Levi, I., Swinkels, D. W., Tanno, T., & Miller, J. L. (2008) · Blood · doi:10.1182/blood-2008-06-165738 · Cited by 135 · see citing works
ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPα and STAT-3
Choi, S.-O., Cho, Y.-S., Kim, H.-L., & Park, J.-W. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.02.137 · Cited by 122 · see citing works
Hepcidin modulation in human diseases: From research to clinic
Piperno, A., Mariani, R., Trombini, P., & Girelli, D. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.538 · Cited by 115 · see citing works
Self-citationControl of erythropoiesis in humans during prolonged exposure to the altitude of 6,542 m
Richalet, J., Souberbielle, J., Antezana, A. M., Déchaux, M., Trong, J. L. L., Bienvenu, A., Daniel, F., Blanchot, C., & Zittoun, J. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.3.r756 · Cited by 106 · see citing works
Ramirez, J., Schaad, O., Durual, S., Cossali, D., Docquier, M., Beris, P., Descombes, P., & Matthes, T. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07441.x · Cited by 96 · see citing works
Iron-Sensing Proteins that Regulate Hepcidin and Enteric Iron Absorption
Knutson, M. D. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104801 · Cited by 96 · see citing works
Regulation of growth differentiation factor 15 expression by intracellular iron
Lakhal, S., Talbot, N. P., Crosby, A., Stoepker, C., Townsend, A. R. M., Robbins, P. A., Pugh, C. W., Ratcliffe, P. J., & Mole, D. R. (2009) · Blood · doi:10.1182/blood-2008-07-170431 · Cited by 95 · see citing works
Volke, M., Gale, D. P., Maegdefrau, U., Schley, G., Klanke, B., Bosserhoff, A.-K., Maxwell, P. H., Eckardt, K.-U., & Warnecke, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007875 · Cited by 93 · see citing works
Robach, P., Recalcati, S., Girelli, D., Gelfi, C., Aachmann‐Andersen, N. J., Thomsen, J. J., Norgaard, A. M., Alberghini, A., Campostrini, N., Castagna, A., et al. (2009) · Blood · doi:10.1182/blood-2008-09-178095 · Cited by 86 · see citing works
Lasocki, S., Millot, S., Andrieu, V., Lettéron, P., Pilard, N., Muzeau, F., Thibaudeau, O., Montravers, P., & Beaumont, C. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31818103b9 · Cited by 83 · see citing works
2-Oxoglutarate-dependent oxygenases control hepcidin gene expression
Braliou, G. G., Falzacappa, M. V. V., Chachami, G., Casanovas, G., Muckenthaler, M. U., & Simos, G. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2007.12.021 · Cited by 67 · see citing works
Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency
Finkenstedt, A., Bianchi, P., Theurl, I., Vogel, W., Witcher, D. R., Wroblewski, V. J., Murphy, A. T., Zanella, A., & Zoller, H. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07535.x · Cited by 51 · see citing works
Blood Volume Changes during Three-Week Residence at High Altitude
Myhre, L. G., Dill, D. B., Hall, F. G., & Brown, D. K. (1970) · Clinical Chemistry · doi:10.1093/clinchem/16.1.7 · Cited by 26 · see citing works
Diseased red blood cells topple iron balance
Chou, S. T., & Weiss, M. J. (2007) · Nature Medicine · doi:10.1038/nm0907-1020 · Cited by 5 · see citing works
Flagged first, then by citations
2 of the 40 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Regulation of erythropoiesis by hypoxia-inducible factors
Haase, V. H. (2013) · Blood Reviews · doi:10.1016/j.blre.2012.12.003 · Cited by 787 · see citing works
Hepcidin in the diagnosis of iron disorders
Girelli, D., Nemeth, E., & Swinkels, D. W. (2016) · Blood · doi:10.1182/blood-2015-12-639112 · Cited by 417 · see citing works
Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives
Jankowska, E. A., von Haehling, S., Anker, S. D., Macdougall, I. C., & Ponikowski, P. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs224 · Cited by 399 · see citing works
Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis
Liu, Q., Davidoff, O., Niss, K., & Haase, V. H. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63924 · Cited by 328 · see citing works
Iron considerations for the athlete: a narrative review
Sim, M., Garvican-Lewis, L. A., Cox, G. R., Govus, A., McKay, A. K. A., Stellingwerff, T., & Peeling, P. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-019-04157-y · Cited by 274 · see citing works
Waldvogel‐Abramowski, S., Waeber, G., Gassner, C., Buser, A. S., Frey, B. M., Favrat, B., & Tissot, J. (2014) · Transfusion Medicine and Hemotherapy · doi:10.1159/000362888 · Cited by 263 · see citing works
GDF15: a hormone conveying somatic distress to the brain
Lockhart, S. M., Saudek, V., & O’Rahilly, S. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa007 · Cited by 256 · see citing works
Besarab, A., Chernyavskaya, E. A., Motylev, I., Shutov, E. V., Kumbar, L. M., Gurevich, K., Chan, D. T. M., Leong, R., Poole, L., Zhong, M., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015030241 · Cited by 250 · see citing works
Holdstock, L., Meadowcroft, A. M., Maier, R., Johnson, B. M., Jones, D., Rastogi, A., Zeig, S., Lepore, J. J., & Cobitz, A. R. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014111139 · Cited by 198 · see citing works
Out of Balance—Systemic Iron Homeostasis in Iron-Related Disorders
Steinbicker, A. U., & Muckenthaler, M. U. (2013) · Nutrients · doi:10.3390/nu5083034 · Cited by 196 · see citing works
Impact of High Altitude on Cardiovascular Health: Current Perspectives
Mallet, R. T., Burtscher, J., Richalet, J., Millet, G. P., & Burtscher, M. (2021) · Vascular Health and Risk Management · doi:10.2147/vhrm.s294121 · Cited by 200 · see citing works
Hypoxia-inducible factors link iron homeostasis and erythropoiesis
Shah, Y. M., & Xie, L. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.12.031 · Cited by 187 · see citing works
Role of hepcidin in the pathophysiology and diagnosis of anemia
D’Angelo, G. (2013) · Blood Research · doi:10.5045/br.2013.48.1.10 · Cited by 187 · see citing works
Physiology and pathophysiology of iron in hemoglobin-associated diseases
Coates, T. D. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.039 · Cited by 181 · see citing works
Iron Status and the Acute Post-Exercise Hepcidin Response in Athletes
Peeling, P., Sim, M., Badenhorst, C. E., DAWSON, B. T., Govus, A. D., Abbiss, C. R., Swinkels, D. W., & Trinder, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093002 · Cited by 171 · see citing works
Marques, O., Weiß, G., & Muckenthaler, M. U. (2022) · Blood · doi:10.1182/blood.2021013472 · Cited by 171 · see citing works
Moccia, F. D., Gerbino, A., Lionetti, V., Miragoli, M., Munaron, L., Pagliaro, P., Pasqua, T., Penna, C. R. R., Rocca, C., Samaja, M., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00198-w · Cited by 160 · see citing works
Mastrogiannaki, M., Matak, P., Mathieu, J. R. R., Delga, S., Mayeux, P., Vaulont, S., & Peyssonnaux, C. (2011) · Haematologica · doi:10.3324/haematol.2011.056119 · Cited by 161 · see citing works
Hepcidin-ferroportin axis in health and disease
Ginzburg, Y. Z. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.01.002 · Cited by 165 · see citing works
Pasricha, S., Frazer, D. M., Bowden, D. K., & Anderson, G. J. (2013) · Blood · doi:10.1182/blood-2012-12-471441 · Cited by 154 · see citing works
Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB
Sonnweber, T., Nachbaur, D., Schroll, A., Nairz, M., Seifert, M., Demetz, E., Haschka, D., Mitterstiller, A.-M., Kleinsasser, A., Burtscher, M., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305317 · Cited by 145 · see citing works
Low hepcidin accounts for the proinflammatory status associated with iron deficiency
Pagani, A., Nai, A., Corna, G., Bosurgi, L., Rovere-Querini, P., Camaschella, C., & Silvestri, L. (2011) · Blood · doi:10.1182/blood-2011-02-337212 · Cited by 138 · see citing works
Parati, G., Bilo, G., Faini, A., Bilo, B., Revera, M., Giuliano, A., Lombardi, C., Caldara, G., Gregorini, F., Styczkiewicz, K., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu275 · Cited by 131 · see citing works
Self-citationAdaptation of iron requirement to hypoxic conditions at high altitude
Gassmann, M., & Muckenthaler, M. U. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00248.2015 · Cited by 123 · see citing works
Dysregulated iron metabolism in polycythemia vera: etiology and consequences
Ginzburg, Y. Z., Feola, M., Zimran, E., Várkonyi, J., Ganz, T., & Hoffman, R. (2018) · Leukemia · doi:10.1038/s41375-018-0207-9 · Cited by 118 · see citing works
Self-citationThe gut in iron homeostasis: role of HIF-2 under normal and pathological conditions
Mastrogiannaki, M., Matak, P., & Peyssonnaux, C. (2013) · Blood · doi:10.1182/blood-2012-11-427765 · Cited by 116 · see citing works
The iron-regulatory hormone hepcidin: A possible therapeutic target?
Rochette, L., Gudjoncik, A., Guénancia, C., Zeller, M., Cottin, Y., & Vergely, C. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.09.004 · Cited by 99 · see citing works
Traglia, M., Girelli, D., Biino, G., Campostrini, N., Corbella, M., Sala, C., Masciullo, C., Viganò, F., Buetti, I., Pistis, G., et al. (2011) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2011-100061 · Cited by 97 · see citing works
Regulation of hepcidin expression at high altitude
Talbot, N. P., Lakhal, S., Smith, T. G., Privat, C., Nickol, A. H., Rivera-Ch, M., León-Velarde, F., Dorrington, K. L., Mole, D. R., & Robbins, P. A. (2012) · Blood · doi:10.1182/blood-2011-03-341776 · Cited by 93 · see citing works
Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers
Goetze, O., Schmitt, J., Spliethoff, K., Theurl, I., Weiß, G., Swinkels, D. W., Tjalsma, H., Maggiorini, M., Krayenbühl, P. A., Rau, M., et al. (2013) · Hepatology · doi:10.1002/hep.26581 · Cited by 93 · see citing works
Govus, A. D., Garvican-Lewis, L. A., Abbiss, C. R., Peeling, P., & Gore, C. J. (2015) · PLOS ONE · doi:10.1371/journal.pone.0135120 · Cited by 91 · see citing works
Systemic Hypertension at High Altitude
Narvaez-Guerra, O. D., Herrera-Enriquez, K. B., Medina‐Lezama, J., & Chirinos, J. A. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11140 · Cited by 86 · see citing works
Regulation of Hepcidin by Erythropoiesis: The Story So Far
Pasricha, S., McHugh, K., & Drakesmith, H. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050731 · Cited by 81 · see citing works
Holdstock, L., Čižman, B., Meadowcroft, A. M., Biswas, N., Johnson, B. M., Jones, D., Kim, S. G., Zeig, S., Lepore, J. J., & Cobitz, A. R. (2018) · Clinical Kidney Journal · doi:10.1093/ckj/sfy013 · Cited by 79 · see citing works
Hypoxia and low temperature upregulate transferrin to induce hypercoagulability at high altitude
Li, M., Tang, X., Liao, Z., Shen, C., Cheng, R., Fang, M., Gan, W., Li, Y., Tang, S., Xie, L., et al. (2022) · Blood · doi:10.1182/blood.2022016410 · Cited by 77 · see citing works
Hepcidin: Homeostasis and Diseases Related to Iron Metabolism
Reichert, C. O., da Cunha, J., Levy, D., Maselli, L. M. F., Bydlowski, S. P., & Spada, C. (2017) · Acta Haematologica · doi:10.1159/000471838 · Cited by 74 · see citing works
Regulation of systemic iron homeostasis
Finberg, K. E. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e32835f5a47 · Cited by 72 · see citing works
Effect of Intravenous Iron on Aerobic Capacity and Iron Metabolism in Elite Athletes
Burden, R. J., Pollock, N., Whyte, G. P., Richards, T., MOORE, B., Busbridge, M., Srai, S. K., Otto, J. M., & Pedlar, C. R. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000568 · Cited by 74 · see citing works
What can we learn from ineffective erythropoiesis in thalassemia?
Oikonomidou, P. R., & Rivella, S. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.10.001 · Cited by 64 · see citing works
Effects of an acute exercise bout on serum hepcidin levels
Domínguez, R., Sánchez-Oliver, A., Mata-Ordoñez, F., Feria-Madueño, A., Grimaldi-Puyana, M., López-Samanes, Á., & Pérez-López, A. (2018) · Nutrients · doi:10.3390/nu10020209 · Cited by 64 · see citing works
“Nevertheless, the hypoxia-inducible factor may be stimulated by different signaling mechanisms [130], and potentially have an EPO-independent effect on hepcidin production [126,131].”
BackgroundFerrari, A. D., Miranda, J. J., Gilman, R. H., Dávila‐Román, V. G., Lèon‐Velarde, F., Rivera, M. C., Huicho, L., Bernabé‐Ortiz, A., Wise, R. A., & Checkley, W. (2014) · CHEST Journal · doi:10.1378/chest.14-0298 · Cited by 63 · see citing works
Vela, D. (2018) · Molecular Medicine · doi:10.1186/s10020-018-0008-7 · Cited by 63 · see citing works
The evolving science of detection of ‘blood doping’
Lundby, C., Robach, P., & Saltin, B. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01822.x · Cited by 56 · see citing works
Aging, High Altitude, and Blood Pressure: A Complex Relationship
Parati, G., Ochoa, J. E., Torlasco, C., Salvi, P., Lombardi, C., & Bilo, G. (2015) · High Altitude Medicine & Biology · doi:10.1089/ham.2015.0010 · Cited by 53 · see citing works
Self-citationHepcidin demonstrates a biphasic association with anemia in acute Plasmodium falciparum malaria
Casals-Pascual, C., Huang, H., Lakhal-Littleton, S., Thezenas, M. L., Kai, O., Newton, C. R. J. C., & Roberts, D. J. (2012) · Haematologica · doi:10.3324/haematol.2012.065854 · Cited by 47 · see citing works
Haase‐Fielitz, A., Mertens, P. R., Plaß, M., Kuppe, H., Hetzer, R., Westerman, M. E., Ostland, V. E., Prowle, J. R., Bellomo, R., & Haase, M. (2011) · Critical Care · doi:10.1186/cc10339 · Cited by 46 · see citing works
Self-citationIron metabolism in high-altitude residents
Muckenthaler, M. U., Mairbäurl, H., & Gassmann, M. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00019.2020 · Cited by 44 · see citing works
Intravenous Iron Does Not Augment the Hemoglobin Mass Response to Simulated Hypoxia
Garvican‐Lewis, L. A., Vuong, V. L., Govus, A. D., Peeling, P., JUNG, G., Nemeth, E., Hughes, D. C., Lovell, G., Eichner, D., & Gore, C. J. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001608 · Cited by 46 · see citing works
Zakharova, E. T., Kostevich, V. A., Av, S., & Vasilyev, V. B. (2012) · BioMetals · doi:10.1007/s10534-012-9586-y · Cited by 43 · see citing works
The Hypoxia-Inducible Factor–C/EBPα Axis Controls Ethanol-Mediated Hepcidin Repression
Anderson, E. R., Taylor, M. J., Xue, X., Martin, A. S., Moons, D. S., Omary, M. B., & Shah, Y. M. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00723-12 · Cited by 42 · see citing works
Unraveling Mechanisms Regulating Systemic Iron Homeostasis
Finberg, K. E. (2011) · Hematology · doi:10.1182/asheducation-2011.1.532 · Cited by 39 · see citing works
Altered erythropoiesis and iron metabolism in carriers of thalassemia
Guimarães, J. D. S., Cominal, J. G., Silva‐Pinto, A. C., Olbina, G., Ginzburg, Y. Z., Nandi, V., Westerman, M. E., Rivella, S., & de Souza, A. M. (2014) · European Journal Of Haematology · doi:10.1111/ejh.12464 · Cited by 38 · see citing works
Self-citationHepcidin Expression in Iron Overload Diseases Is Variably Modulated by Circulating Factors
Ravasi, G., Pelucchi, S., Trombini, P., Mariani, R., Tomosugi, N., Modignani, G. L., Pozzi, M., Nemeth, E., Ganz, T., Hayashi, H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036425 · Cited by 34 · see citing works
Self-citationInfluence of post-exercise hypoxic exposure on hepcidin response in athletes
Badenhorst, C. E., DAWSON, B. T., Goodman, C., Sim, M., Cox, G. R., Gore, C. J., Tjalsma, H., Swinkels, D. W., & Peeling, P. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2829-6 · Cited by 35 · see citing works
Expedition 5300: limits of human adaptations in the highest city in the world
Champigneulle, B., Brugniaux, J. V., Stauffer, É., Doutreleau, S., Furian, M., Perger, E., Pina, A., Baillieul, S., Deschamps, B., Hancco, I., et al. (2023) · The Journal of Physiology · doi:10.1113/jp284550 · Cited by 33 · see citing works
Investigational therapies for renal disease-induced anemia
Schmid, H., & JELKMANN, W. E. B. (2016) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2016.1182981 · Cited by 33 · see citing works
Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice
Díaz, V., Gammella, E., Recalcati, S., Santambrogio, P., Naldi, A. M., Vogel, J., Gassmann, M., & Cairo, G. (2013) · Hepatology · doi:10.1002/hep.26550 · Cited by 33 · see citing works
Duca, L., Ottolenghi, S., Coppola, S., Rinaldo, R. F., Dei, M., Rubino, F. M., Paroni, R. C., Samaja, M., Chiumello, D., & Motta, I. (2021) · Antioxidants · doi:10.3390/antiox10091460 · Cited by 33 · see citing works
Interleukin-10 Regulates Hepcidin in Plasmodium falciparum Malaria
Huang, H., Lamikanra, A., Alkaitis, M. S., Thézénas, M. L., Ramaprasad, A., Moussa, E., Roberts, D. J., & Casals‐Pascual, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088408 · Cited by 32 · see citing works
Plasma hepcidin of Ethiopian highlanders with steady-state hypoxia
Lundgrin, E. L., Janocha, A. J., Koch, C. D., Gebremedhin, A., Rienzo, A. D., Alkorta‐Aranburu, G., Brittenham, G. M., ERZURUM, S. C., & Beall, C. M. (2013) · Blood · doi:10.1182/blood-2013-03-491068 · Cited by 30 · see citing works
Govus, A. D., Abbiss, C. R., Garvican‐Lewis, L. A., Swinkels, D. W., Laarakkers, C. M., Gore, C. J., & Peeling, P. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2938-2 · Cited by 30 · see citing works
Revera, M., Salvi, P., Faini, A., Giuliano, A., Gregorini, F., Bilo, G., Lombardi, C., Mancia, G., Agostoni, P., & Parati, G. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09197 · Cited by 29 · see citing works
Self-citationGestational Age-Specific Reference Ranges of Hepcidin in Cord Blood
Springer, L., Herbst, J., Engel, C., Peter, A., Abele, H., Poets, C. F., Westerman, M. E., & Franz, A. R. (2014) · Neonatology · doi:10.1159/000360072 · Cited by 28 · see citing works
Self-citationTandara, L., Grubišić, T. Ž., Gudelj, I., Jurišić, Z., Tandara, M., Gugo, K., Mladinov, S., & Salamunić, I. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.07.010 · Cited by 30 · see citing works
The Functional Versatility of Transferrin Receptor 2 and Its Therapeutic Value
Roetto, A., Mezzanotte, M., & Pellegrino, R. M. (2018) · Pharmaceuticals · doi:10.3390/ph11040115 · Cited by 27 · see citing works
Samaja, M., & Ottolenghi, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043670 · Cited by 28 · see citing works
Circulating factors are involved in hypoxia-induced hepcidin suppression
Ravasi, G., Pelucchi, S., Greni, F., Mariani, R., Giuliano, A., Parati, G., Silvestri, L., & Piperno, A. (2014) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2014.06.006 · Cited by 25 · see citing works
Self-citationLiu, Y., Huang, H., Zhou, S.-M., Tian, H.-J., & Li, P. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00548 · Cited by 25 · see citing works
Robach, P., Recalcati, S., Girelli, D., Campostrini, N., Kempf, T., Wollert, K. C., Corbella, M., Santambrogio, P., Perbellini, L., Brasse‐Lagnel, C., et al. (2013) · European Journal Of Haematology · doi:10.1111/ejh.12122 · Cited by 25 · see citing works
Effect of Iron Deficiency on a Murine Model of Smoke-induced Emphysema
Sato, K., Inoue, S., Igarashi, A., Tokairin, Y., Yamauchi, K., Kimura, T., Nishiwaki, M., Nemoto, T., Nakano, H., Sato, M., et al. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0239oc · Cited by 25 · see citing works
Andersen, A. B., Bonne, T. C., Bejder, J., Jung, G., Ganz, T., Nemeth, E., Olsen, N. V., Huertas, J. R., & Nordsborg, N. B. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00070.2021 · Cited by 24 · see citing works
Self-citationIron Mining for Erythropoiesis
Correnti, M., Gammella, E., Cairo, G., & Recalcati, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105341 · Cited by 27 · see citing works
Reduced cancer mortality at high altitude: The role of glucose, lipids, iron and physical activity
Thiersch, M., Swenson, E. R., Haider, T., & Gassmann, M. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.03.048 · Cited by 23 · see citing works
Iron and Sphingolipids as Common Players of (Mal)Adaptation to Hypoxia in Pulmonary Diseases
Ottolenghi, S., Zulueta, A., & Caretti, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010307 · Cited by 24 · see citing works
High-Altitude Hypoxia Decreases Plasma Erythropoietin Soluble Receptor Concentration in Lowlanders
Vizcardo‐Galindo, G. A., Lèon‐Velarde, F., & Villafuerte, F. C. (2020) · High Altitude Medicine & Biology · doi:10.1089/ham.2019.0118 · Cited by 24 · see citing works
Impact of Hypoxia over Human Viral Infections and Key Cellular Processes
Reyes, A., Duarte, L. F., Farías, M. A., Tognarelli, E. I., Kalergis, A. M., Bueno, S. M., & González, P. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157954 · Cited by 23 · see citing works
Evaluation of serum hepcidin and iron levels in patients with PCOS: a case-control study
Rashidi, B. H., Shams, S., Shariat, M., Jaliseh, H. K., Mohebi, M., & Haghollahi, F. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0632-z · Cited by 23 · see citing works
Hepcidin regulation in a mouse model of acute hypoxia
Ravasi, G., Pelucchi, S., Comani, G. B., Greni, F., Mariani, R., Pelloni, I., Bombelli, S., Perego, R., Barisani, D., & Piperno, A. (2018) · European Journal Of Haematology · doi:10.1111/ejh.13062 · Cited by 22 · see citing works
Self-citationWillie, C. K., Patrician, A., Hoiland, R. L., Williams, A. M., Gasho, C., Subedi, P., Anholm, J. D., Drane, A. L., Tymko, M. M., Nowak‐Flück, D., et al. (2021) · The Journal of Physiology · doi:10.1113/jp281114 · Cited by 22 · see citing works
Hepcidin in chronic kidney disease anemia
Santos‐Silva, A., Ribeiro, S., Reis, F., & Belo, L. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.01.012 · Cited by 23 · see citing works
Meroño, O., Cladellas, M., Ribas, N., Poveda, P. M., Recasens, L., Bazán, V., García‐García, C., Ivern, C., Enjuanes, C., Orient, S., et al. (2016) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2016.10.004 · Cited by 21 · see citing works
Prolonged exposure to welding fumes as a novel cause of systemic iron overload
Mariani, R., Pelucchi, S., Paolini, V., Belingheri, M., Gennaro, F. D., Faverio, P., Riva, M. A., Pesci, A., & Piperno, A. (2021) · Liver International · doi:10.1111/liv.14874 · Cited by 19 · see citing works
Self-citationMalhotra, H., Kumar, M., Chauhan, A. S., Dhiman, A., Chaudhary, S., Patidar, A., Jaiswal, P., Sharma, K., Sheokand, N., Raje, C. I., et al. (2019) · Cellular Physiology and Biochemistry · doi:10.33594/000000037 · Cited by 18 · see citing works
Goralska, M., Fleisher, L. N., & McGahan, M. C. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.05.010 · Cited by 17 · see citing works
Increased hepcidin levels in high-altitude pulmonary edema
Altamura, S., Bärtsch, P., Dehnert, C., Maggiorini, M., Weiß, G., Theurl, I., Muckenthaler, M. U., & Mairbäurl, H. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00940.2014 · Cited by 17 · see citing works
Hepcidin and its potential clinical utility
Miseta, A., Nagy, J., Nagy, T., Poór, V. S., Fekete, Z., & Sipos, K. (2015) · Cell Biology International · doi:10.1002/cbin.10505 · Cited by 16 · see citing works
Mutual Cross Talk Between Iron Homeostasis and Erythropoiesis
Rybińska, I., & Cairo, G. (2017) · Vitamins and hormones · doi:10.1016/bs.vh.2017.01.001 · Cited by 16 · see citing works
Suppression of plasma hepcidin by venesection during steady-state hypoxia
Talbot, N. P., Smith, T. G., Lakhal‐Littleton, S., Gülsever, C. İ., Rivera, M. C., Dorrington, K. L., Mole, D. R., & Robbins, P. A. (2016) · Blood · doi:10.1182/blood-2015-05-647404 · Cited by 15 · see citing works
Janus, or the Inevitable Battle Between Too Much and Too Little Oxygen
Mancardi, D., Ottolenghi, S., Attanasio, U., Tocchetti, C. G., Paroni, R. C., Pagliaro, P., & Samaja, M. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0232 · Cited by 15 · see citing works
DNA methylation in adaptation to high-altitude environments and pathogenesis of related diseases
Zhang, X., Yang, Y., & Shi, Q. (2025) · Human Genomics · doi:10.1186/s40246-025-00794-x · Cited by 14 · see citing works
Activation of Intestinal HIF2α Ameliorates Iron‐Refractory Anemia
Yu, Y., Su, Y., Yang, S., Liu, Y., Lin, Z., Das, N. K., Wu, Q., Zhou, J., Sun, S., Li, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202307022 · Cited by 13 · see citing works
Maira, D., Duca, L., Busti, F., Consonni, D., Salvatici, M., Vianello, A., Milani, A., Guzzardella, A., Pierro, E. D., Aliberti, S., et al. (2022) · American Journal of Hematology · doi:10.1002/ajh.26679 · Cited by 13 · see citing works
Abosalif, K. O. A., Abdalla, A. E., Junaid, K., Eltayeb, L. B., & Ejaz, H. (2023) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2023.103805 · Cited by 14 · see citing works
Modulation of urinary peptidome in humans exposed to high altitude hypoxia
Mainini, V., Gianazza, E., Chinello, C., Bilo, G., Revera, M., Giuliano, A., Caldara, G., Lombardi, C., Piperno, A., Magni, F., et al. (2011) · Molecular BioSystems · doi:10.1039/c1mb05377a · Cited by 14 · see citing works
Self-citationChen, Y., Jiang, C., Luo, Y., Liu, F., & Gao, Y. (2015) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2015.11.005 · Cited by 14 · see citing works
Hepcidin and its multiple partners: Complex regulation of iron metabolism in health and disease
Ginzburg, Y. Z. (2023) · Vitamins and hormones · doi:10.1016/bs.vh.2023.03.001 · Cited by 15 · see citing works
Targeting HIF-1α in sickle cell disease and cancer: unraveling therapeutic opportunities and risks
Ubaid, S., Kashif, M., Laiq, Y., Nayak, A., Kumar, V., & Singh, V. K. (2024) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2024.2367640 · Cited by 11 · see citing works
Gatterer, H., Roche, J., Turner, R., Vinetti, G., Roveri, G., Schlittler, M., Kob, M., Walzl, A., Cappello, T. D., Debevec, T., et al. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00369.2022 · Cited by 11 · see citing works
Paul, S., Bhargava, K., & Ahmad, Y. (2017) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201600160 · Cited by 11 · see citing works
Tallec-Estève, N. L., Rousseau, C., Desrues, B., Loréal, O., & Thibault, R. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.06.007 · Cited by 10 · see citing works
- Authors
- Piperno, A., Galimberti, S., Mariani, R., Pelucchi, S., Ravasi, G., Lombardi, C., Bilo, G., Revera, M., Giuliano, A., Faini, A., Mainini, V., Westerman, M., Ganz, T., Valsecchi, M. G., Mancia, G., Parati, G., & for the HIGHCARE investigators
- Affiliations
- Azienda Ospedaliera San Gerardo (IT)
- University of Milano-Bicocca (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Intrinsic LifeSciences (United States) (US)
- University of California, Los Angeles (US)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-03-10
- Volume
- 117
- Issue
- 10
- Pages
- 2953-2959
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2002636442
- Cited by
- 151
- References
- 40
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 10 · 2020: 9 · 2019: 6 · 2018: 12 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 21 · 2013: 14 · 2012: 7
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Funders
- Fondazione Cariplo (2009-2483)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › High Altitude and Hypoxia
- Keywords
- hepcidin, hypoxia, erythropoiesis, high altitude, iron homeostasis, erythropoietin, serum ferritin, growth differentiation factor 15, interleukin-6, iron mobilization, acute hypoxia, chronic hypoxia
- MeSH terms
- Hypoxia, Erythropoiesis, Erythropoietin, Female, Ferritins, Hematocrit, Humans, Iron, Male, Down-Regulation, Antimicrobial Cationic Peptides, Hepcidins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
