Spitz, Douglas R.

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

Erickson, J. R., Joiner, M.-L. A., Guan, X., Kutschke, W., Yang, J., Oddis, C. V., Bartlett, R. K., Lowe, J. S., O'Donnell, S. E., Aykin-Burns, N., et al. (2008) · Cell

Redox biology and oxidative stressCardiac electrophysiology and arrhythmias

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Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress

Tao, R., Coleman, M. C., Pennington, J. D., Ozden, O., Park, S.-H., Jiang, H., Kim, H.-S., Flynn, C. R., Hill, S., Hayes McDonald, W., et al. (2010) · Molecular Cell

Sirtuins and Resveratrol in MedicineRedox biology and oxidative stress

Cited by 899

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

Kim, H.-S., Patel, K., Muldoon-Jacobs, K., Bisht, K. S., Aykin-Burns, N., Pennington, J. D., van der Meer, R., Nguyen, P., Savage, J., Owens, K. M., et al. (2010) · Cancer Cell

Sirtuins and Resveratrol in MedicineMitochondrial Function and Pathology

Cited by 785

Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology

Spitz, D. R., Azzam, E. I., Jian Li, J., & Gius, D. (2004) · Cancer and Metastasis Reviews

Effects of Radiation ExposureRedox biology and oxidative stress

Cited by 710

O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., et al. (2017) · Cancer Cell

Vitamin C and Antioxidants ResearchCancer, Hypoxia, and Metabolism

Cited by 443

DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway

Kang, M. A., So, E.-Y., Simons, A. L., Spitz, D. R., & Ouchi, T. (2012) · Cell Death & Disease

Redox biology and oxidative stressDNA Repair Mechanisms

Cited by 311

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer

Du, J., Cieslak, J. A., Welsh, J. L., Sibenaller, Z. A., Allen, B. G., Wagner, B. A., Kalen, A. L., Doskey, C. M., Strother, R. K., Button, A. M., et al. (2015) · Cancer Research

Vitamin C and Antioxidants ResearchEffects of Radiation Exposure

Cited by 112

Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism

Sobhakumari, A., Love-Homan, L., Fletcher, E. V. M., Martin, S. M., Parsons, A. D., Spitz, D. R., Knudson, C. M., & Simons, A. L. (2012) · PLoS ONE

Redox biology and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 80

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

Tompkins, S. C., Sheldon, R. D., Rauckhorst, A. J., Noterman, M. F., Solst, S. R., Buchanan, J. L., Mapuskar, K. A., Pewa, A. D., Gray, L. R., Oonthonpan, L., et al. (2019) · Cell Reports

Cancer, Hypoxia, and MetabolismSulfur Compounds in Biology

Cited by 79

Cigarette Smoke Induces Cellular Senescence via Werner's Syndrome Protein Down-regulation

Nyunoya, T., Monick, M. M., Klingelhutz, A. L., Glaser, H., Cagley, J. R., Brown, C. O., Matsumoto, E., Aykin-Burns, N., Spitz, D. R., Oshima, J., et al. (2009) · American Journal of Respiratory and Critical Care Medicine

Telomeres, Telomerase, and SenescenceSmoking Behavior and Cessation

Cited by 79

Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide

Sishc, B. J., Ding, L., Nam, T.-K., Heer, C. D., Rodman, S. N., Schoenfeld, J. D., Fath, M. A., Saha, D., Pulliam, C. F., Langen, B., et al. (2021) · Science Translational Medicine

Redox biology and oxidative stressEffects of Radiation Exposure

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