Herz, Joachim

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

Shigematsu, H., Lin, L., Takahashi, T., Nomura, M., Suzuki, M., Wistuba, I. I., Fong, K. M., Lee, H., Toyooka, S., Shimizu, N., et al. (2005) · JNCI Journal of the National Cancer Institute

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer Research

Cited by 2,377

Suppression of Aging in Mice by the Hormone Klotho

Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science

Genetics, Aging, and Longevity in Model OrganismsParathyroid Disorders and Treatments

Cited by 1,935

Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2

Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R. E., Richardson, J. A., & Herz, J. (1999) · Cell

Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Cited by 1,261

Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation

Hiesberger, T., Trommsdorff, M., Howell, B. W., Goffinet, A., Mumby, M. C., Cooper, J. A., & Herz, J. (1999) · Neuron

Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Cited by 916

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

Holtzman, D. M., Herz, J., & Bu, G. (2012) · Cold Spring Harbor Perspectives in Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 782

Essential functions of synapsins I and II in synaptic vesicle regulation

Rosahl, T. W., Spillane, D., Missler, M., Herz, J., Selig, D. K., Wolff, J. R., Hammer, R. E., Malenka, R. C., & Südhof, T. C. (1995) · Nature

Neuroscience and Neuropharmacology ResearchCellular transport and secretion

Cited by 719

Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning

Weeber, E. J., Beffert, U., Jones, C., Christian, J. M., Förster, E., Sweatt, J. D., & Herz, J. (2002) · Journal of Biological Chemistry

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 623

Reelin, lipoprotein receptors and synaptic plasticity

Herz, J., & Chen, Y. (2006) · Nature Reviews Neuroscience

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 524

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2

Beffert, U., Weeber, E. J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J. D., Li, W.-P., Adelmann, G., Frotscher, M., Hammer, R. E., et al. (2005) · Neuron

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 497

Lipoprotein receptors in the nervous system

Herz, J., & Bock, H. H. (2002) · Annual Review of Biochemistry

Cholesterol and Lipid MetabolismAlzheimer's disease research and treatments

Cited by 457

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

Rohlmann, A., Gotthardt, M., Hammer, R. E., & Herz, J. (1998) · Journal of Clinical Investigation

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 455

Interactions of the Low Density Lipoprotein Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction

Gotthardt, M., Trommsdorff, M., Nevitt, M. F., Shelton, J., Richardson, J. A., Stockinger, W., Nimpf, J., & Herz, J. (2000) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismReceptor Mechanisms and Signaling

Cited by 450

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

Kowal, R. C., Herz, J., Weisgraber, K. H., Mahley, R. W., Brown, M. S., & Goldstein, J. L. (1990) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 445

The two-receptor model of lipoprotein clearance: tests of the hypothesis in “knockout” mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins

Ishibashi, S., Herz, J., Maeda, N., Goldstein, J. L., & Brown, M. S. (1994) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 430

TDP-43 Is a Developmentally Regulated Protein Essential for Early Embryonic Development

Sephton, C. F., Good, S. K., Atkin, S., Dewey, C. M., Mayer, P., Herz, J., & Yu, G. (2010) · Journal of Biological Chemistry

Amyotrophic Lateral Sclerosis ResearchDevelopmental Biology and Gene Regulation

Cited by 370

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

Chen, Y., Durakoglugil, M. S., Xian, X., & Herz, J. (2010) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 368

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

Liu, Q., Zerbinatti, C. V., Zhang, J., Hoe, H.-S., Wang, B., Cole, S. L., Herz, J., Muglia, L., & Bu, G. (2007) · Neuron

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 364

Reelin-mediated Signaling Locally Regulates Protein Kinase B/Akt and Glycogen Synthase Kinase 3β

Beffert, U., Morfini, G., Bock, H. H., Reyna, H., Brady, S. T., & Herz, J. (2002) · Journal of Biological Chemistry

Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Cited by 306

Reelin modulates NMDA receptor activity in cortical neurons

Chen, Y., Beffert, U., Ertunc, M., Tang, T.-S., Kavalali, E. T., Bezprozvanny, I., & Herz, J. (2005) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 299

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

Ma, Q., Zhao, Z., Sagare, A. P., Wu, Y., Wang, M., Owens, N. C., Verghese, P. B., Herz, J., Holtzman, D. M., & Zlokovic, B. V. (2018) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 281

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors

Willnow, T. E., Rohlmann, A., Horton, J., Otani, H., Braun, J. R., Hammer, R. E., & Herz, J. (1996) · The EMBO Journal

Cholesterol and Lipid MetabolismHeat shock proteins research

Cited by 276

Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.

Frykman, P. K., Brown, M. S., Yamamoto, T., Goldstein, J. L., & Herz, J. (1995) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 256

The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2

Stockinger, W., Brandes, C., Fasching, D., Hermann, M., Gotthardt, M., Herz, J., Schneider, W. J., & Nimpf, J. (2000) · Journal of Biological Chemistry

Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Cited by 239

Reelin signaling directly affects radial glia morphology and biochemical maturation

Hartfuss, E., Förster, E., Bock, H. H., Hack, M. A., Leprince, P., Luque, J. M., Herz, J., Frotscher, M., & Götz, M. (2003) · Development

Neurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal Signaling

Cited by 237