Herz, Joachim

Prosaposin is a regulator of progranulin levels and oligomerization

Nicholson, A. M., Finch, N. A., Almeida, M., Perkerson, R. B., van Blitterswijk, M., Wojtas, A., Cenik, B., Rotondo, S., Inskeep, V., Almasy, L., et al. (2016) · Nature Communications

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 91

The Modular Adaptor Protein Autosomal Recessive Hypercholesterolemia (ARH) Promotes Low Density Lipoprotein Receptor Clustering into Clathrin-coated Pits

Garuti, R., Jones, C., Li, W.-P., Michaely, P., Herz, J., Gerard, R. D., Cohen, J. C., & Hobbs, H. H. (2005) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismCellular transport and secretion

Cited by 91

Lipoprotein and receptor interactions in vivo

Herz, J., & Willnow, T. E. (1995) · Current Opinion in Lipidology

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 88

TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration

Sephton, C. F., Cenik, B., Cenik, B. K., Herz, J., & Yu, G. (2012) · bchm

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 86

Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-d-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes

Nakajima, C., Kulik, A., Frotscher, M., Herz, J., Schäfer, M., Bock, H. H., & May, P. (2013) · Journal of Biological Chemistry

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 85

ApoE receptor 2 controls neuronal survival in the adult brain

Beffert, U., Nematollah Farsian, F., Masiulis, I., Hammer, R. E., Yoon, S. O., Giehl, K. M., & Herz, J. (2006) · Current Biology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 84

Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation

Leemhuis, J., Bouché, E., Frotscher, M., Henle, F., Hein, L., Herz, J., Meyer, D. K., Pichler, M., Roth, G., Schwan, C., et al. (2010) · The Journal of Neuroscience

Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Cited by 80

Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation

Ding, Y., Huang, L., Xian, X., Yuhanna, I. S., Wasser, C. R., Frotscher, M., Mineo, C., Shaul, P. W., & Herz, J. (2016) · Science Signaling

Atherosclerosis and Cardiovascular DiseasesCell Adhesion Molecules Research

Cited by 72

APP interacts with LRP4 and Agrin to coordinate the development of the neuromuscular junction in mice

Choi, H. Y., Liu, Y., Tennert, C., Sugiura, Y., Karakatsani, A., Kröger, S., Johnson, E. B., Hammer, R. E., Lin, W., & Herz, J. (2013) · eLife

Nicotinic Acetylcholine Receptors StudyAlzheimer's disease research and treatments

Cited by 71

Defective splicing of Megf7/Lrp4, a regulator of distal limb development, in autosomal recessive mulefoot disease

Johnson, E. B., Steffen, D. J., Lynch, K. W., & Herz, J. (2006) · Genomics

Congenital limb and hand anomaliesGenetic and phenotypic traits in livestock

Cited by 62

Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation – a mouse model for Cenani–Lenz syndrome

Karner, C. M., Dietrich, M. F., Johnson, E. B., Kappesser, N., Tennert, C., Percin, F., Wollnik, B., Carroll, T. J., & Herz, J. (2010) · PLoS ONE

Renal and related cancersDevelopmental Biology and Gene Regulation

Cited by 57

Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer’s Disease

Vance, J. M., Farrer, L. A., Huang, Y., Cruchaga, C., Hyman, B. T., Pericak‐Vance, M. A., Goate, A. M., Greicius, M. D., Griswold, A. J., Haines, J. L., et al. (2024) · Annals of Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 52

The Reelin Receptors Apoer2 and Vldlr Coordinate the Patterning of Purkinje Cell Topography in the Developing Mouse Cerebellum

Larouche, M., Beffert, U., Herz, J., & Hawkes, R. (2008) · PLoS ONE

Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Cited by 49

Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning

Wasser, C. R., Masiulis, I., Durakoglugil, M. S., Lane-Donovan, C., Xian, X., Beffert, U., Agarwala, A., Hammer, R. E., & Herz, J. (2014) · Science Signaling

Neuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments

Cited by 48

NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load

Pohlkamp, T., Xian, X., Wong, C. H., Durakoglugil, M. S., Werthmann, G. C., Saido, T. C., Evers, B. M., White, C. L., Connor, J., Hammer, R. E., et al. (2021) · eLife

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 46

LRP1 Controls cPLA2 Phosphorylation, ABCA1 Expression and Cellular Cholesterol Export

Zhou, L., Choi, H. Y., Li, W.-P., Xu, F., & Herz, J. (2009) · PLoS ONE

Cholesterol and Lipid MetabolismDrug Transport and Resistance Mechanisms

Cited by 45

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., Carrillo, M. C., Chen, X., Chiba‐Falek, O., Davis, A. A., Paolo, G. D., Garretti, F., et al. (2024) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 33

Lrp4 domains differentially regulate limb/brain development and synaptic plasticity

Pohlkamp, T., Durakoglugil, M., Lane-Donovan, C., Xian, X., Johnson, E. B., Hammer, R. E., & Herz, J. (2015) · PLOS ONE

Neuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments

Cited by 28

Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression

Moreno-Yruela, C., Fass, D. M., Cheng, C., Herz, J., Olsen, C. A., & Haggarty, S. J. (2019) · ACS Chemical Neuroscience

Histone Deacetylase Inhibitors ResearchAlzheimer's disease research and treatments

Cited by 27