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Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides

Moss, K. H., Popova, P. G., Hadrup, S. R., Astakhova, K., & Taskova, M. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01290 · Cited by 99 · see citing works

Messenger RNA-Based Vaccines Against Infectious Diseases

Alameh, M.-G., Weissman, D., & Pardi, N. (2020) · Current Topics in Microbiology and Immunology · doi:10.1007/82_2020_202 · Cited by 96 · see citing works

Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles

Crawford, R., Dogdas, B., Keough, E., Haas, R. M., Wepukhulu, W., Krotzer, S., Burke, P. A., Sepp‐Lorenzino, L., Bagchi, A., & Howell, B. J. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.10.025 · Cited by 96 · see citing works

Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets

Conway, A., Mendel, M., Kim, K., McGovern, K., Boyko, A., Zhang, L., Miller, J. C., DeKelver, R. C., Paschon, D. E., Mui, B. L., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.03.003 · Cited by 95 · see citing works

Ionization Behavior of Amino Lipids for siRNA Delivery: Determination of Ionization Constants, SAR, and the Impact of Lipid pKa on Cationic Lipid−Biomembrane Interactions

Zhang, J., Fan, H., Levorse, D. A., & Crocker, L. S. (2011) · Langmuir · doi:10.1021/la104590k · Cited by 95 · see citing works

Biomimetic noncationic lipid nanoparticles for mRNA delivery

Wang, C., Zhao, C., Wang, W., Liu, X., & Deng, H. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2311276120 · Cited by 91 · see citing works

Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein

Davies, N. M., Hovdal, D., Edmunds, N. J., Nordberg, P., Dahlén, A., Dabkowska, A. P., Arteta, M. Y., Rădulescu, A., Kjellman, T., Höijer, A., et al. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.03.008 · Cited by 88 · see citing works

siRNA Functionalized Lipid Nanoparticles (LNPs) in Management of Diseases

Kalita, T., Dezfouli, S. A., Pandey, L. M., & Uludağ, H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112520 · Cited by 87 · see citing works

Quantitative evaluation of siRNA delivery in vivo

Pei, Y., Hancock, P. J., Zhang, H., Bartz, R., Cherrin, C., Innocent, N., Pomerantz, C. J., Seitzer, J. L., Koser, M. L., Abrams, M. T., et al. (2010) · RNA · doi:10.1261/rna.2255810 · Cited by 82 · see citing works

Rational design of anti‐inflammatory lipid nanoparticles for mRNA delivery

Zhang, H., Han, X., Alameh, M., Shepherd, S. J., Padilla, M. S., Xue, L., Butowska, K., Weissman, D., & Mitchell, M. J. (2022) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37356 · Cited by 82 · see citing works

Effect of Lipid Nanoparticle Physico-Chemical Properties and Composition on Their Interaction with the Immune System

Catenacci, L., Rossi, R., Sechi, F., Buonocore, D., Sorrenti, M., Perteghella, S., Peviani, M., & Bonferoni, M. C. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16121521 · Cited by 83 · see citing works

Unraveling the web of defense: the crucial role of polysaccharides in immunity

Shen, Y., Zhao, H., Wang, X., Wu, S., Wang, Y., Wang, C., Zhang, Y., & Zhao, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1406213 · Cited by 75 · see citing works

Nucleobase and Ribose Modifications Control Immunostimulation by a MicroRNA-122-mimetic RNA

Peacock, H., Fucini, R. V., Jayalath, P., Ibarra‐Soza, J. M., Haringsma, H. J., Flanagan, W. M., Willingham, A. T., & Beal, P. A. (2011) · Journal of the American Chemical Society · doi:10.1021/ja202492e · Cited by 75 · see citing works

siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids

Tadin‐Strapps, M., Peterson, L. B., Cumiskey, A.-M., Rosa, R. L., Mendoza, V., Castro‐Perez, J. M., Puig, Ó., Zhang, L., Strapps, W. R., Yendluri, S., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m012872 · Cited by 75 · see citing works

Nanotechnology for the Detection and Therapy of Stroke

Kyle, S., & Saha, S. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201400009 · Cited by 74 · see citing works

Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses

Tao, W., Mao, X., Davide, J. P., Ng, B., Cai, M., Burke, P. A., Sachs, A. B., & Sepp‐Lorenzino, L. (2010) · Molecular Therapy · doi:10.1038/mt.2010.282 · Cited by 73 · see citing works

Insight into Mechanisms of Cellular Uptake of Lipid Nanoparticles and Intracellular Release of Small RNAs

Yu, B., Wang, X., Zhou, C., Teng, L., Ren, W., Yang, Z., Shih, C., Wang, T., Lee, R. J., Tang, S.-Q., et al. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1366-7 · Cited by 72 · see citing works

Nanoparticle delivery systems for siRNA-based therapeutics

Li, J., Xue, S., & Mao, Z. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb01462c · Cited by 72 · see citing works

Frequency and Associations of Adverse Reactions of COVID-19 Vaccines Reported to Pharmacovigilance Systems in the European Union and the United States

Montano, D. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2021.756633 · Cited by 70 · see citing works

Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering

Monteiro, N. O., Martins, A. M., Reis, R. L., & Neves, N. M. (2015) · Regenerative Therapy · doi:10.1016/j.reth.2015.05.004 · Cited by 70 · see citing works

Mechanism of Macromolecular Structure Evolution in Self-Assembled Lipid Nanoparticles for siRNA Delivery

Gindy, M. E., DiFelice, K., Kumar, V., Prud’homme, R. K., Celano, R., Haas, R. M., Smith, J. S., & Boardman, D. (2014) · Langmuir · doi:10.1021/la500630h · Cited by 69 · see citing works

Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids

Chen, S., Zaifman, J., Kulkarni, J. A., Zhigaltsev, I. V., Tam, Y. K., Ciufolini, M. A., Tam, Y. Y. C., & Cullis, P. R. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.07.026 · Cited by 68 · see citing works

A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics

Ranjbar, S., Zhong, X., Manautou, J. E., & Lü, X. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115052 · Cited by 69 · see citing works

Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape

Bartz, R., Fan, H., Zhang, J., Innocent, N., Cherrin, C., Beck, S. C., Pei, Y., Momose, A., Jadhav, V., Tellers, D. M., et al. (2011) · Biochemical Journal · doi:10.1042/bj20101021 · Cited by 63 · see citing works

Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin

Ganesh, S., Koser, M. L., Cyr, W. A., Chopda, G. R., Tao, J., Shui, X., Ying, B., Chen, D., Pandya, P., Chipumuro, E., et al. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0309 · Cited by 61 · see citing works

Medicinal Chemistry of siRNA Delivery

Stanton, M. G., & Colletti, S. L. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm1003914 · Cited by 60 · see citing works

Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro

Broering, R., Real, C. I., John, M., Jahn‐Hofmann, K., Ickenstein, L. M., Kleinehr, K., Paul, A., Sutter, K., Dittmer, U., Gerken, G., et al. (2013) · International Immunology · doi:10.1093/intimm/dxt040 · Cited by 60 · see citing works

Therapeutic Potential of Nanocarrier-Mediated Delivery of Phytoconstituents for Wound Healing: Their Current Status and Future Perspective

Kumar, M., Keshwania, P., Chopra, S., Mahmood, S., & Bhatia, A. (2023) · AAPS PharmSciTech · doi:10.1208/s12249-023-02616-6 · Cited by 58 · see citing works

Pharmacokinetic Behaviors of Intravenously Administered siRNA in Glandular Tissues

Huang, Y., Cheng, Q., Ji, J.-L., Zheng, S., Du, L., Meng, L., Wu, Y., Zhao, D., Wang, X., Lai, L. F., et al. (2016) · Theranostics · doi:10.7150/thno.15246 · Cited by 59 · see citing works

Delivery and Biodistribution of siRNA for Cancer Therapy: Challenges and Future Prospects

Seth, S., Johns, R. E., & Templin, M. V. (2012) · Therapeutic Delivery · doi:10.4155/tde.11.155 · Cited by 58 · see citing works

Noninvasive Imaging of Lipid Nanoparticle–Mediated Systemic Delivery of Small-Interfering RNA to the Liver

Tao, W., Davide, J. P., Cai, M., Zhang, G., South, V. J., Matter, A. M., Ng, B., Zhang, Y., & Sepp‐Lorenzino, L. (2010) · Molecular Therapy · doi:10.1038/mt.2010.147 · Cited by 57 · see citing works

mRNA vaccines contribute to innate and adaptive immunity to enhance immune response in vivo

Cao, Q., Fang, H., & Tian, H. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122628 · Cited by 55 · see citing works

siRNA Delivery with Lipid-based Systems: Promises and Pitfalls

Foged, C. (2012) · Current Topics in Medicinal Chemistry · doi:10.2174/156802612798919141 · Cited by 54 · see citing works

A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis

Mi, Y., Mu, C., Wolfram, J., Deng, Z., Hu, Y., Liu, X., Blanco, E., Shen, H., & Mauro Ferrari, B. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201500910 · Cited by 53 · see citing works

Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery

Sanchez, A. J. D. S., Zhao, K., Huayamares, S. G., Hatit, M. Z. C., Lokugamage, M. P., Loughrey, D., Dobrowolski, C. N., Wang, S., Kim, H., Paunovska, K., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.11.037 · Cited by 52 · see citing works

Antibody targeting facilitates effective intratumoral siRNA nanoparticle delivery to HER2-overexpressing cancer cells

Palanca-Wessels, M. C., Booth, G. C., Convertine, A. J., Lundy, B. B., Berguig, G. Y., Press, M. F., Stayton, P. S., & Press, O. W. (2016) · Oncotarget · doi:10.18632/oncotarget.7076 · Cited by 52 · see citing works

Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics

de Vyver, T. V., Smedt, S. C. D., & Raemdonck, K. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114041 · Cited by 51 · see citing works

Synthesis, Characterization, and Evaluation of Ionizable Lysine-Based Lipids for siRNA Delivery

Walsh, C. L., Nguyen, J., Tiffany, M. R., & Szoka, F. C. (2012) · Bioconjugate Chemistry · doi:10.1021/bc300346h · Cited by 51 · see citing works

Targeting of hepatic angiotensinogen using chemically modified siRNAs results in significant and sustained blood pressure lowering in a rat model of hypertension

Olearczyk, J., Gao, S., Eybye, M. E., Yendluri, S., Andrews, L. E., Bartz, S. R., Cully, D. F., & Tadin‐Strapps, M. (2013) · Hypertension Research · doi:10.1038/hr.2013.155 · Cited by 50 · see citing works

Comprehensive analysis of lipid nanoparticle formulation and preparation for RNA delivery

Haque, M. A., Shrestha, A., Mikelis, C. M., & Mattheolabakis, G. (2024) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2024.100283 · Cited by 49 · see citing works

Effects of an Antisense Oligonucleotide Inhibitor of C‐Reactive Protein Synthesis on the Endotoxin Challenge Response in Healthy Human Male Volunteers

Noveck, R. J., Stroes, E. S. G., Flaim, J., Baker, B. F., Hughes, S. G., Graham, M. J., Crooke, R. M., & Ridker, P. M. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.001084 · Cited by 49 · see citing works

Immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics

Dobrovolskaia, M. A., & McNeil, S. E. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.1014794 · Cited by 49 · see citing works

The Dual Role of the Innate Immune System in the Effectiveness of mRNA Therapeutics

Muslimov, A. R., Tereshchenko, V., Shevyrev, D., Rogova, A. S., Lepik, K. V., Reshetnikov, V. V., & Ivanov, R. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914820 · Cited by 50 · see citing works

Interaction of Cholesterol-Conjugated Ionizable Amino Lipids with Biomembranes: Lipid Polymorphism, Structure–Activity Relationship, and Implications for siRNA Delivery

Zhang, J., Fan, H., Levorse, D. A., & Crocker, L. S. (2011) · Langmuir · doi:10.1021/la201464k · Cited by 48 · see citing works

Lipid Nanoparticles Improve Activity of Single-Stranded siRNA and Gapmer Antisense Oligonucleotides in Animals

Prakash, T. P., Lima, W. F., Murray, H. M., Elbashir, S. M., Cantley, W. L., Foster, D., Jayaraman, M., Chappell, A. E., Manoharan, M., Swayze, E. E., et al. (2013) · ACS Chemical Biology · doi:10.1021/cb4001316 · Cited by 48 · see citing works

Lipid-based nanocarriers for delivery of small interfering RNA for therapeutic use

Parashar, D., Rajendran, V., Shukla, R., & Sistla, R. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.105159 · Cited by 47 · see citing works

Centyrin ligands for extrahepatic delivery of siRNA

Klein, D., Goldberg, S. D., Theile, C. S., Dambra, R., Haskell, K., Kuhar, E., Lin, T., Parmar, R. G., Manoharan, M., Richter, M. C., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.02.015 · Cited by 48 · see citing works

An insight into the metabolic responses of ultra-small superparamagnetic particles of iron oxide using metabonomic analysis of biofluids

Feng, J., Liu, H., Zhang, L., Bhakoo, K. K., & Lu, L. (2010) · Nanotechnology · doi:10.1088/0957-4484/21/39/395101 · Cited by 45 · see citing works

Neutralization of negative charges of siRNA results in improved safety and efficient gene silencing activity of lipid nanoparticles loaded with high levels of siRNA

Sato, Y., Matsui, H., Sato, R., & Harashima, H. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.06.017 · Cited by 46 · see citing works

Strategy for selecting nanotechnology carriers to overcome immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics

Dobrovolskaia, M. A., & McNeil, S. E. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.1042857 · Cited by 44 · see citing works

Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models

Wu, S. Y., Singhania, A., Burgess, M. L., Tom, L. N., Kirkpatrick, C. M. J., Davies, N. M., & McMillan, N. A. J. (2010) · Gene Therapy · doi:10.1038/gt.2010.113 · Cited by 44 · see citing works

mRNA knockdown by single strand RNA is improved by chemical modifications

Haringsma, H. J., Li, J., Soriano, F., Kenski, D. M., Flanagan, W. M., & Willingham, A. T. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1301 · Cited by 44 · see citing works

Nanotechnology in Healthcare: Applications and Challenges

Patel, S., & Nanda, R. (2015) · Medicinal Chemistry · doi:10.4172/2161-0444.1000312 · Cited by 44 · see citing works

Innovative nanotechnologies for enhancing nucleic acids/gene therapy: Controlling intracellular trafficking to targeted biodistribution

Nakamura, T., Yamada, Y., Sato, Y., Khalil, I. A., & Harashima, H. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119329 · Cited by 44 · see citing works

Opportunities and challenges for the clinical translation of structured DNA assemblies as gene therapeutic delivery and vaccine vectors

Dobrovolskaia, M. A., & Bathe, M. (2020) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1657 · Cited by 44 · see citing works

Development of intravenously administered synthetic RNA virus immunotherapy for the treatment of cancer

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Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties

Walsh, C. L., Nguyen, J., & Szoka, F. C. (2012) · Chemical Communications · doi:10.1039/c2cc31710a · Cited by 43 · see citing works

In vivo Safety and Antitumor Efficacy of Bifunctional Small Hairpin RNAs Specific for the Human Stathmin 1 Oncoprotein

Phadke, A. P., Jay, C. M., Wang, Z., Chen, S., Liu, S., Haddock, C., Kumar, P., Pappen, B. O., Rao, D. D., Templeton, N. S., et al. (2011) · DNA and Cell Biology · doi:10.1089/dna.2011.1240 · Cited by 40 · see citing works

Versatile cationic lipids for siRNA delivery

Sparks, J., Slobodkin, G., Matar, M. M., Congo, R., Ulkoski, D., Rea-Ramsey, A., Pence, C., Rice, J. S., McClure, D., Polach, K. J., et al. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.11.006 · Cited by 39 · see citing works

Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses

Tao, W., Mao, X., Davide, J. P., Ng, B., Cai, M., Burke, P. A., Sachs, A. B., & Sepp‐Lorenzino, L. (2010) · Molecular Therapy · doi:10.1038/mt.2010.282 · Cited by 73 · see citing works

893. Systemic Delivery of Highly Active Functionalized Lipopolyamine-Formulated siRNA to Murine Lung with Reduction of Inflammation by Dexamethasone Pre-Treatment

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Combining dexamethasone and TNF-α siRNA within the same nanoparticles to enhance anti-inflammatory effect

Gürcan, S., Tsapis, N., Reynaud, F., Denis, S., Vergnaud, J., Özer, Ö., & Fattal, E. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120381 · Cited by 17 · see citing works

Septicemia in the United States Dialysis Population, 1991 to 1999

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The efficiency of lipid nanoparticles with an original cationic lipid as a siRNA delivery system for macrophages and dendritic cells

Uemura, Y., Naoi, T., Kanai, Y., & Kobayashi, K. (2018) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2018.1469149 · Cited by 24 · see citing works