Mahley, Robert W.

Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors

Brodbeck, J., McGuire, J., Liu, Z., Meyer-Franke, A., Balestra, M. E., Jeong, D.-E., Pleiss, M., McComas, C., Hess, F., Witter, D., et al. (2011) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 113

A novel electrophoretic variant of human apolipoprotein E. Identification and characterization of apolipoprotein E1

Weisgraber, K. H., Rall, S. C., Innerarity, T. L., Mahley, R. W., Kuusi, T., & Ehnholm, C. (1984) · Journal of Clinical Investigation

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 111

Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3: structure and genetics of an apolipoprotein E3 variant

Rall, S. C., Newhouse, Y. M., Clarke, H. R., Weisgraber, K. H., McCarthy, B. J., Mahley, R. W., & Bersot, T. P. (1989) · Journal of Clinical Investigation

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 103

Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function

Orr, A. L., Kim, C., Jimenez-Morales, D., Newton, B. W., Johnson, J. R., Krogan, N. J., Swaney, D. L., & Mahley, R. W. (2019) · Journal of Alzheimer's Disease

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 103

Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein.

Wilson, C., Mau, T., Weisgraber, K. H., Wardell, M. R., Mahley, R. W., & Agard, D. A. (1994) · Structure

Protein Structure and DynamicsLipoproteins and Cardiovascular Health

Cited by 100

Apolipoprotein E: genetic variants provide insights into its structure and function

Mahley, R. W., Innerarity, T. L., Rail, S. C., Weisgraber, K. H., & Taylor, J. M. (1990) · Current Opinion in Lipidology

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 88

Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons

Brodbeck, J., Balestra, M. E., Saunders, A. M., Roses, A. D., Mahley, R. W., & Huang, Y. (2008) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 86

Lipoproteins of Special Significance in Atherosclerosis: Insights Provided by Studies of Type III Hyperlipoproteinemia

MAHLEY, R. W., INNERARITY, T. L., RALL, S. C., & WEISGRABER, K. H. (1985) · Annals of the New York Academy of Sciences

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 75

Functional unit of the low density lipoprotein receptor of fibroblasts: a 100,000-dalton structure with multiple binding sites.

Innerarity, T. L., Kempner, E. S., Hui, D. Y., & Mahley, R. W. (1981) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 54

Apolipoprotein E: Remarkable Protein Sheds Light on Cardiovascular and Neurological Diseases

Mahley, R. W. (2017) · Clinical Chemistry

Lipoproteins and Cardiovascular HealthAlzheimer's disease research and treatments

Cited by 53

Detrimental Effects of Apolipoprotein E4: Potential Therapeutic Targets in Alzheimers Disease

Mahley, R., Huang, Y., & Weisgraber, K. (2007) · Current Alzheimer Research

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 51

APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation

Marino, C., Perez‐Corredor, P., O'Hare, M., Heuer, A., Chmielewska, N., Gordon, H., Chandrahas, A. S., Gonzalez‐Buendia, L., Delgado‐Tirado, S., Doan, T. H., et al. (2024) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 45

Apolipoprotein E4 targets mitochondria and the mitochondria-associated membrane complex in neuropathology, including Alzheimer's disease

Mahley, R. W. (2023) · Current Opinion in Neurobiology

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 43

Effects of a Frequent Apolipoprotein E Isoform, ApoE4 Freiburg (Leu28→Pro), on Lipoproteins and the Prevalence of Coronary Artery Disease in Whites

Orth, M., Weng, W., Funke, H., Steinmetz, A., Assmann, G., Nauck, M., Dierkes, J., Ambrosch, A., Weisgraber, K. H., Mahley, R. W., et al. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology

Lipoproteins and Cardiovascular HealthLipid metabolism and disorders

Cited by 42

Characterization of apolipoprotein E-containing lipoproteins

Weisgraber, K. H., & Mahley, R. W. (1986) · Methods in Enzymology

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 41

Genetic polymorphism of apolipoprotein E: a variant form of apolipoprotein E2 distinguished by sodium dodecyl sulfate--polyacrylamide gel electrophoresis.

Utermann, G., Weisgraber, K. H., Weber, W., & Mahley, R. W. (1984) · Journal of Lipid Research

Alzheimer's disease research and treatmentsLipoproteins and Cardiovascular Health

Cited by 39

Familial Splenomegaly: Macrophage Hypercatabolism of Lipoproteins Associated with Apolipoprotein E Mutation [Apolipoprotein E (Δ149 Leu)]

Nguyen, T. T., Kruckeberg, K. E., O’Brien, J. F., Ji, Z.-S., Karnes, P. S., Crotty, T. B., Hay, I. D., Mahley, R. W., & O’Brien, T. (2000) · The Journal of Clinical Endocrinology & Metabolism

Lipid metabolism and disordersLysosomal Storage Disorders Research

Cited by 29

Cellular and Molecular Biology of Lipoprotein Metabolism: Characterization of Lipoprotein Receptor-Ligand Interactions

Mahley, R. W., Innerarity, T. L., Weisgraber, K. H., Rall, S. C., Hui, D. Y., Lalazar, A., Boyles, J. K., Taylor, J. M., & Levy-Wilson, B. (1986) · Cold Spring Harbor Symposia on Quantitative Biology

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 22