Exosome secretion is a key pathway for clearance of pathological TDP-43
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mutant. Thus, even though results suggest that exosomes containing pathological TDP-43 may play a key role in the propagation of TDP-43 proteinopathy, a therapeutic strategy for amyotrophic lateral sclerosis based on inhibition of exosome production would seem inappropriate, as in vivo data suggest that exosome secretion plays an overall beneficial role in neuronal clearance of pathological TDP-43.
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TDP-43 protein can be secreted into the extracellular matrix via exosomes or cell death.
“TDP-43 protein could be secreted into the extracellular matrix via exosomes350 or cell death.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [350]
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- Authors
- Iguchi, Y., Eid, L., Parent, M., Soucy, G., Bareil, C., Riku, Y., Kawai, K., Takagi, S., Yoshida, M., Katsuno, M., Sobue, G., & Julien, J.-P.
- Affiliations
- Institut Universitaire en Santé Mentale de Québec (CA)
- Nagoya University (JP)
- Aichi Medical University (JP)
- Corresponding author
- Julien, Jean-Pierre
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-09-27
- Volume
- 139
- Issue
- 12
- Pages
- 3187-3201
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC5840881
- OpenAlex
- W2524787240
- Cited by
- 360
- References
- 6
- Citations by year
- 2026: 24 · 2025: 46 · 2024: 43 · 2023: 35 · 2022: 38 · 2021: 56 · 2020: 52 · 2019: 23 · 2018: 26 · 2017: 16 · 2016: 1
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Japan Society for the Promotion of Science (26461269, 26293206, 16K15480, 26117002, 26117001)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- exosome secretion, TDP-43, amyotrophic lateral sclerosis
- MeSH terms
- Aniline Compounds, Animals, Behavior, Animal, Benzylidene Compounds, Cell Line, Disease Models, Animal, DNA-Binding Proteins, Humans, Mice, Transgenic, Sphingomyelin Phosphodiesterase, Mice, Exosomes, TDP-43 Proteinopathies
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