Varki, Ajit

Biological roles of glycans

Varki, A. (2017) · Glycobiology

Glycosylation and Glycoproteins ResearchCarbohydrate Chemistry and Synthesis

Cited by 2,635

Selectin ligands.

Varki, A. (1994) · Proceedings of the National Academy of Sciences

Cell Adhesion Molecules ResearchGlycosylation and Glycoproteins Research

Cited by 946

Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis

Borsig, L., Wong, R., Feramisco, J., Nadeau, D. R., Varki, N. M., & Varki, A. (2001) · Proceedings of the National Academy of Sciences

Cell Adhesion Molecules ResearchGlycosylation and Glycoproteins Research

Cited by 714

Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid

Tangvoranuntakul, P., Gagneux, P., Diaz, S., Bardor, M., Varki, N., Varki, A., & Muchmore, E. (2003) · Proceedings of the National Academy of Sciences

Glycosylation and Glycoproteins ResearchBlood groups and transfusion

Cited by 625

Evolutionary considerations in relating oligosaccharide diversity to biological function

Gagneux, P., & Varki, A. (1999) · Glycobiology

Glycosylation and Glycoproteins ResearchCarbohydrate Chemistry and Synthesis

Cited by 495

P-selectin deficiency attenuates tumor growth and metastasis

Kim, Y. J., Borsig, L., Varki, N. M., & Varki, A. (1998) · Proceedings of the National Academy of Sciences

Cell Adhesion Molecules ResearchGlycosylation and Glycoproteins Research

Cited by 454

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

Carlin, A. F., Uchiyama, S., Chang, Y.-C., Lewis, A. L., Nizet, V., & Varki, A. (2009) · Blood

Glycosylation and Glycoproteins ResearchNeonatal and Maternal Infections

Cited by 401

Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis

Borsig, L., Wong, R., Hynes, R. O., Varki, N. M., & Varki, A. (2002) · Proceedings of the National Academy of Sciences

Cell Adhesion Molecules ResearchGlycosylation and Glycoproteins Research

Cited by 400

Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins

Ghaderi, D., Taylor, R. E., Padler-Karavani, V., Diaz, S., & Varki, A. (2010) · Nature Biotechnology

Glycosylation and Glycoproteins ResearchViral Infectious Diseases and Gene Expression in Insects

Cited by 372

Fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy are deficient in uridine 5'-diphosphate-N-acetylglucosamine: glycoprotein N-acetylglucosaminylphosphotransferase activity.

Reitman, M. L., Varki, A., & Kornfeld, S. (1981) · Journal of Clinical Investigation

Lysosomal Storage Disorders ResearchGlycogen Storage Diseases and Myoclonus

Cited by 321

Production platforms for biotherapeutic glycoproteins. Occurrence impact, and challenges of non-human sialylation

Ghaderi, D., Zhang, M., Hurtado-Ziola, N., & Varki, A. (2012) · Biotechnology and Genetic Engineering Reviews

Glycosylation and Glycoproteins ResearchViral Infectious Diseases and Gene Expression in Insects

Cited by 320

Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas

Wahrenbrock, M., Borsig, L., Le, D., Varki, N., & Varki, A. (2003) · Journal of Clinical Investigation

Blood Coagulation and Thrombosis MechanismsCell Adhesion Molecules Research

Cited by 317

Heparin’s anti-inflammatory effects require glucosamine 6-o-sulfation and are mediated by blockade of L- and P-selectins

Wang, L., Brown, J. R., Varki, A., & Esko, J. D. (2002) · Journal of Clinical Investigation

Proteoglycans and glycosaminoglycans researchCell Adhesion Molecules Research

Cited by 288

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

Varki, A. (2011) · Glycobiology

Immune Response and InflammationGlycosylation and Glycoproteins Research

Cited by 263

Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin

Byres, E., Paton, A. W., Paton, J. C., Löfling, J. C., Smith, D. F., Wilce, M. C. J., Talbot, U. M., Chong, D. C., Yu, H., Huang, S., et al. (2008) · Nature

Escherichia coli research studiesGlycosylation and Glycoproteins Research

Cited by 233

Loss of Siglec expression on T lymphocytes during human evolution

Nguyen, D. H., Hurtado-Ziola, N., Gagneux, P., & Varki, A. (2006) · Proceedings of the National Academy of Sciences

Glycosylation and Glycoproteins ResearchT-cell and B-cell Immunology

Cited by 204

Calcium-Dependent Heparin-Like Ligands For L-Selectin in Nonlymphoid Endothelial Cells

Norgard-Sumnicht, K. E., Varki, N. M., & Varki, A. (1993) · Science

Cell Adhesion Molecules ResearchProteoglycans and glycosaminoglycans research

Cited by 197

Involvement of a Non-Human Sialic Acid in Human Cancer

Samraj, A. N., Läubli, H., Varki, N., & Varki, A. (2014) · Frontiers in Oncology

Glycosylation and Glycoproteins ResearchBlood groups and transfusion

Cited by 196

Evolution of human-chimpanzee differences in malaria susceptibility: Relationship to human genetic loss of N -glycolylneuraminic acid

Martin, M. J., Rayner, J. C., Gagneux, P., Barnwell, J. W., & Varki, A. (2005) · Proceedings of the National Academy of Sciences

Malaria Research and ControlBlood groups and transfusion

Cited by 193

Evolutionary Forces Shaping the Golgi Glycosylation Machinery: Why Cell Surface Glycans Are Universal to Living Cells

Varki, A. (2011) · Cold Spring Harbor Perspectives in Biology

Glycosylation and Glycoproteins ResearchCellular transport and secretion

Cited by 173

Evolution of genetic and genomic features unique to the human lineage

O'Bleness, M., Searles, V. B., Varki, A., Gagneux, P., & Sikela, J. M. (2012) · Nature Reviews Genetics

Pleistocene-Era Hominins and ArchaeologyGenomic variations and chromosomal abnormalities

Cited by 168

Potential impact of the non‐human sialic acid N‐glycolylneuraminic acid on transplant rejection risk

Padler‐Karavani, V., & Varki, A. (2011) · Xenotransplantation

Xenotransplantation and immune responseGlycosylation and Glycoproteins Research

Cited by 162

Human risk of diseases associated with red meat intake: Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid

Alisson-Silva, F., Kawanishi, K., & Varki, A. (2016) · Molecular Aspects of Medicine

Nutritional Studies and DietMeat and Animal Product Quality

Cited by 156

Developmental abnormalities in transgenic mice expressing a sialic acid-specific 9-O-acetylesterase

Varki, A., Hooshmand, F., Diaz, S., Varki, N. M., & Hedrick, S. M. (1991) · Cell

Glycosylation and Glycoproteins ResearchLysosomal Storage Disorders Research

Cited by 134