Vendruscolo, Michele

The amyloid state and its association with protein misfolding diseases.

Knowles, T. P. J., Vendruscolo, M., & Dobson, C. M. (2014) · Nature Reviews Molecular Cell Biology

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 2,382

The Amyloid-β Pathway in Alzheimer’s Disease

Hampel, H., Hardy, J., Blennow, K., Chen, C., Perry, G., Kim, S. H., Villemagne, V. L., Aisen, P., Vendruscolo, M., Iwatsubo, T., et al. (2021) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,952

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

Galvagnion, C., Buell, A. K., Meisl, G., Michaels, T. C. T., Vendruscolo, M., Knowles, T. P. J., & Dobson, C. M. (2015) · Nature Chemical Biology

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 661

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

Walther, D. M., Kasturi, P., Zheng, M., Pinkert, S., Vecchi, G., Ciryam, P., Morimoto, R. I., Dobson, C. M., Vendruscolo, M., Mann, M., et al. (2015) · Cell

Genetics, Aging, and Longevity in Model OrganismsHeat shock proteins research

Cited by 569

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

Liao, Y.-C., Fernandopulle, M. S., Wang, G., Choi, H., Hao, L., Drerup, C. M., Patel, R., Qamar, S., Nixon-Abell, J., Shen, Y., et al. (2019) · Cell

RNA Research and SplicingCellular transport and secretion

Cited by 550

The CamSol method of rational design of protein mutants with enhanced solubility

Sormanni, P., Aprile, F. A., & Vendruscolo, M. (2015) · Journal of Molecular Biology

Protein Structure and DynamicsProtein purification and stability

Cited by 494

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

De, S., Wirthensohn, D. C., Flagmeier, P., Hughes, C., Aprile, F. A., Ruggeri, F. S., Whiten, D. R., Emin, D., Xia, Z., Varela, J. A., et al. (2019) · Nature Communications

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 448

Critical assessment of protein intrinsic disorder prediction

Necci, M., Piovesan, D., Predictors, C., Hoque, M. T., Walsh, I., Iqbal, S., Vendruscolo, M., Sormanni, P., Wang, C., Raimondi, D., et al. (2021) · Nature Methods

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 343

Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins

Ciryam, P., Tartaglia, G. G., Morimoto, R. I., Dobson, C. M., & Vendruscolo, M. (2013) · Cell Reports

Heat shock proteins researchProtein purification and stability

Cited by 270

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Kelmer Sacramento, E., Kirkpatrick, J. M., Mazzetto, M., Baumgart, M., Bartolome, A., Di Sanzo, S., Caterino, C., Sanguanini, M., Papaevgeniou, N., Lefaki, M., et al. (2020) · Molecular Systems Biology

Genetics, Aging, and Longevity in Model OrganismsUbiquitin and proteasome pathways

Cited by 236

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Sacramento, E. K., Kirkpatrick, J. M., Mazzetto, M., Baumgart, M., Bartolome, A., Di Sanzo, S., Caterino, C., Sanguanini, M., Papaevgeniou, N., Lefaki, M., et al. (2019) · Molecular Systems Biology

Genetics, Aging, and Longevity in Model OrganismsUbiquitin and proteasome pathways

Cited by 236

Parapred: antibody paratope prediction using convolutional and recurrent neural networks

Liberis, E., Veličković, P., Sormanni, P., Vendruscolo, M., & Liò, P. (2018) · Bioinformatics

Machine Learning in Bioinformaticsvaccines and immunoinformatics approaches

Cited by 165

Relation between native ensembles and experimental structures of proteins

Best, R. B., Lindorff-Larsen, K., DePristo, M. A., & Vendruscolo, M. (2006) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsAdvanced NMR Techniques and Applications

Cited by 152

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

Tóth, G., Gardai, S. J., Zago, W., Bertoncini, C. W., Cremades, N., Roy, S. L., Tambe, M. A., Rochet, J.-C., Galvagnion, C., Skibinski, G., et al. (2014) · PLoS ONE

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 151

Characterization of the free-energy landscapes of proteins by NMR-guided metadynamics

Granata, D., Camilloni, C., Vendruscolo, M., & Laio, A. (2013) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsAdvanced Physical and Chemical Molecular Interactions

Cited by 143

Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

Brewer, K. D., Bacaj, T., Cavalli, A., Camilloni, C., Swarbrick, J. D., Liu, J., Zhou, A., Zhou, P., Barlow, N., Xu, J., et al. (2015) · Nature Structural & Molecular Biology

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 142

AlphaFold prediction of structural ensembles of disordered proteins

Brotzakis, Z. F., Zhang, S., Murtada, M. H., & Vendruscolo, M. (2025) · Nature Communications

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 99

In vitro and in silico assessment of the developability of a designed monoclonal antibody library

Wolf Pérez, A.-M., Sormanni, P., Andersen, J. S., Sakhnini, L. I., Rodriguez-Leon, I., Bjelke, J. R., Gajhede, A. J., De Maria, L., Otzen, D. E., Vendruscolo, M., et al. (2019) · mAbs

Monoclonal and Polyclonal Antibodies ResearchProtein purification and stability

Cited by 97

A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms

Brotzakis, Z. F., Lindstedt, P. R., Taylor, R. J., Rinauro, D. J., Gallagher, N. C. T., Bernardes, G. J. L., & Vendruscolo, M. (2021) · ACS Central Science

Alzheimer's disease research and treatmentsProtein Structure and Dynamics

Cited by 70

The A53T Mutation is Key in Defining the Differences in the Aggregation Kinetics of Human and Mouse α-Synuclein

Kang, L., Wu, K.-P., Vendruscolo, M., & Baum, J. (2011) · Journal of the American Chemical Society

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 65

A relationship between mRNA expression levels and protein solubility in E. coli

Tartaglia, G. G., Pechmann, S., Dobson, C. M., & Vendruscolo, M. (2009) · Journal of Molecular Biology

Protein purification and stabilityRNA and protein synthesis mechanisms

Cited by 63

A kinetic ensemble of the Alzheimer’s Aβ peptide

Löhr, T., Kohlhoff, K., Heller, G. T., Camilloni, C., & Vendruscolo, M. (2021) · Nature Computational Science

Protein Structure and DynamicsAlzheimer's disease research and treatments

Cited by 57

Fragment-based computational design of antibodies targeting structured epitopes

Aguilar Rangel, M., Bedwell, A., Costanzi, E., Taylor, R. J., Russo, R., Bernardes, G. J. L., Ricagno, S., Frydman, J., Vendruscolo, M., & Sormanni, P. (2022) · Science Advances

Monoclonal and Polyclonal Antibodies Researchvaccines and immunoinformatics approaches

Cited by 55

Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases

Limbocker, R., Cremades, N., Cascella, R., Tessier, P. M., Vendruscolo, M., & Chiti, F. (2023) · Accounts of Chemical Research

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 48