Tau protein and neurodegeneration
Abstract
Tau protein is the major component of the intracellular filamentous deposits that define a number of neurodegenerative diseases. They include the largely sporadic Alzheimer's disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick's disease (PiD), argyrophilic grain disease, as well as the inherited frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). The identification of mutations in Tau as the cause of FTDP-17 established that dysfunction or misregulation of tau protein is sufficient to cause neurodegeneration and dementia. At an experimental level, the new understanding is leading to the development of good transgenic animal models of the tauopathies.
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Tauopathies include neurological disorders such as Alzheimer disease, frontotemporal dementia and progressive supranuclear palsy, in which pathology is heavily associated with toxic accumulation of aberrant tau species, leading tau to aggregate into paired helical filaments and ultimately into neurofibrillary tangles that result in neuronal cell death.
“Tauopathies include neurological disorders, such as Alzheimer disease, frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP)182, in which pathology is heavily associated with toxic accumulation of aberrant tau species, leading tau to aggregate into paired helical filaments and ultimately into neurofibrillary tangles that result in neuronal cell death183.”
From PROTAC targeted protein degraders: the past is prologue (2022) · cites this paper as [183]
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- Authors
- Goedert, M.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Corresponding author
- Goedert, Michel
- ORCID
- Goedert, Michel
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 15
- Issue
- 1
- Pages
- 45-49
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W2061265193
- Cited by
- 177
- References
- 33
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 11 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 4 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 10 · 2013: 10 · 2012: 13
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- tau protein, neurodegeneration, tauopathy, Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, Pick's disease, argyrophilic grain disease, FTDP-17, tau mutations, transgenic animal models, neurofibrillary tangles
- MeSH terms
- Amyloid, Animals, Brain, Dementia, Disease Models, Animal, Glycosaminoglycans, Humans, Mice, Transgenic, Microscopy, Electron, Microtubules, Mutation, Nerve Tissue Proteins, Protein Binding, Supranuclear Palsy, Progressive, tau Proteins, Alternative Splicing, Neurodegenerative Diseases, Protein Isoforms, Parkinsonian Disorders, Pick Disease of the Brain, Tauopathies, Mice
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