Pharmacological approaches to reducing craving in patients with alcohol use disorders

Haass-Koffler, Carolina L.; Leggio, Lorenzo; Kenna, George A.

doi:10.1007/s40263-014-0149-3

Cited by 83Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorAlcohol Consumption and Health Effects

Pharmacological approaches to reducing craving in patients with alcohol use disorders

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Haass-Koffler, Carolina L., Leggio, Lorenzo, Kenna, George A.·2014·CNS Drugs

DOI 10.1007/s40263-014-0149-3PMC PMC3990000

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Abstract

Research on the concept of craving may lead to better understanding of the biobehavioural circuitries that contribute to the complexity of alcohol use disorders (AUDs). The experiences described as craving or desire to drink are often associated with physical responses such as increased salivation and heart rate, and alteration of stress hormones, as well as psychological responses such as anxiety and depression. Greater craving has been associated with an increased probability of alcohol relapse. Reversal of craving, which is understood as a symptom of protracted abstinence, offers the possibility of preventing relapses and treating alcoholism. Various medications have been studied to establish whether they are able to reduce craving; however, the results obtained from clinical studies have been inconsistent. Here, we review the interdisciplinary models developed to evaluate craving, then the different approaches used to assess and measure craving and, finally, the medications utilized and tested to lessen craving in patients suffering from AUDs.

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Research works printed but not linked: 2

[51]Verheul R van den Brink W Geerlings P A three-pathway psychobiological model of craving for alcohol Alcohol Alcohol Mar-Apr 1999 34 2 197 222 [Review] 10344781
[122]Anton RF Moak DH Waid LR Latham PK Malcolm RJ Dias JK Naltrexone and cognitive behavioral therapy for the treatment of outpatient alcoholics: results of a placebo-controlled trial Am J Psychiatry 11 1999 156 11 1758 64 [Clinical TrialRandomized Controlled TrialResearch Support, U.S. Gov't, P.H.S.] 10553740

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Authors: Haass-Koffler, C. L., Leggio, L., & Kenna, G. A.
Affiliations: National Institutes of Health (US)
Brown University (US)
Corresponding author: Kenna, George A.
ORCID: Leggio, Lorenzo
Venue: CNS Drugs
Publisher: Springer Science and Business Media LLC
Published: 2014-02-27
Volume: 28
Issue: 4
Pages: 343-360
ISSN: 1172-7047 (ISSN-L)
1179-1934
DOI: 10.1007/s40263-014-0149-3
PMC: PMC3990000
OpenAlex: W2078816211
Cited by: 83
References: 270
Citations by year: 2026: 3 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 10 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 7 · 2014: 2
FWCI: 0.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: CNS Drugs (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (R01AA015753, K01AA023867, R03AA020169, R21AA019994, R01AA016079, R21AA021128, R21AA019709, T32AA007459)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: alcohol craving, alcoholism, craving measurement, alcohol relapse prevention, protracted abstinence, stress hormones, anxiety and depression
MeSH terms: Animals, Humans, Serotonin Antagonists, Receptors, N-Methyl-D-Aspartate, Behavior, Addictive, Excitatory Amino Acid Antagonists, Alcohol-Related Disorders, Craving

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Pharmacological approaches to reducing craving in patients with alcohol use disorders

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