Oskar Fischer and the study of dementia
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The centenary of Alois Alzheimer's description of the case of Auguste Deter has renewed interest in the early history of dementia research. In his 1907 paper Alzheimer described the presence of plaques and tangles in one case of presenile dementia. In the same year, Oskar Fischer reported neuritic plaques in 12 cases of senile dementia. These were landmark findings in the history of research in dementia because they delineated the clinicopathological entity that is now known as Alzheimer's disease. Although much has been written about Alzheimer, only little is known about Fischer. The present article discusses Fischer's work on dementia in the context of his life and time.
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Senile amyloid plaques are formed by the extracellular nonvascular accumulation of Aβ40 and Aβ42 peptides that result from abnormal processing of amyloid precursor protein by the β- and γ-secretases and an imbalance in production and clearance pathways.
“Senile amyloid plaques or “miliary foci” as described by Alzheimer in the description of Alzheimer’s disease and originally that same year by Oskar Fischer are formed by the extracellular nonvascular accumulation of Aβ40 and Aβ42 peptides that result from the abnormal processing of amyloid precursor protein by the β- and γ-secretases and an imbalance in the production and clearance pathways [1, 27”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [28]
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- Authors
- Goedert, M.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Corresponding author
- Goedert, M.
- ORCID
- Goedert, M.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-05-21
- Volume
- 132
- Issue
- 4
- Pages
- 1102-1111
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC2668940
- OpenAlex
- W2020592632
- Cited by
- 144
- References
- 54
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 22 · 2023: 12 · 2022: 18 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 3 · 2017: 4 · 2016: 10 · 2015: 7 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Brain (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- MetLife Foundation
- Univerzita Karlova v Praze
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Neurology › Neurology and Historical Studies
- Social Sciences › Arts and Humanities › History and Philosophy of Science › History of Science and Medicine
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alois Alzheimer, Alzheimer's disease, dementia, neuritic plaques, senile dementia, early-onset dementia, clinicopathological correlation
- MeSH terms
- Alzheimer Disease, Brain, Czechoslovakia, Dementia, Neurology, History, 20th Century, Plaque, Amyloid
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