Jadhav, Vasant

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

Foster, D. J., Brown, C. R., Shaikh, S., Trapp, C., Schlegel, M. K., Qian, K., Sehgal, A., Rajeev, K. G., Jadhav, V., Manoharan, M., et al. (2018) · Molecular Therapy

RNA Interference and Gene DeliveryDNA and Nucleic Acid Chemistry

Cited by 325

Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates

Brown, C. R., Gupta, S., Qin, J., Racie, T., He, G., Lentini, S., Malone, R., Yu, M., Matsuda, S., Shulga-Morskaya, S., et al. (2020) · Nucleic Acids Research

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 285

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

Janas, M. M., Schlegel, M. K., Harbison, C. E., Yilmaz, V. O., Jiang, Y., Parmar, R., Zlatev, I., Castoreno, A., Xu, H., Shulga-Morskaya, S., et al. (2018) · Nature Communications

RNA Interference and Gene DeliveryDrug-Induced Hepatotoxicity and Protection

Cited by 279

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

Nair, J. K., Attarwala, H., Sehgal, A., Wang, Q., Aluri, K., Zhang, X., Gao, M., Liu, J., Indrakanti, R., Schofield, S., et al. (2017) · Nucleic Acids Research

RNA Interference and Gene DeliveryDNA and Nucleic Acid Chemistry

Cited by 278

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Brown, K. M., Nair, J. K., Janas, M. M., Anglero-Rodriguez, Y. I., Dang, L. T. H., Peng, H., Theile, C. S., Castellanos-Rizaldos, E., Brown, C., Foster, D., et al. (2022) · Nature Biotechnology

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 258

Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment

Abrams, M. T., Koser, M. L., Seitzer, J., Williams, S. C., DiPietro, M. A., Wang, W., Shaw, A. W., Mao, X., Jadhav, V., Davide, J. P., et al. (2010) · Molecular Therapy

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 209

Coenzymes as coribozymes

Jadhav, V. R., & Yarus, M. (2002) · Biochimie

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 73

Zeptomole detection of a viral nucleic acid using a target-activated ribozyme

VAISH, N. K., JADHAV, V. R., KOSSEN, K., PASKO, C., ANDREWS, L. E., MCSWIGGEN, J. A., POLISKY, B., & SEIWERT, S. D. (2003) · RNA

RNA and protein synthesis mechanismsAdvanced biosensing and bioanalysis techniques

Cited by 30

Computational Design and Experimental Characterization of Peptides Intended for pH-Dependent Membrane Insertion and Pore Formation

Zhang, Y., Bartz, R., Grigoryan, G., Bryant, M., Aaronson, J., Beck, S., Innocent, N., Klein, L., Procopio, W., Tucker, T., et al. (2015) · ACS Chemical Biology

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 23