Neuroinflammatory changes negatively impact on LTP: A focus on IL-1β

Lynch, Marina A

doi:10.1016/j.brainres.2014.08.040

Cited by 115Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Neuroinflammatory changes negatively impact on LTP: A focus on IL-1β

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Lynch, Marina A·2015·Brain Research

DOI 10.1016/j.brainres.2014.08.040

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Abstract

In recent years it has become clear that neuroinflammatory changes develop in the brain with age and that similar, though more profound changes, occur in neurodegenerative conditions and in animal models of neurodegeneration. These changes are linked with deterioration in plasticity and the evidence suggests that a key causative factor is microglial activation and the associated increase in production and release of inflammatory cytokines. Several groups have reported that interleukin (IL)-1β negatively impacts on hippocampal-dependent learning and has an inhibitory effect on LTP although this is concentration-dependent. Similarly other inflammatory cytokines, which are also produced by microglia similarly decrease LTP. The evidence supporting these findings will be reviewed here and will be discussed in the context of considering mechanisms by which the negative impact of neuroinflammation can be ameliorated. This article is part of a Special Issue entitled SI: Brain and Memory.

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Pro-inflammatory cytokines, especially IL-1β, can downregulate BDNF expression in cognition-related brain structures such as the hippocampus.
“pro-inflammatory cytokines—especially IL-1β—can cause downregulation of BDNF expression in cognition-related brain structures, such as the hippocampus [157, 158].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [157]

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Authors: Lynch, M. A.
Affiliations: Trinity College Dublin (IE)
Corresponding author: Lynch, Marina A
ORCID: Lynch, Marina A
Venue: Brain Research
Publisher: Elsevier BV
Published: 2015-09
Volume: 1621
Pages: 197-204
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2014.08.040
OpenAlex: W2066870378
Cited by: 115
References: 105
Citations by year: 2026: 10 · 2025: 6 · 2024: 13 · 2023: 10 · 2022: 11 · 2021: 13 · 2020: 9 · 2019: 7 · 2018: 11 · 2017: 12 · 2016: 6 · 2015: 5 · 2014: 2
FWCI: 0.67
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (submittedVersion)
Funders: Science Foundation Ireland (11/PI/1014)
The Higher Education Authority (PRTLI)
The Health Research Board Ireland (PHD/2007/13)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: neuroinflammation, long-term potentiation, IL-1β, microglial activation, inflammatory cytokines, hippocampus-dependent learning, synaptic plasticity, neurodegeneration
MeSH terms: Animals, Encephalitis, Hippocampus, Humans, Microglia, Long-Term Potentiation, Interleukin-1beta

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Neuroinflammatory changes negatively impact on LTP: A focus on IL-1β

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