Goedert, Michel

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

Goedert, M., Jakes, R., Crowther, R. A., Cohen, P., Vanmechelen, E., Vandermeeren, M., & Cras, P. (1994) · Biochemical Journal

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 375

Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold

Falcon, B., Zhang, W., Schweighauser, M., Murzin, A. G., Vidal, R., Garringer, H. J., Ghetti, B., Scheres, S. H. W., & Goedert, M. (2018) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 362

Repeat motifs of tau bind to the insides of microtubules in the absence of taxol

Kar, S., Fan, J., Smith, M. J., Goedert, M., & Amos, L. A. (2003) · The EMBO Journal

Microtubule and mitosis dynamicsAlzheimer's disease research and treatments

Cited by 355

Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

Seubert, P., Mawal-Dewan, M., Barbour, R., Jakes, R., Goedert, M., Johnson, G. V. W., Litersky, J. M., Schenk, D., Lieberburg, I., Trojanowski, J. Q., et al. (1995) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 345

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

Schaeffer, V., Lavenir, I., Ozcelik, S., Tolnay, M., Winkler, D. T., & Goedert, M. (2012) · Brain

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 343

Proteasomal degradation of tau protein

David, D. C., Layfield, R., Serpell, L., Narain, Y., Goedert, M., & Spillantini, M. G. (2002) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsUbiquitin and proteasome pathways

Cited by 327

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

Goedert, M., Masuda-Suzukake, M., & Falcon, B. (2017) · Brain

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 323

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A1 Implications for Alzheimer's disease

Goedert, M., Cohen, E. S., Jakes, R., & Cohen, P. (1992) · FEBS Letters

Alzheimer's disease research and treatmentsProtein Tyrosine Phosphatases

Cited by 272

Tau Mutations Cause Frontotemporal Dementias

Goedert, M., Crowther, R. A., & Spillantini, M. G. (1998) · Neuron

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 268

Why has therapy development for dementia failed in the last two decades?

Gauthier, S., Albert, M., Fox, N., Goedert, M., Kivipelto, M., Mestre‐Ferrandiz, J., & Middleton, L. T. (2016) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 238

Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.

Ozcelik, S., Fraser, G., Castets, P., Schaeffer, V., Skachokova, Z., Breu, K., Clavaguera, F., Sinnreich, M., Kappos, L., Goedert, M., et al. (2013) · PLoS ONE

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 226

Propagation of Tau aggregates

Goedert, M., & Spillantini, M. G. (2017) · Molecular Brain

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 213

Glycogen synthase kinase-3β phosphorylates tau protein at multiple sites in intact cells

Sperbera, B. R., Leight, S., Goedert, M., & Lee, V. M.-Y. (1995) · Neuroscience Letters

Alzheimer's disease research and treatmentsProtein Kinase Regulation and GTPase Signaling

Cited by 204

Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation

McEwan, W. A., Falcon, B., Vaysburd, M., Clift, D., Oblak, A. L., Ghetti, B., Goedert, M., & James, L. C. (2017) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 201

Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia

Brelstaff, J., Tolkovsky, A. M., Ghetti, B., Goedert, M., & Spillantini, M. G. (2018) · Cell Reports

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 195

Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy

Lövestam, S., Schweighauser, M., Matsubara, T., Murayama, S., Tomita, T., Ando, T., Hasegawa, K., Yoshida, M., Tarutani, A., Hasegawa, M., et al. (2021) · FEBS Open Bio

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 183

Tau Proteins and Neurofibrillary Degeneration

Goedert, M., Spillantini, M. G., & Crowther, R. A. (1991) · Brain Pathology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 178

Tau protein and neurodegeneration

Goedert, M. (2004) · Seminars in Cell & Developmental Biology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 177

Comparison of the neurofibrillary pathology in Alzheimer’s disease and familial presenile dementia with tangles

Spillantini, M. G., Crowther, R. A., & Goedert, M. (1996) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 160

Invited review: Prion‐like transmission and spreading of tau pathology

Clavaguera, F., Hench, J., Goedert, M., & Tolnay, M. (2015) · Neuropathology and Applied Neurobiology

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 156

Oskar Fischer and the study of dementia

Goedert, M. (2008) · Brain

Neurology and Historical StudiesHistory of Science and Medicine

Cited by 144

A role for FKBP52 in tau protein function

Chambraud, B., Sardin, E., Giustiniani, J., Dounane, O., Schumacher, M., Goedert, M., & Baulieu, E.-E. (2010) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 140

Tau: From research to clinical development

Holtzman, D. M., Carrillo, M. C., Hendrix, J. A., Bain, L. J., Catafau, A. M., Gault, L. M., Goedert, M., Mandelkow, E., Mandelkow, E., Miller, D. S., et al. (2016) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 139

Nerve growth factor mRNA and protein increase in hypothalamus in a mouse model of aggression.

Spillantini, M. G., Aloe, L., Alleva, E., De Simone, R., Goedert, M., & Levi-Montalcini, R. (1989) · Proceedings of the National Academy of Sciences

Nerve injury and regenerationNeuropeptides and Animal Physiology

Cited by 136