State and trait anxiety and depression in patients affected by gastrointestinal diseases: psychometric evaluation of 1641 patients referred to an internal medicine outpatient setting: Affective disorders in gastrointestinal diseases
Abstract
OBJECTIVES: To evaluate state and trait form of anxiety and current depression in patients affected by gastrointestinal diseases. METHODS: We studied 1641 outpatients with gastrointestinal disorders, consecutively referred to our Internal Medicine outpatients from 1997 to 2005. State and trait anxiety were assessed by the State and Trait Anxiety Inventory. Current depression was assessed by the Zung self-rating depression scale. RESULTS: Among patients, 1379 (84.1%) showed state anxiety, 1098 (67%) showed trait anxiety and 442 (27%) showed current depression. The number of gastrointestinal diseases was directly correlated to state anxiety (p < 0.001) and trait anxiety (p = 0.04). Females showed higher levels of anxiety and depression than males (p < 0.001). State anxiety was related to food allergies (p < 0.001), small intestinal bacterial overgrowth (SIBO) (p = 0.001), Hp infection (p = 0.01) and ulcerative colitis in active phase (p = 0.03). Trait anxiety was related to irritable bowel syndrome (IBS) (p < 0.001), Helicobacter pylori (Hp) infection (p = 0.001), food allergies (p = 0.001) and SIBO (p = 0.001). Current depression was related to IBS (p < 0.001) and coeliac disease (p = 0.01), SIBO (p = 0.02). A predicted probability of 0.77 +/- 0.16 to have state anxiety, of 0.66 +/- 0.12 to have trait anxiety and of 0.39 +/- 0.14 to have depression was found in these patients. CONCLUSIONS: Most of the patients who seek medical consultation for gastrointestinal problems show an associated affective disorder. These patients should be managed by a team including gastroenterologists, psychologists and/or psychiatrists, or by a gastroenterologist having expertise in the treatment of psychological disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The pooled mean rate of anxiety in inactive IBD across studies reporting percentages was 28.2% (95% CI ±2.7).
“The pooled mean rate for all the studies reporting percentages (study n=8; total n=1,069) was 28.2% (± 2.7, 95% CI) (18, 27-29, 32, 33, 36, 39).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [27]
The pooled mean rate of depressive symptoms for inactive IBD was 19.9% (95% CI ±2.05).
“The pooled mean rate of depressive symptoms for those with inactive IBD was 19.9% (± 2.05, 95% CI) (study n=10; total n=1,132) (18, 27-29, 32, 33, 36, 39, 40, 48).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [27]
The pooled mean rate of depressive symptoms during active IBD was 34.7%.
“The pooled mean rate of depressive symptoms during active IBD was 34.7% (study n=5; total n=319) (18, 27, 29, 40, 48).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [27]
Of 15 studies with applicable data, 11 reported significantly higher rates or levels of anxiety in active IBD compared to inactive IBD.
“Of the remaining 15, 11 reported significantly higher rates or levels of anxiety in participants with active IBD compared to those with inactive IBD (n=13,585) (4, 18, 20, 27, 29, 31, 38, 41, 42, 44, 45).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [27]
Of 17 studies with applicable data, 12 reported significantly higher rates or levels of depression for active IBD compared to inactive IBD.
“Of the remaining 17 studies, 12 reported significantly higher rates or levels of depression for those with active IBD (n=13,553) (18, 20, 27, 29, 31, 34, 35, 38, 41, 43, 45, 48).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1970) · Cited by 24,983 · see citing works
DiMatteo, M. R., Lepper, H. S., & Croghan, T. W. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.14.2101 · Cited by 4,177 · see citing works
A SIMPLE INDEX OF CROHN'S-DISEASE ACTIVITY
Harvey, R. F., & Bradshaw, J. M. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92767-1 · Cited by 2,974 · see citing works
Cortisone in Ulcerative Colitis
Truelove, S. C., & Witts, L. J. (1955) · BMJ · doi:10.1136/bmj.2.4947.1041 · Cited by 2,793 · see citing works
Malfertheiner, P., Mégraud, F., O'Morain, C. A., Hungin, A. P. S., Jones, R. H., Axon, A. T. R., Graham, D. Y., Tytgat, G. N. J., & The European Helicobacter Pylori Study Group (EHPSG) (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01169.x · Cited by 1,238 · see citing works
Prevalence and incidence studies of anxiety disorders: A systematic review of the literature
Somers, J. M., Goldner, E. M., Waraich, P., & Hsu, L. (2006) · The Canadian Journal of Psychiatry · doi:10.1177/070674370605100206 · Cited by 1,114 · see citing works
Self-Rating Depression Scale in an Outpatient Clinic
Zung, W. W. K. (1965) · Archives of General Psychiatry · doi:10.1001/archpsyc.1965.01730060026004 · Cited by 1,075 · see citing works
Psychosocial Aspects of the Functional Gastrointestinal Disorders
Levy, R. L., Olden, K. W., Naliboff, B. D., Bradley, L. A., Francisconi, C., Drossman, D. A., & Creed, F. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.057 · Cited by 776 · see citing works
Drossman, D. A., Toner, B. B., Whitehead, W. E., Diamant, N. E., Dalton, C. B., Duncan, S., Emmott, S., Proffitt, V., Akman, D., Frusciante, K., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00669-3 · Cited by 614 · see citing works
Prevalence and Incidence Studies of Mood Disorders: A Systematic Review of the Literature
Waraich, P., Goldner, E. M., Somers, J. M., & Hsu, L. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404900208 · Cited by 522 · see citing works
Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis
Jackson, J. L., O’Malley, P. G., Tomkins, G., Balden, E., Santoro, J., & Kroenke, K. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00299-5 · Cited by 464 · see citing works
Gastro-oesophageal reflux disease
Moayyedi, P., & Talley, N. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68932-0 · Cited by 433 · see citing works
Diagnosis of fatty liver disease
Joy, D., Thava, V. R., & SCOTT, B. B. (2003) · European Journal of Gastroenterology & Hepatology · doi:10.1097/01.meg.0000059112.41030.2e · Cited by 341 · see citing works
Long term benefits of hypnotherapy for irritable bowel syndrome
Gonsalkorale, W. M., Miller, V, Afzal, A., & Whorwell, P. J. (2003) · Gut · doi:10.1136/gut.52.11.1623 · Cited by 283 · see citing works
Chochinov, H. M. (2001) · The Lancet Oncology · doi:10.1016/s1470-2045(01)00456-9 · Cited by 271 · see citing works
Costs of Irritable Bowel Syndrome in the UK and US
Maxion‐Bergemann, S., Thielecke, F., Abel, F., & Bergemann, R. (2006) · PharmacoEconomics · doi:10.2165/00019053-200624010-00002 · Cited by 261 · see citing works
Koloski, N. A., Talley, N. J., & Boyce, P. M. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03789.x · Cited by 253 · see citing works
Addolorato, G., Capristo, E., Stefanini, G. F., & Gasbarrini, A. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709011218 · Cited by 243 · see citing works
Self-citationNucera, G., Gabrielli, M., Lupascu, A., Lauritano, E. C., Santoliquido, A., Cremonini, F., Cammarota, G., Tondi, P., Pola, P., Gasbarrini, G., et al. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02493.x · Cited by 204 · see citing works
Self-citationFear-potentiated startle: Relationship to the level of state/trait anxiety in healthy subjects
Grillon, C., Ameli, R., Foot, M., & Davis, M. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90094-t · Cited by 197 · see citing works
Payne, A., & Blanchard, E. B. (1995) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.63.5.779 · Cited by 186 · see citing works
Addolorato, G., Capristo, E., Ghittoni, G., Valeri, C., Mascianà, R., Ancona, C., & Gasbarrini, G. (2001) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520119754 · Cited by 181 · see citing works
Self-citationSmith, R. C., Greenbaum, D. S., Vancouver, J. B., HENRY, R. C., Reinhart, M. A., Greenbaum, R. B., Dean, H. A., & Mayle, J. E. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90817-k · Cited by 171 · see citing works
Do psychosocial factors define symptom severity and patient status in irritable bowel syndrome?
Drossman, D. A. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00081-9 · Cited by 168 · see citing works
Payne, A., & Blanchard, E. B. (1995) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.63.5.779 · Cited by 166 · see citing works
SIMPLE INDEX OF CROHN'S DISEASE ACTIVITY
Elliott, P., Lennard‐Jones, J. E., & Hathway, N. R. (1980) · The Lancet · doi:10.1016/s0140-6736(80)91372-0 · Cited by 127 · see citing works
Addolorato, G., Lorenzi, G. D., Abenavoli, L., Leggio, L., Capristo, E., & Gasbarrini, A. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02193.x · Cited by 116 · see citing works
Self-citationComparison of Eight Psychometric Instruments in Unselected Patients with Back Pain
Greenough, C. G., & Fraser, R. D. (1991) · Spine · doi:10.1097/00007632-199109000-00010 · Cited by 110 · see citing works
Are gender differences in depression explained by gender differences in co-morbid anxiety?
Simonds, V. M. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00113-1 · Cited by 107 · see citing works
Psychological and emotional aspects of gastroesophageal reflux disease
Kamolz, T., & Velanovich, V. (2002) · Diseases of the Esophagus · doi:10.1046/j.1442-2050.2002.00261.x · Cited by 105 · see citing works
Controversies in liver biopsy: Who, where, when, how, why?
Friedman, L. S. (2004) · Current Gastroenterology Reports · doi:10.1007/s11894-004-0023-4 · Cited by 104 · see citing works
Fernández‐Bañares, F., Rosinach, M., Esteve, M., Forné, M., Espinós, J. C., & Viver, J. M. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2005.11.010 · Cited by 96 · see citing works
Utility of the Rome I and Rome II criteria for irritable bowel syndrome in U.S. women
Chey, W. D., Olden, K. W., Carter, E., Boyle, J. M., Drossman, D. A., & Chang, L. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.07026.x · Cited by 93 · see citing works
Addolorato, G., Marsigli, L., Capristo, E., Caputo, F., Dall'Aglio, C., & Baudanza, P. (1998) · PubMed · Cited by 89 · see citing works
Self-citationAddolorato, G., Stefanini, G. F., Capristo, E., Caputo, F., Gasbarrini, A., & Gasbarrini, A. (1996) · PubMed · Cited by 88 · see citing works
Self-citationFood allergy diagnostics: scientific and unproven procedures
Beyer, K., & Teuber, S. S. (2005) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/01.all.0000168792.27948.f9 · Cited by 83 · see citing works
Weinstein, A. M. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00249-3 · Cited by 69 · see citing works
Cheng, C. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200011000-00015 · Cited by 64 · see citing works
Who comes to a voluntary depression screening program?
Magruder, K. M., NORQUIST, G. S., Feil, M., Kopans, B., & Jacobs, D. G. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.11.1615 · Cited by 64 · see citing works
Urita, Y. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i19.3092 · Cited by 31 · see citing works
van Kerkhoven, L. A. S., van Rossum, L. G. M., van Oijen, M. G. H., Witteman, E. M., Jansen, J. B. �. �., Laheij, R. J. F., & Tan, A. C. I. T. L. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02435.x · Cited by 20 · see citing works
Ålander, T., Svärdsudd, K., & Agréus, L. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01549.x · Cited by 19 · see citing works
THE PSYCHOLOGIC DISTRESS IN PATIENTS WITH CANCER
Sivesind, D., & Baile, W. F. (2001) · Nursing Clinics of North America · doi:10.1016/s0029-6465(22)02673-1 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228 · see citing works
Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M. M., Rajilić-Stojanović, M. D., Schemann, M., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.14 · Cited by 1,057 · see citing works
Barberio, B., Zamani, M., Black, C. J., Savarino, E. V., & Ford, A. C. (2021) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(21)00014-5 · Cited by 758 · see citing works
Mikocka-Walus, A., Knowles, S. R., Keefer, L., & Graff, L. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000620 · Cited by 567 · see citing works
Van Oudenhove, L., Levy, R. L., Crowell, M. D., Drossman, D. A., Halpert, A. D., Keefer, L., Lackner, J. M., Murphy, T. B., & Naliboff, B. D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.027 · Cited by 512 · see citing works
Wang, J., Wu, X., Lai, W., Long, E., Zhang, X., Li, W., Zhu, Y., Chen, C., Zhong, X., Liu, Z., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-017173 · Cited by 486 · see citing works
Koloski, N. A., Jones, M., & Talley, N. J. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13738 · Cited by 318 · see citing works
Microbiota regulation of the mammalian gut-brain axis
Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300 · see citing works
Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?
Bowe, W. P., & Logan, A. C. (2011) · Gut Pathogens · doi:10.1186/1757-4749-3-1 · Cited by 292 · see citing works
Spiller, R. E., Humes, D. J., Campbell, E., Hastings, M. C., Neal, K. R., Dukes, G. E., & Whorwell, P. J. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04402.x · Cited by 236 · see citing works
The “psychomicrobiotic”: targeting microbiota in major psychiatric disorders: a systematic review
Fond, G., Boukouaci, W., Chevalier, G., Regnault, A., Eberl, G., Hamdani, N., Dickerson, F., Macgregor, A., Boyer, L., Dargel, A., et al. (2015) · Pathologie Biologie · doi:10.1016/j.patbio.2014.10.003 · Cited by 219 · see citing works
Abautret-Daly, Á., Dempsey, E., Parra‐Blanco, A., Medina, C., & Harkin, A. (2017) · Acta Neuropsychiatrica · doi:10.1017/neu.2017.3 · Cited by 185 · see citing works
Pain and depression comorbidity: A preclinical perspective
Li, J. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.042 · Cited by 170 · see citing works
Increased Risks of Developing Anxiety and Depression in Young Patients With Crohn's Disease
Loftus, E. V., Guérin, A., Yu, A. P., Wu, E. Q., Yang, M., Chao, J., & Mulani, P. M. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.142 · Cited by 142 · see citing works
Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine
Bowe, W. P., Patel, N., & Logan, A. C. (2013) · Beneficial Microbes · doi:10.3920/bm2012.0060 · Cited by 145 · see citing works
Bested, A. C., Logan, A. C., & Selhub, E. M. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-3 · Cited by 121 · see citing works
Meta‐analysis on anxiety and depression in adult celiac disease
Smith, D. F., & Gerdes, L. U. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01795.x · Cited by 114 · see citing works
Anxiety and depressive symptoms and medical illness among adults with anxiety disorders
Niles, A. N., Dour, H. J., Stanton, A. L., Roy‐Byrne, P., Stein, M. B., Sullivan, G., Sherbourne, C. D., Rose, R. D., & Craske, M. G. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.11.018 · Cited by 105 · see citing works
Holtmann, G., & Talley, N. J. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.10.001 · Cited by 91 · see citing works
Gut microbiota regulates key modulators of social behavior
Parashar, A., & Udayabanu, M. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.11.002 · Cited by 88 · see citing works
Coeliac disease, diet adherence and depressive symptoms
van Hees, N. J. M., van der Does, W. A. J., & Giltay, E. J. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2012.11.007 · Cited by 88 · see citing works
Factors affecting consumers' adherence to gluten-free diet, a systematic review
Xhakollari, V., Canavari, M., & Osman, M. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.12.005 · Cited by 90 · see citing works
Sainsbury, K., Mullan, B., & Sharpe, L. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2013.05.011 · Cited by 83 · see citing works
Zhang, M., Hong, L., Zhang, T., Lin, Y., Zheng, S., Zhou, X., Fan, R., Wang, Z., Zhang, C.-L., & Zhong, J. (2016) · Patient Preference and Adherence · doi:10.2147/ppa.s118413 · Cited by 76 · see citing works
Quality of life in a cohort of high-dose benzodiazepine dependent patients
Lugoboni, F., Mirijello, A., Faccini, M., Casari, R., Cossari, A., Musi, G., Bissoli, G. C., Quaglio, G., & Addolorato, G. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.06.020 · Cited by 77 · see citing works
Self-citationShen, L., Kong, H., & Hou, X. (2009) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2009.05943.x · Cited by 76 · see citing works
Bouchoucha, M. L., Hejnar, M., Devroede, G. J., Babba, T., Bon, C., & Benamouzig, R. (2012) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2012.10.011 · Cited by 74 · see citing works
Gluten-Free Diet and Other Celiac Disease Therapies: Current Understanding and Emerging Strategies
Mazzola, A. M., Zammarchi, I., Valerii, M. C., Spisni, E., Saracino, I. M., Lanzarotto, F., & Ricci, C. (2024) · Nutrients · doi:10.3390/nu16071006 · Cited by 99 · see citing works
The quality of sleep in patients with coeliac disease
Zingone, F., Siniscalchi, M., Capone, P., Tortora, R., Andreozzi, P., Capone, E., & Ciacci, C. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04432.x · Cited by 72 · see citing works
Slim, M., Calandre, E. P., & Rico‐Villademoros, F. (2014) · Rheumatology International · doi:10.1007/s00296-014-3109-9 · Cited by 69 · see citing works
Flux, M. C., & Lowry, C. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104578 · Cited by 68 · see citing works
Söderquist, F., Syk, M., Just, D., Novičić, Z. K., Rasmusson, A. J., Hellström, P. M., Ramklint, M., & Cunningham, J. L. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02940-2 · Cited by 63 · see citing works
Ross, K. (2023) · EXPLORE · doi:10.1016/j.explore.2023.02.007 · Cited by 59 · see citing works
Midenfjord, I., Borg, A., Törnblom, H., & Simrén, M. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001038 · Cited by 57 · see citing works
Zhang, A., Wang, Q.-C., Huang, K., Huang, J.-G., Zhou, C., Sun, F., Wang, S.-W., & Wu, F. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i42.9437 · Cited by 41 · see citing works
The progression of coeliac disease: its neurological and psychiatric implications
Campagna, G., Pesce, M., Tatangelo, R., Rizzuto, A., Fratta, I. L., & Grilli, A. (2016) · Nutrition Research Reviews · doi:10.1017/s0954422416000214 · Cited by 50 · see citing works
van Hees, N. J. M., Giltay, E. J., Tielemans, S. M. A. J., Geleijnse, J. M., Puvill, T., Janssen, N., & van der Does, W. A. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122619 · Cited by 44 · see citing works
Rhinitis as an associated factor for anxiety and depression amongst adults
Bedolla‐Barajas, M., Morales‐Romero, J., Pulido‐Guillén, N. A., Robles‐Figueroa, M., & Plascencia‐Domínguez, B. R. (2016) · Brazilian Journal of Otorhinolaryngology · doi:10.1016/j.bjorl.2016.05.008 · Cited by 42 · see citing works
Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats
Luo, J., Wang, T., Liang, S., Hu, X., Li, W., & Jin, F. (2013) · Behavioral and Brain Functions · doi:10.1186/1744-9081-9-46 · Cited by 41 · see citing works
Determinants of Quality of Life in High-Dose Benzodiazepine Misusers
Tamburin, S., Federico, A., Faccini, M., Casari, R., Morbioli, L., Sartore, V., Mirijello, A., Addolorato, G., & Lugoboni, F. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14010038 · Cited by 38 · see citing works
Self-citationRole of Trait Anxiety in Persistent Radicular Pain After Surgery for Lumbar Disc Herniation
D’Angelo, C., Mirijello, A., Ferrulli, A., Leggio, L., Berardi, A., Icolaro, N., Miceli, A., D’Angelo, V., Gasbarrini, A., & Addolorato, G. (2010) · Neurosurgery · doi:10.1227/01.neu.0000371971.51755.1c · Cited by 36 · see citing works
Self-citationNeufeld, N. H., Mohamed, N. S., Grujich, N., & SHULMAN, K. (2017) · Journal of Psychiatric Practice · doi:10.1097/pra.0000000000000205 · Cited by 35 · see citing works
Ben‐Azu, B., del Re, E. C., VanderZwaag, J., Carrier, M., Keshavan, M. S., Khakpour, M., & Tremblay, M. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1139357 · Cited by 32 · see citing works
Zylberberg, H. M., Demmer, R. T., Murray, J. A., Green, P. H. R., & Lebwohl, B. (2017) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000932 · Cited by 32 · see citing works
Modulation of Gut-Brain Axis by Probiotics: A Promising Anti-depressant Approach
Rajanala, K., Kumar, N., & Chamallamudi, M. R. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666201215142520 · Cited by 32 · see citing works
Carpinelli, L., Bucci, C., Santonicola, A., Zingone, F., Ciacci, C., & Iovino, P. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13531 · Cited by 31 · see citing works
Oliviero, G., Ruggiero, L., D'Antonio, E., Gagliardi, M., Nunziata, R., Sarno, A. D., Abbatiello, C., Feo, E. D., Vivo, S. D., Santonicola, A., et al. (2021) · Neurogastroenterology & Motility · doi:10.1111/nmo.14092 · Cited by 30 · see citing works
Bouchoucha, M. L., Hejnar, M., Devroede, G. J., Boubaya, M., Bon, C., & Benamouzig, R. (2013) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.10.009 · Cited by 29 · see citing works
Soylu, D., & Kartin, P. T. (2021) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2021.101304 · Cited by 29 · see citing works
Risk Assessment in Cholelithiasis: Is Cholecystectomy Always to be Preferred?
Mertens, M. C., Roukema, J. A., Scholtes, V. P. W., & Vries, J. D. (2010) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-010-1219-6 · Cited by 29 · see citing works
Abdi, A., Oroojzadeh, P., Valivand, N., Sambrani, R., & Lotfi, H. (2024) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2024.149632 · Cited by 27 · see citing works
Porcelli, B., Verdino, V., Bossini, L., Terzuoli, L., & Fagiolini, A. M. (2014) · Autoimmunity Highlights · doi:10.1007/s13317-014-0064-0 · Cited by 28 · see citing works
Drabińska, N., Krupa‐Kozak, U., Ciska, E., & Jarocka‐Cyrta, E. (2018) · Amino Acids · doi:10.1007/s00726-018-2622-7 · Cited by 27 · see citing works
Prevalence of depressive and anxiety disorders in Chinese gastroenterological outpatients
Li, X. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i20.2561 · Cited by 27 · see citing works
Anxiety and Gastrointestinal Symptoms Related to COVID-19 during Italian Lockdown
Abenavoli, L., Cinaglia, P., Lombardo, G., Boffoli, E., Scida, M., Procopio, A. C., Larussa, T., Boccuto, L., Zanza, C., Longhitano, Y., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061221 · Cited by 23 · see citing works
Self-citationHay, E. M., Dziedzic, K., Foster, N. E., Peat, G., van der Windt, D., Bartlam, B., Bucknall, M., Edwards, J., Healey, E. L., Holden, M. A., et al. (2018) · Programme Grants for Applied Research · doi:10.3310/pgfar06040 · Cited by 23 · see citing works
Lugoboni, F., Mirijello, A., Zamboni, L., Faccini, M., Casari, R., Cossari, A., Gasbarrini, A., Addolorato, G., & on behalf of, G. I. C. S. (2016) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2016.1232391 · Cited by 22 · see citing works
Self-citationYu, Y., Wang, Q., Qi, F., Song, X., Di, J., Zhang, L., Zhou, Y., Lu, X., & Chang, J. (2018) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.199431 · Cited by 22 · see citing works
Drabińska, N. (2022) · Separations · doi:10.3390/separations9030081 · Cited by 22 · see citing works
Rostami‐Nejad, M., Taraghikhah, N., Ciacci, C., Pourhoseingholi, M. A., Barzegar, F., Rezaei–Tavirani, M., Aldulaimi, D., & Zali, M. R. (2020) · Inflammatory Intestinal Diseases · doi:10.1159/000505657 · Cited by 22 · see citing works
Classification of gastrointestinal symptom patterns in young adults
Vivier, H., Ross, E. J., & Cassisi, J. E. (2020) · BMC Gastroenterology · doi:10.1186/s12876-020-01478-7 · Cited by 20 · see citing works
van Hees, N. J. M., Giltay, E. J., Geleijnse, J. M., Janssen, N., & van der Does, W. A. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097778 · Cited by 19 · see citing works
Chu, H., Fox, M. R., Zheng, X., Deng, Y., Long, Y., Huang, Z., Du, L., Xu, F., & Dai, N. (2016) · Gastroenterology Research and Practice · doi:10.1155/2016/3230859 · Cited by 19 · see citing works
Kossewska, J., Bierlit, K., & Trajkovski, V. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20010093 · Cited by 18 · see citing works
Rohde, J. A., Barker, J., & Noar, S. M. (2019) · Translational Behavioral Medicine · doi:10.1093/tbm/ibz166 · Cited by 17 · see citing works
COVID-19 and Inflammatory Bowel Disease: Patient Knowledge and Perceptions in a Single Center Survey
Spagnuolo, R., Larussa, T., Iannelli, C., Cosco, C., Nisticò, E., Manduci, E., Bruno, A., Boccuto, L., Abenavoli, L., Luzza, F., et al. (2020) · Medicina · doi:10.3390/medicina56080407 · Cited by 16 · see citing works
Self-citationLaw, M., Pickering, I., Humphrey, G., Sebaratnam, G., Schamberg, G., Simpson, K., Varghese, C., Du, P., Daker, C., Huang, I., et al. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1389671 · Cited by 17 · see citing works
Takagishi, Y., Sakata, M., & Kitamura, T. (2011) · Journal of Clinical Psychology · doi:10.1002/jclp.20815 · Cited by 12 · see citing works
Development of a Risk Score for Extraintestinal Manifestations of Coeliac Disease
Chiu, C. L., Hearn, N. L., & Lind, J. M. (2016) · Medicine · doi:10.1097/md.0000000000003286 · Cited by 14 · see citing works
Riehl, M. E., Kinnucan, J. A. R., Chey, W. D., & Stidham, R. W. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13663 · Cited by 14 · see citing works
Association between small intestine bacterial overgrowth and psychiatric disorders
Bogielski, B., Michalczyk, K., Głodek, P., Tempka, B., Gębski, W., & Stygar, D. M. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1438066 · Cited by 13 · see citing works
Renemane, L., Ķīvīte‐Urtāne, A., & Rancāns, E. (2021) · Medicina · doi:10.3390/medicina57090970 · Cited by 12 · see citing works
Trait Anxiety Predicts Unsuccessful Surgery in Gallstone Disease
Mertens, M. C., Roukema, J. A., Scholtes, V. P. W., & Vries, J. D. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181cb65b4 · Cited by 12 · see citing works
Safety and effectiveness of vonoprazan-based rescue therapy for Helicobacter pylori infection
Yu, J., Lv, Y.-M., Yang, P., Jiang, Y., Qin, X., & Wang, X. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i20.3133 · Cited by 11 · see citing works
Fond, G. B., Chevalier, G., Eberl, G., & Leboyer, M. (2015) · La Presse Médicale · doi:10.1016/j.lpm.2015.10.016 · Cited by 11 · see citing works
de Vargas, D., Ramírez, É. G. L., Pereira, C. F., Volpato, R. J., & de Oliveira, S. R. (2022) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-022-00785-2 · Cited by 10 · see citing works
Barazanji, N., Hamilton, J. P., Icenhour, A., Simon, R. A., Bednarska, O., Tapper, S., Tisell, A., Lundberg, P., Engström, M., & Walter, S. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103128 · Cited by 10 · see citing works
Mirijello, A., Ritrovato, N., D’Agruma, A., de Matthaeis, A., Pazienza, L., Parente, P., Cassano, D. P., Biancofiore, A., Ambrosio, A., Carosi, I., et al. (2023) · Medicina · doi:10.3390/medicina59020293 · Cited by 10 · see citing works
Self-citationGravina, A. G., Pellegrino, R., Iascone, V., Palladino, G., Federico, A., & Zagari, R. M. (2024) · Diseases · doi:10.3390/diseases12080179 · Cited by 10 · see citing works
Trait Anxiety Predicts Outcome 6 Weeks After Cholecystectomy. A Prospective Follow-Up Study
Mertens, M. C., Roukema, J. A., Scholtes, V. P. W., & Vries, J. D. (2010) · Annals of Behavioral Medicine · doi:10.1007/s12160-010-9245-x · Cited by 10 · see citing works
The Role of Probiotics in Acne and Rosacea
Porubsky, C. F., Glass, A. B., Comeau, V., Buckley, C. D., Goodman, M. B., & Kober, M.-M. (2018) · InTech eBooks · doi:10.5772/intechopen.79044 · Cited by 10 · see citing works
Tucker, R. M., Ryan, S., Hayee, B., Bjarnason, I., Augustin, A. D., Umamahesan, C., Taylor, D. M., Weller, C., Dobbs, S. M., Dobbs, R. J., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061916 · Cited by 10 · see citing works
Psychotropic medication use among patients with celiac disease
Zylberberg, H. M., Ludvigsson, J. F., Green, P. H. R., & Lebwohl, B. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1668-0 · Cited by 9 · see citing works
Lopresti, A. L., Gupta, H., & Smith, S. J. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2168-y · Cited by 9 · see citing works
Barberio, B., Zamani, M., Black, C. J., Savarino, E. V., & Ford, A. C. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3746277 · Cited by 9 · see citing works
Tang, Q., Wang, R., Niu, H., Li, Y., Li, Y., Hu, Z., Liu, X., & Tao, Y. (2024) · PsyCh Journal · doi:10.1002/pchj.757 · Cited by 8 · see citing works
Ferrarese, D., Vecchione, M., Spagnolo, G., Mirijello, A., Vincenzo, F. D., Belella, D., Camardese, G., D’Onofrio, A. M., Mora, V., Napolitano, D., et al. (2025) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2025.112309 · Cited by 9 · see citing works
Self-citationPersonality traits are related to functional dyspepsia in a large sample of Iranian adults.
Sharbafchi, M., Tabatabaiyan, S., Haghighatdoost, F., Afshar, H., Keshteli, A., Feizi, A., Moghtadaee, K., Roohafza, H., & Adibi, P. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.109912 · Cited by 7 · see citing works
The connection between fatty acids and inflammation in celiac disease; a deep exploring
Bakhtiari, S., Asri, N., Jahdkaran, M., Rezaei–Tavirani, M., Jahani‐Sherafat, S., & Rostami‐Nejad, M. (2024) · Tissue Barriers · doi:10.1080/21688370.2024.2342619 · Cited by 8 · see citing works
Minocha, A., Bollineni, D., Johnson, W. D., & Wigington, W. C. (2010) · Southern Medical Journal · doi:10.1097/smj.0b013e3181e63653 · Cited by 7 · see citing works
The Prevalence of Anxiety and Depressive Symptoms Among Patients With Celiac Disease in Jordan
Ali, S. H., Alqurneh, R., Sneineh, A. T. A., Ghazal, B., Agraib, L. M., Abbasi, L. N., Rifaei, S., & Mazzawi, T. R. E. (2023) · Cureus · doi:10.7759/cureus.39842 · Cited by 8 · see citing works
Li, Y., Shi, L., Yue, L., Gao, R., Yu, Z. Q., Yang, X. H., Liu, L., & Zheng, H. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.03.023 · Cited by 7 · see citing works
Quigley, E. M. M. (2012) · Springer eBooks · doi:10.1007/978-1-4419-1623-5_48 · Cited by 7 · see citing works
Shah, N. N., Schwandt, M. L., Hobden, B., Baldwin, D. S., Sinclair, J., Agabio, R., & Leggio, L. (2021) · Addiction · doi:10.1111/add.15516 · Cited by 6 · see citing works
Self-citationShoji, T., Endo, Y., & Fukudo, S. (2018) · Springer eBooks · doi:10.1007/978-981-13-1074-4_9 · Cited by 6 · see citing works
Beinvogl, B. C., Burch, E., Snyder, J. M., Liu, E., Schechter, N. L., Riley, B. L., Hale, A. E., Brewer, H. J., & Nurko, S. (2025) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.70155 · Cited by 5 · see citing works
Spyridaki, A., Psylinakis, E., Chatzivasili, D., Thalassinos, N., Kounelaki, V., Charonitaki, A., & Markaki, A. G. (2022) · Psychology Health & Medicine · doi:10.1080/13548506.2022.2052329 · Cited by 5 · see citing works
Gut microbes and skin disease, gut-brain-skin axis: A review
Jin, F., & Duan, Y. (2017) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972016-00473 · Cited by 3 · see citing works
Dzirlo, L., Richter, F., Steinmair, D., & Löffler‐Stastka, H. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18052780 · Cited by 5 · see citing works
From gut to skin: the association between celiac disease and cutaneous abnormalities
Abenavoli, L., BENNARDO, L., Nisticò, S. P., & Luzza, F. (2021) · Minerva Gastroenterology · doi:10.23736/s2724-5985.21.02832-4 · Cited by 4 · see citing works
Self-citation
- Authors
- Addolorato, G., Mirijello, A., D’Angelo, C., Leggio, L., Ferrulli, A., Abenavoli, L., Vonghia, L., Cardone, S., Leso, V., Cossari, A., Capristo, E., & Gasbarrini, G.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- University of Calabria (IT)
- ORCID
- Venue
- International Journal of Clinical Practice
- Publisher
- Hindawi Limited
- Published
- 2008-04-18
- Volume
- 62
- Issue
- 7
- Pages
- 1063-1069
- ISSN
- 1368-5031 (ISSN-L)
- OpenAlex
- W1573315265
- Cited by
- 150
- References
- 43
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 12 · 2021: 15 · 2020: 12 · 2019: 6 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 8 · 2014: 10 · 2013: 6 · 2012: 5
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- state anxiety, trait anxiety, depression, gastrointestinal diseases, irritable bowel syndrome, small intestinal bacterial overgrowth, Helicobacter pylori infection, celiac disease, food allergy, ulcerative colitis, sex differences, mood disorders, psychosomatic medicine
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Anxiety Disorders, Depressive Disorder, Female, Gastrointestinal Diseases, Humans, Italy, Male, Middle Aged, Outpatients, Psychiatric Status Rating Scales, Psychometrics, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
