Cited by 156Alzheimer's disease research and treatmentsPrion Diseases and Protein MisfoldingDementia and Cognitive Impairment Research

Invited review: Prion‐like transmission and spreading of tau pathology

Clavaguera, Florence, Hench, Jürgen, Goedert, Michel, Tolnay, Markus·2015·Neuropathology and Applied Neurobiology

Abstract

Filaments made of hyperphosphorylated tau protein are encountered in a number of neurodegenerative diseases referred to as ‘tauopathies’. In the most prevalent tauopathy, A lzheimer's disease, tau pathology progresses in a stereotypical manner with the first lesions appearing in the locus coeruleus and the entorhinal cortex from where they appear to spread to the hippocampus and neocortex. Propagation of tau pathology is also characteristic of argyrophilic grain disease, where the tau lesions appear to spread throughout distinct regions of the limbic system. These findings strongly implicate neurone‐to‐neurone propagation of tau aggregates. Isoform composition and morphology of tau filaments can differ between tauopathies suggesting the existence of conformationally diverse tau strains. Altogether, this points to prion‐like mechanisms in the pathogenesis of tauopathies.

Integrity signals

Registry

Crossref · 10.1111/nan.12197

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  • Tau is primarily an intracellular neuronal protein, but is normally secreted into the interstitial fluid and is believed to transmit tau pathology in a prion-like manner.

    “In the brain, tau is primarily an intracellular neuronal protein, but is normally secreted into the interstitial fluid (ISF)53 and is believed to transmit tau pathology in a prion-like manner54.”

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Authors
Clavaguera, F., Hench, J., Goedert, M., & Tolnay, M.
Affiliations
  • University Hospital of Basel (CH)
  • MRC Laboratory of Molecular Biology (GB)
Corresponding author
Tolnay, Markus
Venue
Neuropathology and Applied Neurobiology
Publisher
Wiley
Published
2015-01-29
Volume
41
Issue
1
Pages
47-58
ISSN
  • 0305-1846 (ISSN-L)
  • 1365-2990
OpenAlex
W1568009558
Cited by
156
References
83
Citations by year
2026: 6 · 2025: 6 · 2024: 8 · 2023: 7 · 2022: 20 · 2021: 13 · 2020: 12 · 2019: 12 · 2018: 21 · 2017: 17 · 2016: 23 · 2015: 11
FWCI
2.00
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropathology and Applied Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Schweizerische Nationalfonds zur Förderung der Wissenschaftlichen Forschung (31003A_152846)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
tauopathy, tau pathology, prion-like transmission, tau aggregation, Alzheimer's disease, argyrophilic grain disease, tau isoforms, neurodegeneration, locus coeruleus, entorhinal cortex, limbic system
MeSH terms
Animals, Brain, Inclusion Bodies, Disease Models, Animal, Humans, Phosphorylation, Prions, Neurofibrillary Tangles, tau Proteins, Disease Progression, Tauopathies, Mice

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