Sobue, Gen

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

Fujimori, K., Ishikawa, M., Otomo, A., Atsuta, N., Nakamura, R., Akiyama, T., Hadano, S., Aoki, M., Saya, H., Sobue, G., et al. (2018) · Nature Medicine

Amyotrophic Lateral Sclerosis ResearchPluripotent Stem Cells Research

Cited by 494

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

Waza, M., Adachi, H., Katsuno, M., Minamiyama, M., Sang, C., Tanaka, F., Inukai, A., Doyu, M., & Sobue, G. (2005) · Nature Medicine

Genetic Neurodegenerative DiseasesHeat shock proteins research

Cited by 395

Exosome secretion is a key pathway for clearance of pathological TDP-43

Iguchi, Y., Eid, L., Parent, M., Soucy, G., Bareil, C., Riku, Y., Kawai, K., Takagi, S., Yoshida, M., Katsuno, M., et al. (2016) · Brain

Amyotrophic Lateral Sclerosis ResearchExtracellular vesicles in disease

Cited by 360

Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis

Jiang, Y., Yamamoto, M., Kobayashi, Y., Yoshihara, T., Liang, Y., Terao, S., Takeuchi, H., Ishigaki, S., Katsuno, M., Adachi, H., et al. (2005) · Annals of Neurology

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 255

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells

Endo, F., Komine, O., Fujimori-Tonou, N., Katsuno, M., Jin, S., Watanabe, S., Sobue, G., Dezawa, M., Wyss-Coray, T., & Yamanaka, K. (2015) · Cell Reports

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 207

HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease

Fujita, K., Motoki, K., Tagawa, K., Chen, X., Hama, H., Nakajima, K., Homma, H., Tamura, T., Watanabe, H., Katsuno, M., et al. (2016) · Scientific Reports

Alzheimer's disease research and treatmentsAdvanced Glycation End Products research

Cited by 160

Immunohistochemical Localization of Advanced Glycation End Products, Pentosidine, and Carboxymethyllysine in Lipofuscin Pigments of Alzheimer's Disease and Aged Neurons

Horie, K., Miyata, T., Yasuda, T., Takeda, A., Yasuda, Y., Maeda, K., Sobue, G., & Kurokawa, K. (1997) · Biochemical and Biophysical Research Communications

Advanced Glycation End Products researchAlzheimer's disease research and treatments

Cited by 137

YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology

Tanaka, H., Homma, H., Fujita, K., Kondo, K., Yamada, S., Jin, X., Waragai, M., Ohtomo, G., Iwata, A., Tagawa, K., et al. (2020) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 119

Involvement of the precuneus/posterior cingulate cortex is significant for the development of Alzheimer’s disease: a pet (THK5351, PiB) and resting fMRI study.

Yokoi, T., Watanabe, H., Yamaguchi, H., Bagarinao, E., Masuda, M., Imai, K., Ogura, A., Ohdake, R., Kawabata, K., Hara, K., et al. (2018) · Frontiers in Aging Neuroscience

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 116

Reorganization of brain networks and its association with general cognitive performance over the adult lifespan

Bagarinao, E., Watanabe, H., Maesawa, S., Mori, D., Hara, K., Kawabata, K., Yoneyama, N., Ohdake, R., Imai, K., Masuda, M., et al. (2019) · Scientific Reports

Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and Applications

Cited by 108

Paraneoplastic neuropathy: wide-ranging clinicopathological manifestations

Koike, H., Tanaka, F., & Sobue, G. (2011) · Current Opinion in Neurology

Autoimmune Neurological Disorders and TreatmentsPeripheral Neuropathies and Disorders

Cited by 105

Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells

Picher-Martel, V., Dutta, K., Phaneuf, D., Sobue, G., & Julien, J.-P. (2015) · Molecular Brain

Amyotrophic Lateral Sclerosis ResearchNF-κB Signaling Pathways

Cited by 65

Phenotypic heterogeneity of an adult form of adrenoleukodystrophy in monozygotic twins

Sobue, G., Ueno‐Natsukari, I., Okamoto, H., Connell, T. A., Aizawa, I., Mizoguchi, K., Honma, M., Ishikawa, G., Mitsuma, T., & Natsukari, N. (1994) · Annals of Neurology

Metabolism and Genetic DisordersHereditary Neurological Disorders

Cited by 56

Altered GluA1 (Gria1) Function and Accumbal Synaptic Plasticity in the ClockΔ19 Model of Bipolar Mania

Parekh, P. K., Becker-Krail, D., Sundaravelu, P., Ishigaki, S., Okado, H., Sobue, G., Huang, Y., & McClung, C. A. (2018) · Biological Psychiatry

Neuroscience and Neuropharmacology ResearchCircadian rhythm and melatonin

Cited by 48

Characteristics of Neural Network Changes in Normal Aging and Early Dementia

Watanabe, H., Bagarinao, E., Maesawa, S., Hara, K., Kawabata, K., Ogura, A., Ohdake, R., Shima, S., Mizutani, Y., Ueda, A., et al. (2021) · Frontiers in Aging Neuroscience

Functional Brain Connectivity StudiesDementia and Cognitive Impairment Research

Cited by 48

FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD

Fujioka, Y., Ishigaki, S., Masuda, A., Iguchi, Y., Udagawa, T., Watanabe, H., Katsuno, M., Ohno, K., & Sobue, G. (2013) · Scientific Reports

Amyotrophic Lateral Sclerosis ResearchRNA Research and Splicing

Cited by 46

Tremor is attenuated during walking in essential tremor with resting tremor but not parkinsonian tremor

Uchida, K., Hirayama, M., Yamashita, F., Hori, N., Nakamura, T., & Sobue, G. (2011) · Journal of Clinical Neuroscience

Deep Brain Stimulation and Movement DisordersParkinson's Disease Mechanisms and Treatments

Cited by 32

Treatment with Creatine Monohydrate in Spinal and Bulbar Muscular Atrophy: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial

Hijikata, Y., Katsuno, M., Suzuki, K., Hashizume, A., Araki, A., Yamada, S., Inagaki, T., Ito, D., Hirakawa, A., Kinoshita, F., et al. (2018) · JMIR Research Protocols

Genetic Neurodegenerative DiseasesAmyotrophic Lateral Sclerosis Research

Cited by 13

Stress-impaired reward pathway promotes distinct feeding behavior patterns

Fujioka, Y., Kawai, K., Endo, K., Ishibashi, M., Iwade, N., Tuerde, D., Kaibuchi, K., Yamashita, T., Yamanaka, A., Katsuno, M., et al. (2024) · Frontiers in Neuroscience

Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and Obesity

Cited by 6

Stress-impaired reward pathway promotes distinct feeding behavior patterns

Fujioka, Y., Kawai, K., Endo, K., Ishibashi, M., Iwade, N., Tuerde, D., Kaibuchi, K., Yamashita, T., Yamanaka, A., Katsuno, M., et al. (2021) · Frontiers in Neuroscience

Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and Obesity

Cited by 6