Kathiresan, Sekar

Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism

Strong, A., Ding, Q., Edmondson, A. C., Millar, J. S., Sachs, K. V., Li, X., Kumaravel, A., Wang, M. Y., Ai, D., Guo, L., et al. (2012) · Journal of Clinical Investigation

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 222

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

the CARDIoGRAM Consortium, Bis, J. C., Kavousi, M., Franceschini, N., Isaacs, A., Abecasis, G. R., Schminke, U., Post, W. S., Smith, A. V., Cupples, L. A., et al. (2011) · Nature Genetics

Genetic Associations and EpidemiologyCardiovascular Health and Disease Prevention

Cited by 212

Association of rare and common variation in the lipoprotein lipase gene with coronary artery disease

Khera, A. V., Won, H.-H., Peloso, G. M., O’Dushlaine, C., Liu, D., Stitziel, N. O., Natarajan, P., Nomura, A., Emdin, C. A., Gupta, N., et al. (2017) · JAMA

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 198

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease

van Meurs, J. B., Pare, G., Schwartz, S. M., Hazra, A., Tanaka, T., Vermeulen, S. H., Cotlarciuc, I., Yuan, X., Mälarstig, A., Bandinelli, S., et al. (2013) · The American Journal of Clinical Nutrition

Folate and B Vitamins ResearchGenetic Associations and Epidemiology

Cited by 198

Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

Mäkinen, V.-P., Civelek, M., Meng, Q., Zhang, B., Zhu, J., Levian, C., Huan, T., Segrè, A. V., Ghosh, S., Vivar, J., et al. (2014) · PLoS Genetics

Bioinformatics and Genomic NetworksGenetic Associations and Epidemiology

Cited by 196

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease

Warren, C. R., O’Sullivan, J. F., Friesen, M., Becker, C. E., Zhang, X., Liu, P., Wakabayashi, Y., Morningstar, J. E., Shi, X., Choi, J., et al. (2017) · Cell stem cell

Pluripotent Stem Cells ResearchGenetic Associations and Epidemiology

Cited by 191

A PCSK9 Missense Variant Associated with a Reduced Risk of Early-Onset Myocardial Infarction

Kathiresan, S. (2008) · New England Journal of Medicine

Genetic Associations and EpidemiologyLipoproteins and Cardiovascular Health

Cited by 183

Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk.

Musunuru, K., Orho-Melander, M., Caulfield, M. P., Li, S., Salameh, W. A., Reitz, R. E., Berglund, G., Hedblad, B., Engström, G., Williams, P. T., et al. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology

Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 168

Surprises from genetic analyses of lipid risk factors for atherosclerosis

Musunuru, K., & Kathiresan, S. (2016) · Circulation Research

Lipoproteins and Cardiovascular HealthLipid metabolism and disorders

Cited by 159

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

Voight, B. F., Peloso, G. M., Orho-Melander, M., Frikke-Schmidt, R., Barbalic, M., Jensen, M. K., Hindy, G., Hólm, H., Ding, E. L., Johnson, T., et al. (2012) · The Lancet

Genetic Associations and EpidemiologyLipoproteins and Cardiovascular Health

Cited by 148

Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese

Lubitz, S. A., Lunetta, K. L., Lin, H., Arking, D. E., Trompet, S., Li, G., Krijthe, B. P., Chasman, D. I., Barnard, J., Kleber, M. E., et al. (2014) · Journal of the American College of Cardiology

Atrial Fibrillation Management and OutcomesGenetic Associations and Epidemiology

Cited by 148

Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes

Flannick, J., Beer, N. L., Bick, A. G., Agarwala, V., Molnes, J., Gupta, N., Burtt, N. P., Florez, J. C., Meigs, J. B., Taylor, H., et al. (2013) · Nature Genetics

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 136

Description of a Large Family with Autosomal Dominant Hypercholesterolemia Associated with the APOE p.Leu167del Mutation

Marduel, M., Ouguerram, K., Serre, V., Bonnefont-Rousselot, D., Marques-Pinheiro, A., Erik Berge, K., Devillers, M., Luc, G., Lecerf, J.-M., Tosolini, L., et al. (2013) · Human Mutation

Lipoproteins and Cardiovascular HealthLipid metabolism and disorders

Cited by 133

Associations of Long-Term and Early Adult Atherosclerosis Risk Factors With Aortic and Mitral Valve Calcium

Thanassoulis, G., Massaro, J. M., Cury, R., Manders, E., Benjamin, E. J., Vasan, R. S., Cupple, L. A., Hoffmann, U., O'Donnell, C. J., & Kathiresan, S. (2010) · Journal of the American College of Cardiology

Cardiac Valve Diseases and TreatmentsCardiac Imaging and Diagnostics

Cited by 114

GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis

Yu, H., Rimbert, A., Palmer, A. E., Toyohara, T., Xia, Y., Xia, F., Ferreira, L. M. R., Chen, Z., Chen, T., Loaiza, N., et al. (2019) · Cell

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 113

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

Ganna, A., Satterstrom, F. K., Zekavat, S. M., Das, I., Kurki, M. I., Churchhouse, C., Alfoldi, J., Martin, A. R., Havulinna, A. S., Byrnes, A., et al. (2018) · The American Journal of Human Genetics

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 110

Twelve-single nucleotide polymorphism genetic risk score identifies individuals at increased risk for future atrial fibrillation and stroke

Tada, H., Shiffman, D., Smith, J. G., Sjögren, M., Lubitz, S. A., Ellinor, P. T., Louie, J. Z., Catanese, J. J., Engström, G., Devlin, J. J., et al. (2014) · Stroke

Atrial Fibrillation Management and OutcomesGenetic Associations and Epidemiology

Cited by 110

Clinical characteristics and plasma lipids in subjects with familial combined hypolipidemia: a pooled analysis

Minicocci, I., Santini, S., Cantisani, V., Stitziel, N., Kathiresan, S., Arroyo, J. A., Martí, G., Pisciotta, L., Noto, D., Cefalù, A. B., et al. (2013) · Journal of Lipid Research

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 97

An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia

Johansen, C. T., Wang, J., Lanktree, M. B., McIntyre, A. D., Ban, M. R., Martins, R. A., Kennedy, B. A., Hassell, R. G., Visser, M. E., Schwartz, S. M., et al. (2011) · Arteriosclerosis, Thrombosis, and Vascular Biology

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 97

Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction

The Myocardial Infarction Genetics Consortium, Shea, J., Agarwala, V., Philippakis, A. A., Maguire, J., Banks, E., DePristo, M., Thomson, B., Guiducci, C., Onofrio, R. C., et al. (2011) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 87

Influence of 9p21.3 Genetic Variants on Clinical and Angiographic Outcomes in Early-Onset Myocardial Infarction

Ardissino, D., Berzuini, C., Merlini, P. A., Mannuccio Mannucci, P., Surti, A., Burtt, N., Voight, B., Tubaro, M., Peyvandi, F., Spreafico, M., et al. (2011) · Journal of the American College of Cardiology

Genetic Associations and EpidemiologyAcute Myocardial Infarction Research

Cited by 80

Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis

Natarajan, P., Bis, J. C., Bielak, L. F., Cox, A. J., Dörr, M., Feitosa, M. F., Franceschini, N., Guo, X., Hwang, S.-J., Isaacs, A., et al. (2016) · Circulation: Cardiovascular Genetics

Genetic Associations and EpidemiologyAtherosclerosis and Cardiovascular Diseases

Cited by 66

Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis

Natarajan, P., Jaiswal, S., & Kathiresan, S. (2018) · Circulation Genomic and Precision Medicine

Acute Myeloid Leukemia ResearchAtherosclerosis and Cardiovascular Diseases

Cited by 63

Phenotypic extremes in rare variant study designs

Peloso, G. M., Rader, D. J., Gabriel, S., Kathiresan, S., Daly, M. J., & Neale, B. M. (2016) · European Journal of Human Genetics

Genetic Associations and EpidemiologyGenomics and Rare Diseases

Cited by 58