Portal fibroblasts: Underappreciated mediators of biliary fibrosis†
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UNLABELLED: Portal fibroblasts are an important yet often overlooked nonparenchymal cell population in the liver. They are distinct from hepatic stellate cells, yet like stellate cells differentiate in the setting of chronic injury to fibrogenic myofibroblasts, playing an important role in collagen production in the fibrotic liver. Portal fibroblasts (PFs) are located adjacent to bile duct epithelia and thus play a particularly significant role in biliary fibrosis. New data suggest that they may also have key functions independent of fibrogenesis. This review addresses the definition and characteristics of PFs as well as their signaling pathways, interactions with the biliary epithelium, and contributions to liver pathobiology. CONCLUSION: PFs are an important and multifunctional nonparenchymal cell population in need of further study.
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PFs are a key myofibroblast precursor in cholestatic liver injury, and PF populations expand in murine models of biliary injury, expressing high levels of fibrillar collagen at single-cell resolution.
“PFs are a key myofibroblast precursor in cholestatic liver injury,133 and populations of PFs have been shown to expand in murine models of biliary injury, expressing high levels of fibrillar collagen at single-cell resolution.134”
From Understanding the cellular interactome of non-alcoholic fatty liver disease (2022) · cites this paper as [133]
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- Authors
- Dranoff, J. A., & Wells, R. G.
- Affiliations
- Yale University (US)
- University of Pennsylvania (US)
- Corresponding author
- Dranoff, Jonathan A.
- Venue
- Hepatology
- Published
- 2010-04
- Volume
- 51
- Issue
- 4
- Pages
- 1438-1444
- ISSN
- 0270-9139 (ISSN-L)
- PMC
- PMC2850946
- OpenAlex
- W2012962601
- Cited by
- 273
- References
- 72
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 12 · 2023: 15 · 2022: 19 · 2021: 13 · 2020: 17 · 2019: 10 · 2018: 14 · 2017: 16 · 2016: 18 · 2015: 21 · 2014: 24 · 2013: 20 · 2012: 26
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Yale University
- National Institutes of Health (DK34989)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK070849, DK-34989, R01DK058123, R01-DK58123, P30DK034989)
- Yale Liver Center (DK34989)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- portal fibroblasts, liver fibrosis, biliary fibrosis, non-parenchymal liver cells, hepatic stellate cells, myofibroblasts, collagen synthesis, bile duct epithelium, signaling pathways
- MeSH terms
- Animals, Cell Communication, Cell Differentiation, Fibroblasts, Humans, Liver Cirrhosis, Biliary, Portal System, Signal Transduction
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