Rivella, Stefano

A Red carpet for iron metabolism

Muckenthaler, M. U., Rivella, S., Hentze, M. W., & Galy, B. (2017) · Cell

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 1,319

Identification of erythroferrone as an erythroid regulator of iron metabolism

Kautz, L., Jung, G., Valore, E. V., Rivella, S., Nemeth, E., & Ganz, T. (2014) · Nature Genetics

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 1,127

Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin

May, C., Rivella, S., Callegari, J., Heller, G., Gaensler, K. M. L., Luzzatto, L., & Sadelain, M. (2000) · Nature

Virus-based gene therapy researchHemoglobinopathies and Related Disorders

Cited by 567

Reactivation of developmentally silenced globin genes by forced chromatin looping

Deng, W., Rupon, J. W., Krivega, I., Breda, L., Motta, I., Jahn, K. S., Reik, A., Gregory, P. D., Rivella, S., Dean, A., et al. (2014) · Cell

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 443

Targeting iron metabolism in drug discovery and delivery

Crielaard, B. J., Lammers, T., & Rivella, S. (2017) · Nature Reviews Drug Discovery

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 352

Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin

Aschemeyer, S., Qiao, B., Stefanova, D., Valore, E. V., Sek, A. C., Ruwe, T. A., Vieth, K. R., Jung, G., Casu, C., Rivella, S., et al. (2018) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 325

Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia

Ramos, P., Casu, C., Gardenghi, S., Breda, L., Crielaard, B. J., Guy, E., Marongiu, M. F., Gupta, R., Levine, R. L., Abdel-Wahab, O., et al. (2013) · Nature Medicine

Myeloproliferative Neoplasms: Diagnosis and TreatmentErythropoietin and Anemia Treatment

Cited by 227

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

Gardenghi, S., Ramos, P., Marongiu, M. F., Melchiori, L., Breda, L., Guy, E., Muirhead, K., Rao, N., Roy, C. N., Andrews, N. C., et al. (2010) · Journal of Clinical Investigation

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 220

Iron and Reactive Oxygen Species: Friends or Foes of Cancer Cells?

Bystrom, L. M., Guzman, M. L., & Rivella, S. (2014) · Antioxidants & Redox Signaling

Ferroptosis and cancer prognosisIron Metabolism and Disorders

Cited by 212

β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism

Ginzburg, Y., & Rivella, S. (2011) · Blood

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 201

Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera

Casu, C., Oikonomidou, P. R., Chen, H., Nandi, V., Ginzburg, Y., Prasad, P., Fleming, R. E., Shah, Y. M., Valore, E. V., Nemeth, E., et al. (2016) · Blood

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 148

Iron metabolism under conditions of ineffective erythropoiesis in β-thalassemia

Rivella, S. (2019) · Blood

Hemoglobinopathies and Related DisordersIron Metabolism and Disorders

Cited by 120

Decreased hepcidin mRNA expression in thalassemic mice

Adamsky, K., Weizer, O., Amariglio, N., Breda, L., Harmelin, A., Rivella, S., Rachmilewitz, E., & Rechavi, G. (2004) · British Journal of Haematology

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 108

Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus

Gardenghi, S., Renaud, T. M., Meloni, A., Casu, C., Crielaard, B. J., Bystrom, L. M., Greenberg-Kushnir, N., Sasu, B. J., Cooke, K. S., & Rivella, S. (2014) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 107

Gene therapy of hemoglobinopathies: progress and future challenges

Ikawa, Y., Miccio, A., Magrin, E., Kwiatkowski, J. L., Rivella, S., & Cavazzana, M. (2019) · Human Molecular Genetics

Virus-based gene therapy researchHemoglobinopathies and Related Disorders

Cited by 86

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers

Breda, L., Motta, I., Lourenco, S., Gemmo, C., Deng, W., Rupon, J. W., Abdulmalik, O. Y., Manwani, D., Blobel, G. A., & Rivella, S. (2016) · Blood

Hemoglobinopathies and Related DisordersVirus-based gene therapy research

Cited by 83

Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell‐line HepG2 induced by thalassaemic sera

Weizer‐Stern, O., Adamsky, K., Amariglio, N., Levin, C., Koren, A., Breuer, W., Rachmilewitz, E., Breda, L., Rivella, S., Ioav Cabantchik, Z., et al. (2006) · British Journal of Haematology

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 80

mRNA expression of iron regulatory genes in β-thalassemia intermedia and β-thalassemia major mouse models

Weizer-Stern, O., Adamsky, K., Amariglio, N., Rachmilewitz, E., Breda, L., Rivella, S., & Rechavi, G. (2006) · American Journal of Hematology

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 71

Minihepcidins improve ineffective erythropoiesis and splenomegaly in a new mouse model of adult β-thalassemia major

Casu, C., Chessa, R., Liu, A., Gupta, R., Drakesmith, H., Fleming, R., Ginzburg, Y. Z., MacDonald, B., & Rivella, S. (2020) · Haematologica

Hemoglobinopathies and Related DisordersIron Metabolism and Disorders

Cited by 50

Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response

Richardson, C. L., Delehanty, L. L., Bullock, G. C., Rival, C. M., Tung, K. S., Kimpel, D. L., Gardenghi, S., Rivella, S., & Goldfarb, A. N. (2013) · Journal of Clinical Investigation

Erythropoietin and Anemia TreatmentIron Metabolism and Disorders

Cited by 47

Hepcidin and Hfe in iron overload in β‐thalassemia

Gardenghi, S., Ramos, P., Follenzi, A., Rao, N., Rachmilewitz, E. A., Giardina, P. J., Grady, R. W., & Rivella, S. (2010) · Annals of the New York Academy of Sciences

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 27