The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke
Open accessAbstract
Research on commensal microbiota and its contribution to health and disease is a new and very dynamically developing field of biology and medicine. Recent experimental and clinical investigations underscore the importance of gut microbiota in the pathogenesis and course of stroke. Importantly, microbiota may influence the outcome of cerebral ischemia by modulating central nervous system antigen-specific immune responses. In this review we summarize studies linking gut microbiota with physiological function and disorders of the central nervous system. Based on these insights we speculate about targeting the gut microbiome in order to treat stroke.
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Several different microbiome-targeted approaches, including prebiotic, probiotic, and FMT strategies, have shown promising results for a variety of GI conditions in preclinical and clinical models.
“Several different microbiome-targeted approaches, including prebiotic, probiotic, and FMT strategies, have shown promising results for a variety of GI conditions in preclinical and clinical models and could be extended to pathologies involving microglia in the near future (Fond et al., 2015; Winek et al., 2016).”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Winek et al., 2016
Compared with specific-pathogen-free mice, germ-free mice show social communication disorders and increased anxiety behaviors, and these abnormal social behaviors are corrected after colonization with normal microbiota.
“compared with specific-pathogen-free (SPF) mice, germ-free (GF) mice show social communication disorders and increased anxiety behaviors, and these abnormal social behaviors are corrected after the mice are colonized with normal microbiota”
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Could the Gut Microbiota Serve as a Therapeutic Target in Ischemic Stroke?
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Anti-Inflammatory Effects of Hydrogen Sulfide in Axes Between Gut and Other Organs
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Role of the Gut Microbiota in Ischemic Stroke
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Ischaemic stroke patients present sex differences in gut microbiota
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Experimental Stroke Induces Chronic Gut Dysbiosis and Neuroinflammation in Male MicePreprint
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Gut Microbiota:Metabolic Programmers as a Lead for Deciphering Ayurvedic Pharmacokinetics
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Gut Remediation: Back to the Future
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Gut Microbiome in Stress-related Disorders: The New Approaches to Neuroinflamation syndrome
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Microbiota–Drug Interaction and Its Influence on Drug Metabolism and Toxicity
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Human Gut Microbiome as an Indicator of Human Health
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Gut Microbiota Regulation of Cerebral Stroke
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PREBIOTICS FOR ACUTE ISCHEMIC STROKE
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The Bacterial Blood Microbiota/Microbiome
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Nutrition and the Neurologic Patient
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Histamine Regulates BDNF Catabolism By Specific Gut MicrobesPreprint
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Upregulation of CXCL1 and FCGR1A is Associated With the ischemic stroke and Crohn’s DiseasePreprint
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- Authors
- Winek, K., Dirnagl, U., & Meisel, A.
- Affiliations
- Center for Stroke Research Berlin (DE)
- German Center for Neurodegenerative Diseases (DE)
- Corresponding author
- Meisel, Andreas
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 13
- Issue
- 4
- Pages
- 762-774
- ISSN
- 1878-7479 (ISSN-L)
- PMC
- PMC5081128
- OpenAlex
- W2528944013
- Cited by
- 108
- References
- 141
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 15 · 2020: 17 · 2019: 16 · 2018: 9 · 2017: 9 · 2016: 1
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neurotherapeutics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DZNE Pub (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft (NeuroCure Cluster of Excellence, Exc 257, Collaborative Research Centres SFB-TRR 84)
- Center for Stroke Research Berlin (01 EO 08 01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, stroke, cerebral ischemia, central nervous system disorders, commensal microbiota, immune response, microbiome-targeted therapy, neuroinflammation
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain, Central Nervous System Diseases, Humans, Microbiota
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