Invited review: Prion‐like transmission and spreading of tau pathology
Abstract
Filaments made of hyperphosphorylated tau protein are encountered in a number of neurodegenerative diseases referred to as ‘tauopathies’. In the most prevalent tauopathy, A lzheimer's disease, tau pathology progresses in a stereotypical manner with the first lesions appearing in the locus coeruleus and the entorhinal cortex from where they appear to spread to the hippocampus and neocortex. Propagation of tau pathology is also characteristic of argyrophilic grain disease, where the tau lesions appear to spread throughout distinct regions of the limbic system. These findings strongly implicate neurone‐to‐neurone propagation of tau aggregates. Isoform composition and morphology of tau filaments can differ between tauopathies suggesting the existence of conformationally diverse tau strains. Altogether, this points to prion‐like mechanisms in the pathogenesis of tauopathies.
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Tau is primarily an intracellular neuronal protein, but is normally secreted into the interstitial fluid and is believed to transmit tau pathology in a prion-like manner.
“In the brain, tau is primarily an intracellular neuronal protein, but is normally secreted into the interstitial fluid (ISF)53 and is believed to transmit tau pathology in a prion-like manner54.”
From Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight (2018) · cites this paper as [54]
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Albayram, Ö., Angeli, P. A., Bernstein, E. R., Baxley, S., Gao, Z. J., Lu, K. P., & Zhou, X. Z. (2018) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000443 · Cited by 19 · see citing works
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Alyenbaawi, H., Allison, W. T., & Mok, S. (2020) · Biomolecules · doi:10.3390/biom10111487 · Cited by 18 · see citing works
Mravec, B., Lejavová, K., Vargovič, P., Ondičová, K., Horváthová, Ľ., Novák, P., Manz, G., Filipčík, P., Novák, M., & Květňanský, R. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0482-1 · Cited by 18 · see citing works
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Espargaró, A., Busquets, M. A., Estelrich, J., & Sabaté, R. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00029 · Cited by 18 · see citing works
Olfactory function in neuropsychiatric disorders
Ryo, Y., Takeuchi, M., Ueda, N., Ohi, K., Kihara, H., Shimada, T., Uehara, T., & Kawasaki, Y. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.02.058 · Cited by 17 · see citing works
Marvian, A. T., Strauß, T., Tang, Q., Tuck, B. J., Keeling, S., Rüdiger, D., Dizaji, N. M., Mohammad‐Beigi, H., Nuscher, B., Chakraborty, P., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00786-w · Cited by 16 · see citing works
- Authors
- Clavaguera, F., Hench, J., Goedert, M., & Tolnay, M.
- Affiliations
- University Hospital of Basel (CH)
- MRC Laboratory of Molecular Biology (GB)
- Corresponding author
- Tolnay, Markus
- Venue
- Neuropathology and Applied Neurobiology
- Publisher
- Wiley
- Published
- 2015-01-29
- Volume
- 41
- Issue
- 1
- Pages
- 47-58
- ISSN
- 0305-1846 (ISSN-L)
- 1365-2990
- OpenAlex
- W1568009558
- Cited by
- 156
- References
- 83
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 8 · 2023: 7 · 2022: 20 · 2021: 13 · 2020: 12 · 2019: 12 · 2018: 21 · 2017: 17 · 2016: 23 · 2015: 11
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropathology and Applied Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Schweizerische Nationalfonds zur Förderung der Wissenschaftlichen Forschung (31003A_152846)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- tauopathy, tau pathology, prion-like transmission, tau aggregation, Alzheimer's disease, argyrophilic grain disease, tau isoforms, neurodegeneration, locus coeruleus, entorhinal cortex, limbic system
- MeSH terms
- Animals, Brain, Inclusion Bodies, Disease Models, Animal, Humans, Phosphorylation, Prions, Neurofibrillary Tangles, tau Proteins, Disease Progression, Tauopathies, Mice
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