Curtis, Christina

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

METABRIC Group, Curtis, C., Shah, S. P., Chin, S.-F., Turashvili, G., Rueda, O. M., Dunning, M. J., Speed, D., Lynch, A. G., Samarajiwa, S., et al. (2012) · Nature

Breast Cancer Treatment StudiesCancer Genomics and Diagnostics

Cited by 6,097

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Shah, S. P., Roth, A., Goya, R., Oloumi, A., Ha, G., Zhao, Y., Turashvili, G., Ding, J., Tse, K., Haffari, G., et al. (2012) · Nature

Cancer Genomics and DiagnosticsBreast Cancer Treatment Studies

Cited by 1,967

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

Sottoriva, A., Spiteri, I., Piccirillo, S. G. M., Touloumis, A., Collins, V. P., Marioni, J. C., Curtis, C., Watts, C., & Tavaré, S. (2013) · Proceedings of the National Academy of Sciences

Cancer Genomics and DiagnosticsGlioma Diagnosis and Treatment

Cited by 1,737

Clonal replacement of tumor-specific T cells following PD-1 blockade

Yost, K. E., Satpathy, A. T., Wells, D. K., Qi, Y., Wang, C., Kageyama, R., McNamara, K. L., Granja, J. M., Sarin, K. Y., Brown, R. A., et al. (2019) · Nature Medicine

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 1,534

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

Liu, M. C., Oxnard, G. R., Klein, E. A., Swanton, C., Seiden, M. V., Liu, M. C., Oxnard, G. R., Klein, E. A., Smith, D., Richards, D., et al. (2020) · Annals of Oncology

Cancer Genomics and DiagnosticsEpigenetics and DNA Methylation

Cited by 1,495

The chromatin accessibility landscape of primary human cancers

Corces, M. R., Granja, J. M., Shams, S., Louie, B. H., Seoane, J. A., Zhou, W., Silva, T. C., Groeneveld, C., Wong, C. K., Cho, S. W., et al. (2018) · Science

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 1,230

Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element

Cho, S. W., Xu, J., Sun, R., Mumbach, M. R., Carter, A. C., Chen, Y. G., Yost, K. E., Kim, J., He, J., Nevins, S. A., et al. (2018) · Cell

Cancer-related molecular mechanisms researchGenomics and Chromatin Dynamics

Cited by 459

Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors Complements Genomic Profiling

Yuan, Y., Failmezger, H., Rueda, O. M., Ali, H. R., Gräf, S., Chin, S.-F., Schwarz, R. F., Curtis, C., Dunning, M. J., Bardwell, H., et al. (2012) · Science Translational Medicine

AI in cancer detectionBreast Cancer Treatment Studies

Cited by 426

CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities

Han, K., Pierce, S. E., Li, A., Spees, K., Anderson, G. R., Seoane, J. A., Lo, Y.-H., Dubreuil, M., Olivas, M., Kamber, R. A., et al. (2020) · Nature

CRISPR and Genetic EngineeringCancer Genomics and Diagnostics

Cited by 311

An expanded universe of cancer targets

Hahn, W. C., Bader, J. S., Braun, T. P., Califano, A., Clemons, P. A., Druker, B. J., Ewald, A. J., Fu, H., Jagu, S., Kemp, C. J., et al. (2021) · Cell

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 213

A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer

Mello, S. S., Valente, L. J., Raj, N., Seoane, J. A., Flowers, B. M., McClendon, J., Bieging-Rolett, K. T., Lee, J., Ivanochko, D., Kozak, M. M., et al. (2017) · Cancer Cell

Cancer-related Molecular PathwaysHippo pathway signaling and YAP/TAZ

Cited by 179

A CRISPR/Cas9-Engineered ARID1A -Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Lo, Y.-H., Kolahi, K. S., Du, Y., Chang, C.-Y., Krokhotin, A., Nair, A., Sobba, W. D., Karlsson, K., Jones, S. J., Longacre, T. A., et al. (2021) · Cancer Discovery

Chromatin Remodeling and CancerCRISPR and Genetic Engineering

Cited by 174

Cell of origin influences pancreatic cancer subtype

Flowers, B. M., Xu, H., Mulligan, A. S., Hanson, K. J., Seoane, J. A., Vogel, H., Curtis, C., Wood, L. D., & Attardi, L. D. (2021) · Cancer Discovery

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 118

Spatial proteomic characterization of HER2-positive breast tumors through neoadjuvant therapy predicts response

McNamara, K. L., Caswell-Jin, J. L., Joshi, R., Ma, Z., Kotler, E., Bean, G. R., Kriner, M., Zhou, Z., Hoang, M., Beechem, J., et al. (2020) · Nature Cancer

HER2/EGFR in Cancer ResearchBreast Cancer Treatment Studies

Cited by 92

Deterministic evolution and stringent selection during preneoplasia

Karlsson, K., Przybilla, M. J., Kotler, E., Khan, A., Xu, H., Karagyozova, K., Sockell, A., Wong, W. H., Liu, K., Mah, A., et al. (2023) · Nature

Cancer Genomics and DiagnosticsEvolution and Genetic Dynamics

Cited by 83

PhyloVelo enhances transcriptomic velocity field mapping using monotonically expressed genes

Wang, K., Hou, L., Wang, X., Zhai, X., Lu, Z., Zi, Z., Zhai, W., He, X., Curtis, C., Zhou, D., et al. (2024) · Nature Biotechnology

Single-cell and spatial transcriptomicsGene Regulatory Network Analysis

Cited by 66