Cited by 126Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disordersNeurological Disease Mechanisms and Treatments

Targeting innate immunity for neurodegenerative disorders of the central nervous system

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Andreasson, Katrin I., Bachstetter, Adam D., Colonna, Marco, Ginhoux, Florent, Holmes, Clive, Lamb, Bruce, Landreth, Gary, Lee, Daniel C. +13 more·2016·Journal of Neurochemistry

Abstract

Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7-9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview of physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia and astrocyte cultures. Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article. Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7-9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer's disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview on physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia cultures. Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article.

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  1. Guerreiro R Wojtas A 2013 TREM2 variants in Alzheimer’s disease N Engl J Med 368 2 117 127 23150934 PMC3631573
  2. Johnson VE Stewart JE 2013 Inflammation and white matter degeneration persist for years after a single traumatic brain injury Brain 136 28 42 23365092 PMC3562078
  3. Lee DC Rizer J 2010 LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice J Neuroinflammation 7 56 20846376 PMC2949628
  4. Liang X Wang Q 2008 The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis Ann Neurol 64 3 304 314 18825663 PMC2766522

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Authors
Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, D., Lynch, M. A., Monsonego, A., O'Banion, M. K., Pekny, M., Puschmann, T., Russek‐Blum, N., Sandusky, L. A., Selenica, M. B., Takata, K., Teeling, J., Town, T., & Van Eldik, L. J.
Affiliations
  • Stanford Medicine (US)
  • University of Kentucky (US)
  • Washington University in St. Louis (US)
  • Agency for Science, Technology and Research (SG)
  • University of Southampton (GB)
  • Cleveland Clinic (US)
  • Case Western Reserve University (US)
  • University of South Florida (US)
  • Trinity College Dublin (IE)
  • Ben-Gurion University of the Negev (IL)
  • Departments of Neuroscience and Neurology Del Monte Neuromedicine Institute University of Rochester School of Medicine & Dentistry Rochester NY USA
  • Florey Institute of Neuroscience and Mental Health (AU)
  • University of Gothenburg (SE)
  • Dead Sea and Arava Science Center (IL)
  • Southampton General Hospital (GB)
  • University of Southern California (US)
  • Sanders‐Brown Center on Aging Spinal Cord and Brain Injury Research Center, and Department of Anatomy and Neurobiology University of Kentucky Lexington KY USA
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
2016-08-24
Volume
138
Issue
5
Pages
653-693
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
OpenAlex
W2418940280
Cited by
126
References
403
Citations by year
2026: 2 · 2025: 3 · 2024: 11 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 17 · 2019: 17 · 2018: 15 · 2017: 27 · 2016: 7
FWCI
1.93
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurochemistry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • NOVA (University of Newcastle Australia) (submittedVersion)
Funders
  • National Institutes of Health (R01 NS076794, R21 NS048522, R01 AG30149, R01AG023012, R01NS074804, RF1 AG051485 01, R01AG043522, R01AG030209, R21AG033914, P50 AG047366, R01 NS093920, U01 AG050636, P30 AG028383, K99 AG044445)
  • American Federation for Aging Research (M11472)
  • Cure Alzheimer's Fund
  • Alzheimer's Association
  • Pfizer
  • Wellcome Trust
  • Science Foundation Ireland (11/PI/2014)
  • Higher Education Authority
  • Alzheimer's Drug Discovery Foundation
  • Edward N. and Della L. Thome Memorial Foundation
  • Medicinska Forskningsrådet (11548)
  • Seventh Framework Programme (237956, 279017)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
neuroinflammation, innate immunity, neurodegenerative diseases, microglia, astrocytes, traumatic brain injury, Alzheimer's disease, PGE2 receptors, arginine metabolism, induced pluripotent stem cell-derived microglia, TREM2 signaling, microglial morphology
MeSH terms
Animals, Astrocytes, Central Nervous System, Humans, Immunity, Innate, Inflammation, Microglia, Neurodegenerative Diseases

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