Seino, Susumu

Reconstitution of I KATP : An Inward Rectifier Subunit Plus the Sulfonylurea Receptor

Inagaki, N., Gonoi, T., Clement, J. P., Namba, N., Inazawa, J., Gonzalez, G., Aguilar-Bryan, L., Seino, S., & Bryan, J. (1995) · Science

Ion channel regulation and functionPancreatic function and diabetes

Cited by 1,709

A Family of Sulfonylurea Receptors Determines the Pharmacological Properties of ATP-Sensitive K+ Channels

Inagaki, N., Gonoi, T., Iv, J. P. C., Wang, C.-Z., Aguilar-Bryan, L., Bryan, J., & Seino, S. (1996) · Neuron

Ion channel regulation and functionPancreatic function and diabetes

Cited by 974

Molecular Biology of Mammalian Glucose Transporters

Bell, G. I., Kayano, T., Buse, J. B., Burant, C. F., Takeda, J., Lin, D., Fukumoto, H., & Seino, S. (1990) · Diabetes Care

Metabolism, Diabetes, and CancerIon Transport and Channel Regulation

Cited by 853

GLP-1 receptor activation and epac2 link atrial natriuretic peptide secretion to control of blood pressure

Kim, M., Platt, M. J., Shibasaki, T., Quaggin, S. E., Backx, P. H., Seino, S., Simpson, J. A., & Drucker, D. J. (2013) · Nature Medicine

Diabetes Treatment and ManagementBlood Pressure and Hypertension Studies

Cited by 514

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

Ozaki, N., Shibasaki, T., Kashima, Y., Miki, T., Takahashi, K., Ueno, H., Sunaga, Y., Yano, H., Matsuura, Y., Iwanaga, T., et al. (2000) · Nature Cell Biology

Cellular transport and secretionProtein Kinase Regulation and GTPase Signaling

Cited by 481

Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP

Shibasaki, T., Takahashi, H., Miki, T., Sunaga, Y., Matsumura, K., Yamanaka, M., Zhang, C., Tamamoto, A., Satoh, T., Miyazaki, J.-I., et al. (2007) · Proceedings of the National Academy of Sciences

Pancreatic function and diabetesCellular transport and secretion

Cited by 425

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

Seino, S., Shibasaki, T., & Minami, K. (2011) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 364

β Cell Dysfunction Versus Insulin Resistance in the Pathogenesis of Type 2 Diabetes in East Asians

Yabe, D., Seino, Y., Fukushima, M., & Seino, S. (2015) · Current Diabetes Reports

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 328

Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta.

Sakurai, A., Takeda, K., Ain, K., Ceccarelli, P., Nakai, A., Seino, S., Bell, G. I., Refetoff, S., & DeGroot, L. J. (1989) · Proceedings of the National Academy of Sciences

Thyroid Disorders and TreatmentsGenomics and Rare Diseases

Cited by 268

Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels.

Gribble, F. M., Tucker, S. J., Seino, S., & Ashcroft, F. M. (1998) · Diabetes

Ion channel regulation and functionPancreatic function and diabetes

Cited by 263

Glucose transporter expression in brain. cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization.

Nagamatsu, S., Kornhauser, J. M., Burant, C. F., Seino, S., Mayo, K. E., & Bell, G. I. (1992) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerIon Transport and Channel Regulation

Cited by 262

GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis

De Marinis, Y. Z., Salehi, A., Ward, C. E., Zhang, Q., Abdulkader, F., Bengtsson, M., Braha, O., Braun, M., Ramracheya, R., Amisten, S., et al. (2010) · Cell Metabolism

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 257

Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion

Gheni, G., Ogura, M., Iwasaki, M., Yokoi, N., Minami, K., Nakayama, Y., Harada, K., Hastoy, B., Wu, X., Takahashi, H., et al. (2014) · Cell Reports

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 156

The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells

Miki, T., Nagashima, K., & Seino, S. (1999) · Journal of Molecular Endocrinology

Pancreatic function and diabetesIon channel regulation and function

Cited by 147

Functional neuronal ionotropic glutamate receptors are expressed in the non-neuronal cell line MIN6.

Gonoi, T., Mizuno, N., Inagaki, N., Kuromi, H., Seino, Y., Miyazaki, J., & Seino, S. (1994) · Journal of Biological Chemistry

Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and Metabolism

Cited by 110

Rim2α Determines Docking and Priming States in Insulin Granule Exocytosis

Yasuda, T., Shibasaki, T., Minami, K., Takahashi, H., Mizoguchi, A., Uriu, Y., Numata, T., Mori, Y., Miyazaki, J.-I., Miki, T., et al. (2010) · Cell Metabolism

Cellular transport and secretionPancreatic function and diabetes

Cited by 110

Liraglutide Improves Pancreatic Beta Cell Mass and Function in Alloxan-Induced Diabetic Mice

Tamura, K., Minami, K., Kudo, M., Iemoto, K., Takahashi, H., & Seino, S. (2015) · PLOS ONE

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 70

Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c

Asahara, S.-I., Etoh, H., Inoue, H., Teruyama, K., Shibutani, Y., Ihara, Y., Kawada, Y., Bartolome, A., Hashimoto, N., Matsuda, T., et al. (2015) · Proceedings of the National Academy of Sciences

Pancreatic function and diabetesGenetic Syndromes and Imprinting

Cited by 63

Localization and Functional Role of Synaptotagmin III in Insulin Secretory Vesicles in Pancreatic β-Cells

Mizuta, M., Kurose, T., Miki, T., Shoji-Kasai, Y., Takahashi, M., Seino, S., & Matsukura, S. (1997) · Diabetes

Cellular transport and secretionPancreatic function and diabetes

Cited by 58

Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice

Fujimoto, W., Miki, T., Ogura, T., Zhang, M., Seino, Y., Satin, L. S., Nakaya, H., & Seino, S. (2009) · Diabetologia

Pancreatic function and diabetesIon channel regulation and function

Cited by 32