Decreased hepcidin mRNA expression in thalassemic mice
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Thalassaemia predisposes towards PE and causes hepcidin to decrease and NGAL to increase, with consequent iron dysregulation.
“We note in this context that thalassaemia not only predisposes towards PE but is known in general to cause hepcidin to decrease and NGAL to increase [352,353,356,535], with consequent and inevitable iron dysregulation.”
The amount of hepcidin mRNA in liver cells is decreased in response to hypoxia and ineffective erythropoiesis and induced in response to treatment with lipopolysaccharide or by inflammation of other etiologies.
“In addition, the amount of hepcidin mRNA in liver cells is decreased in response to hypoxia and ineffective erythropoiesis (overlapping with the response to iron deficiency) 99,105 and induced in response to treatment with lipopolysaccharide or by inflammation of other etiologies.92,99”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [105]
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Cites
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“The Hbb mouse (Th3/1) recapitulates the features of b-thalassemia intermedia in humans, including lowhemoglobin levels, aberrant erythrocytemorphology, increased reticulocyte count, ineffective and extramedullary erythropoiesis, hepatosplenomegaly, and liver and spleen iron overload.(8,9) In contrast to human patients…”
Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis
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“…DMT1 FPN TfR1 TfR2 ferritin 0.0001 0.001 0.01 0.1 1 10 Control P16 R16 RP16 P48 R48 RP48 relative to beta-actin * *** ** † 672 Vokurka et al. Vol. 55 (hpx/hpx) and in thalassemic mice which are both characterized by decreased hepcidin mRNA expression (Weinstein et al. 2002, Adamsky et al. 2004).”
InfluentialSchmidt, P. J., Toudjarska, I., Sendamarai, A. K., Racie, T., Milstein, S., Bettencourt, B. R., Hettinger, J., Bumcrot, D., & Fleming, M. D. (2013) · Blood · doi:10.1182/blood-2012-09-453977 · Cited by 204 · see citing works
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Transferrin therapy ameliorates disease in β-thalassemic mice
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“Relatively low levels of hepcidin messenger RNA expression in the liver are also characteristic of mouse models of β-thalassemi”
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“Hepcidin is only regulated at the transcriptional level, and expression is inhibited by anemia, hypoxia (19), and ineffective erythropoiesis (20), and stimulated by iron loading and inflammation.”
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“Its levels are decreased in β-thalasseamia due to the ineffective erythropoiesis and subsequent enhanced erythropoietic activity, which increases iron demand [139,3].”
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“Data from a murine model of thalassemia suggested that hepcidin levels are low [15].”
BackgroundDecreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in β-thalassemia
Libani, I. V., Guy, E. C., Melchiori, L., Schirò, R., Ramos, P., Breda, L., Scholzen, T. E., Chadburn, A., Liu, Y., Kernbach, M., et al. (2008) · Blood · doi:10.1182/blood-2007-12-126938 · Cited by 162 · see citing works
Self-citationDeletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia
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Iron Metabolism: Interactions with Normal and Disordered ErythropoiesisPreprint
Ganz, T., & Nemeth, E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011668 · Cited by 154 · see citing works
“…prominent under pathological conditions of expanded but ineffective erythropoiesis, seen in b-thalassemia and congenital dyserythropoietic anemias (Adamsky et al. 2004; Papanikolaou et al. 2005) where the large number of apoptosing erythrocyte precursors could generate additional suppressive…”
BackgroundInfluentialMinihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera
Casu, C., Oikonomidou, P. R., Chen, H., Nandi, V., Ginzburg, Y., Prasad, P., Fleming, R. E., Shah, Y. M., Valore, E. V., Nemeth, E., et al. (2016) · Blood · doi:10.1182/blood-2015-10-676742 · Cited by 148 · see citing works
“In b-thalassemia and anemia, increased EPO levels and expanded but ineffective erythropoiesis result in lowered hepcidin levels, increased intestinal iron absorption, and TSAT.3,6,8,21,27 In turn, excess iron contributes to the development and worsening of ineffective erythropoiesis and reduced erythroblast maturation…”
BackgroundPakbaz, Z., Fischer, R., Fung, E. B., Nielsen, P., Harmatz, P., & Vichinsky, E. P. (2007) · Pediatric Blood & Cancer · doi:10.1002/pbc.21275 · Cited by 128 · see citing works
“hypoxia or hyperactive bone marrow due to low hemoglobin observed in our nTx-Thal patients would down regulate hepcidin [14,15] and increase iron absorption and iron accumulation in”
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Self-citationHereditary Hemochromatosis: Genetic Complexity and New Diagnostic Approaches
Swinkels, D. W., Janssen, M. C. H., Bergmans, J., & Marx, J. J. M. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.068684 · Cited by 116 · see citing works
“In pilot-scale studies, hepcidin is found to be suppressed for both disorders, with a median hepcidin/ferritin ratio in thalassemia syndromes that is only 5% of that of controls (176), indicating that the erythroid iron needs appears to be dominant over the inhibitory signals of iron stores (80, 127, 177, 178).”
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Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia
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“Hepcidin expression is decreased in several disorders of secondary hemochromatosis (16, 17).”
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Donovan, A., Roy, C. N., & Andrews, N. C. (2006) · Physiology · doi:10.1152/physiol.00052.2005 · Cited by 100 · see citing works
Interacting signals in the control of hepcidin expression
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“In the case of mice affected by β-thalassemia intermedia, it has been observed that they exhibit very low hepcidin levels during the first months of life (16,89,91,97-99).”
BackgroundSelf-citationHepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53
Weizer‐Stern, O., Adamsky, K., Margalit, O., Ashur‐Fabian, O., Givol, D., Amariglio, N., & Rechavi, G. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06638.x · Cited by 94 · see citing works
“Hepcidin is upregulated in response to increased body iron levels (Gehrke et al, 2003) or to inflammation (Nemeth et al, 2004b), and is downregulated in response to hypoxia, anaemia (Nicolas et al, 2002; Adamsky et al, 2004) and oxidative stress (Choi et al, 2007).”
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Ineffective Erythropoiesis: Anemia and Iron Overload
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Self-citationThe role of antioxidants and iron chelators in the treatment of oxidative stress in thalassemia
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“We have previously shown that HAMP mRNA is decreased in the livers of Hbbth3/+ b-thalassaemia intermedia (TI) mice (Adamsky et al, 2004) and even more so in the Hbbth3/th3 TM mouse model (WeizerStern et al, 2006).”
BackgroundResultSelf-citationSchmidt, P. J., Racie, T., Westerman, M., Fitzgerald, K., Butler, J. S., & Fleming, M. D. (2015) · American Journal of Hematology · doi:10.1002/ajh.23934 · Cited by 77 · see citing works
“Similar to their human counterparts, these animals have moderately severe, transfusion-independent hypochromic, microcytic anemia associated and ineffective erythropoeisis resulting in splenomegaly, hepcidin suppression, and secondary iron overload [4–7].”
BackgroundHepcidin: A novel peptide hormone regulating iron metabolism
Singh, B. M., Arora, S., Agrawal, P., & Gupta, S. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.02.014 · Cited by 74 · see citing works
-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload
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“…one of the first monogenic diseases to be described and represents a global health problem, only recently has the scientific community started to focus on the real molecular mechanisms that underlie this disease, opening new and exciting therapeutic perspectives for thalassemic patients worldwide.”
Self-citationWeizer-Stern, O., Adamsky, K., Amariglio, N., Rachmilewitz, E., Breda, L., Rivella, S., & Rechavi, G. (2006) · American Journal of Hematology · doi:10.1002/ajh.20549 · Cited by 71 · see citing works
“We have shown previously that hepcidin liver mRNA expression is decreased in the liver of Hbbth3/þ b-thalassemia intermedia mouse model [16].”
Self-citationDecreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice
Li, H., Choesang, T., Bao, W., Chen, H., Feola, M., Garcia‐Santos, D., Li, J., Sun, S., Follenzi, A., Pham, P., et al. (2017) · Blood · doi:10.1182/blood-2016-09-742387 · Cited by 71 · see citing works
“Mouse models of b-thalassemia also exhibit relatively low hepcidin.(10) Lack of appropriately increased hepcidin despite increased parenchymal iron stores suggests that a competing signal is counterregulating hepcidin expression,(11-13) establishing b-thalassemia as an important opportunity for evaluating erythroid re…”
BackgroundSelf-citationHepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait
Jones, E., Pasricha, S.-R., Allen, A., Evans, P., Fisher, C. A., Wray, K., Premawardhena, A., Bandara, D., Perera, A., Webster, C., et al. (2015) · Blood · doi:10.1182/blood-2014-10-606491 · Cited by 68 · see citing works
“Hepcidin concentrations are suppressed in b-thalassemia,(11,12) as is hepatic HAMP mRNA expression in patients with thalassemia major (TM)(13,14) and in the C57Bl/6 Hbb thalassemia mouse model.(15) However, patients with thalassemia intermedia exhibit lower liver HAMP mRNA than those with TM,(14) probably because of t…”
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Hepcidin: an important new regulator of iron homeostasis
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“Thalassaemic mice with iron overload have significantly lower hepcidin expression compared with controls, supporting the dominant force of anaemia over hepatic iron in hepcidin induction (Adamsky et al., 2004).”
BackgroundLyoumi, S., Abitbol, M., Andrieu, V., Hénin, D., Robert, E., Schmitt, C., Gouya, L., de Verneuil, H., Deybach, J., Montagutelli, X., et al. (2006) · Blood · doi:10.1182/blood-2006-04-014142 · Cited by 63 · see citing works
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“severe β-thalassemia intermedia (Hbbth3/+) (Table 1) [24,37,38].”
BackgroundLiver expression of hepcidin and other iron genes in two mouse models of beta-thalassemia.
Franceschi, L. D., Daraio, F., Filippini, A., Carturan, S., Muchitsch, E. M., Roetto, A., & Camaschella, C. (2006) · PubMed · Cited by 57 · see citing works
Chapter 6 Iron Homeostasis and Erythropoiesis
Wrighting, D. M., & Andrews, N. C. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(07)00006-3 · Cited by 58 · see citing works
Iron dysregulation in beta-thalassemia
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Animal models with enhanced erythropoiesis and iron absorption
Latunde-Dada, G. O., McKie, A. T., & Simpson, R. J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.12.007 · Cited by 50 · see citing works
“Hepcidin levels are decreased in beta thalassaemic mice [106].”
BackgroundHoofnagle, M. H., Wamhoff, B. R., & Owens, G. K. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21761 · Cited by 46 · see citing works
“reduced cholesteryl ester transfer protein– mediated transfer of triglyceride to LDLs and subsequent lipolysis (10, 13).”
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“Hepatic Hamp expression was decreased, as shown previously (Adamsky et al, 2004), however, in agreement with our PHZ model, Bmp6 expression was significantly increased (Fig 6C).”
ResultModulation of Hepcidin as Therapy for Primary and Secondary Iron Overload Disorders
Schmidt, P. J., & Fleming, M. D. (2014) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2013.11.004 · Cited by 43 · see citing works
“roblasts) seem to uniquely potently suppress hepcidin production even in the presence of systemic iron overload.(7) The factor or factors that communicate this signal from the bonemarrow to the liver to suppress hepcidin have been termed the erythroid regulator of iron metabolism.”
BackgroundIron overload in myelodysplastic syndromes
Mahesh, S. A., Ginzburg, Y. Z., & Verma, A. (2008) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190701843221 · Cited by 40 · see citing works
“A mouse model of b-thalassemia also indicates that hepcidin mRNA expression is decreased [18].”
BackgroundHAMP promoter hypomethylation and increased hepcidin levels as biomarkers for Kawasaki disease
Huang, Y., Kuo, H., Li, S.-C., Cai, X.-Y., Liu, S., & Kuo, H. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.02.017 · Cited by 34 · see citing works
Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis
Winder, A., Lefkowitz, R., Ghoti, H., Leiba, M., Ganz, T., Nemeth, E., & Rachmilewitz, E. A. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07225.x · Cited by 34 · see citing works
“Hepcidin is increased in response to increased body iron levels, transferrin saturation (Ganz & Nemeth, 2006) or inflammation, and is decreased in response to hypoxia, (Nicolas et al, 2002) erythropoietic activity (Adamsky et al, 2004) and oxidative stress (Choi et al, 2007).”
BackgroundSelf-citationRegulation of Iron Absorption in Hemoglobinopathies
Rechavi, G., & Rivella, S. (2008) · Current Molecular Medicine · doi:10.2174/156652408786241401 · Cited by 32 · see citing works
Self-citationExogenous iron increases hemoglobin in β–thalassemic mice
Ginzburg, Y. Z., Rybicki, A. C., Suzuka, S. M., Hall, C. B., Breuer, W. V., Cabantchik, Z. I., Bouhassira, E. E., Fabry, M. E., & Nagel, R. L. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.10.004 · Cited by 33 · see citing works
Schmidt, P. J., Liu, K., Visner, G. A., Fitzgerald, K. J., Fishman, S., Racie, T., Hettinger, J. L., Butler, J. S., & Fleming, M. D. (2018) · American Journal of Hematology · doi:10.1002/ajh.25079 · Cited by 29 · see citing works
Hepcidin and Hfe in iron overload in β‐thalassemia
Gardenghi, S., Ramos, P., Follenzi, A., Rao, N., Rachmilewitz, E. A., Giardina, P. J., Grady, R. W., & Rivella, S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05595.x · Cited by 27 · see citing works
Self-citationLiver-gut axis in the regulation of iron homeostasis
Darshan, D. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i35.4737 · Cited by 31 · see citing works
Pathophysiology and therapy for haemoglobinopathies; Part II: thalassaemias
Urbinati, F., Madigan, C., & Malik, P. (2006) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399406010805 · Cited by 26 · see citing works
Liu, J., Liu, W., Liu, Y., Miao, Y., Guo, Y., Song, H., Wang, F., Zhou, H., Ganz, T., Yan, B., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.209874 · Cited by 30 · see citing works
“The common mechanism is lower level of hepcidin compared to that in Wt mice, giving rise to enhanced dietary iron uptake and iron egress out of macrophages and consequently iron deposition in various organs, especially the liver.(36,43) However in β-thalassemias, unlike in HH, ineffective erythropoiesis and hemolysis…”
BackgroundBeta‐thalassemia and the advent of new interventions beyond transfusion and iron chelation
Chauhan, W., Shoaib, S., Fatma, R., Zaka‐ur‐Rab, Z., & Afzal, M. (2022) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15343 · Cited by 25 · see citing works
“ship between relatively reduced hepcidin mRNA levels in the liver and iron overload in this disorder (Table 1).(56,57) IE can be therapeutically targeted at different sites as follows:”
BackgroundOlivera, J. D., Zhang, V., Nemeth, E., & Ganz, T. (2023) · Blood Advances · doi:10.1182/bloodadvances.2022009307 · Cited by 23 · see citing works
“Studies in human subjects and mice have documented that augmented erythropoietic activity, whether in response to blood loss, EPO, or ineffective erythropoiesis, generates 1 or more signals that suppress the production of the iron-regulatory hormone hepcidin.(3,4,7,8,12,25,26) ERFE, a glycoprotein erythrokine produced…”
BackgroundFuture alternative therapies for β-thalassemia
Rivella, S., & Rachmilewitz, E. A. (2009) · Expert Review of Hematology · doi:10.1586/ehm.09.56 · Cited by 23 · see citing works
Self-citationClinical Perspectives on Hereditary Hemochromatosis
Ayonrinde, O. T., Milward, E. A., Chua, A. C. G., Trinder, D., & Olynyk, J. K. (2008) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360802335716 · Cited by 23 · see citing works
Where do we go now with low molecular weight heparin use in obstetric care?
Patel, J. P., & Hunt, B. J. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03048.x · Cited by 20 · see citing works
What regulates hepcidin in poly-transfused β-Thalassemia Major: Erythroid drive or store drive?
Chauhan, R., Sharma, S., & Chandra, J. (2014) · Indian Journal of Pathology and Microbiology · doi:10.4103/0377-4929.130891 · Cited by 20 · see citing works
Saad, H. K. M., Rahman, A. A. A., Ghani, A. S. A., Taib, W. R. W., Ismail, I., Johan, M. F., Al-wajeeh, A. S., & Al‐Jamal, H. A. N. (2022) · Biomedicines · doi:10.3390/biomedicines10010189 · Cited by 22 · see citing works
“Hepcidin expression in thalassemia was first reported in a mouse model of severe anemia (C57BI/6 Hbbth3/+) [38].”
BackgroundInfluentialBreda, L., Gardenghi, S., Guy, E. C., Rachmilewitz, E. A., Weizer‐Stern, O., Adamsky, K., Amariglio, N., Rechavi, G., Giardina, P. J., Grady, R. W., et al. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1345.069 · Cited by 19 · see citing works
Self-citationHepcidin generated by hepatoma cells inhibits iron export from co-cultured THP1 monocytes
Andriopoulos, B., & Pantopoulos, K. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.10.025 · Cited by 17 · see citing works
“mouse models of hemochromatosis [17–23] and thalassemia [24].”
BackgroundCampos‐Sánchez, J. C., Serna-Duque, J. A., Alburquerque, C., Guardiola, F. A., & Esteban, M. Á. (2024) · Marine Biotechnology · doi:10.1007/s10126-024-10293-0 · Cited by 15 · see citing works
“On the other hand, since hepcidins seem to be regulated only at the transcriptional level (Nicolas et al. 2002; Adamsky et al. 2004), the overrepresented presence of various inflammatory TFBS such as STAT3 or NF-κB (REL and RELA) located in their promoter regions could be a very relevant data in…”
BackgroundRosato, B. E., Marra, R., D’Onofrio, V., Giudice, F. D., Monica, S. D., Iolascon, A., Andolfo, I., & Russo, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031304 · Cited by 13 · see citing works
“It is now clear that stimulated erythrocyte precursors produce one or more hepcidin-suppressive factors [31,32].”
BackgroundPathogenic Mechanisms in Thalassemia II
Ganz, T., & Nemeth, E. (2023) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2022.12.006 · Cited by 15 · see citing works
Fan, Q., Zhou, Y., Yu, C., Chen, J., Shi, X., Zhang, Y., & Zheng, W. (2016) · PeerJ · doi:10.7717/peerj.2413 · Cited by 11 · see citing works
“The response of these Fe regulatory proteins to variations of systemic Fe status has been established in literature (Adamsky et al., 2004; Gehrke et al., 2003; Theurl et al., 2008); however their expression at the translational level in the human body as affected by Mn exposure has never been investigated.”
BackgroundZaman, B. A., & Ibrahim, S. (2022) · Hemoglobin · doi:10.1080/03630269.2022.2083969 · Cited by 7 · see citing works
Saad, H., Taib, W. R. W., Ismail, I., Johan, M. F., Al-wajeeh, A. S., & Al‐Jamal, H. A. N. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10838 · Cited by 8 · see citing works
“These findings were similar to previous studies reporting that HEPC expression in β‐thalassemia is downregulated in β‐thalassemia mice (36,37).”
ResultHepcidin suppression in β-thalassemia is associated with the down-regulation of atonal homolog 8
Upanan, S., McKie, A. T., Latunde-Dada, G. O., Roytrakul, S., Uthaipibull, C., Pothacharoen, P., Kongtawelert, P., Fucharoen, S., & Srichairatanakool, S. (2017) · International Journal of Hematology · doi:10.1007/s12185-017-2231-3 · Cited by 5 · see citing works
Métabolisme du fer : physiologie et pathologie
Beaumont, C., & Girot, R. (2010) · Encyclopédie médico-chirurgicale. Hématologie · doi:10.1016/s1155-1984(10)49948-3 · Cited by 6 · see citing works
Troadec, M., Loréal, O., & Brissot, P. (2006) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(06)40611-9 · Cited by 5 · see citing works
Fetal Factors Disrupt Placental and Maternal Iron Homeostasis in Murine β-Thalassemia
Yang, Y., Woloshun, R. R., Lee, J. K., Ebea, P. O., Zhu, S., Nemeth, E., Garrick, L. M., Garrick, M. D., & Collins, J. F. (2023) · Blood · doi:10.1182/blood.2022018839 · Cited by 4 · see citing works
Duca, L., Delbini, P., Nava, I., Cappellini, M. D., & Meo, A. (2009) · Internal and Emergency Medicine · doi:10.1007/s11739-009-0306-8 · Cited by 4 · see citing works
“thalassemia major) and in patients with thalassemia major urinary hepcidin was disproportionately suppressed in regard to iron burden [ 2 ].”
BackgroundKobayashi, Y., Wakasugi, E., Ohbuchi, T., YOKOYAMA, M., Yasui, R., Kuwahata, M., Nakabou, Y., & Kido, Y. (2011) · Biomedical Research-tokyo · Cited by 4 · see citing works
Yu, Y., Woloshun, R. R., Lee, J. K., Ebea, P. O., Shine, J. S., Zhu, S., He, Y., & Collins, J. F. (2024) · Blood Advances · doi:10.1182/bloodadvances.2024013333 · Cited by 3 · see citing works
“39,40 Low hepcidin in young Th3/+ mice may increase iron absorption and precipitate iron loading; however, unlike the situation in humans, 41-43 hepcidin levels normalize in Th3/+ mice as they approach adulthood.”
ДОНАЦІЇ КРОВІ І МЕТАБОЛІЗМ ЗАЛІЗА
Видиборець, С. В., & Дерпак, Ю. (2022) · Іnternational Science Group eBooks · doi:10.46299/979-8-88831-933-8 · Cited by 3 · see citing works
Molecular Regulation of Systemic Iron Metabolism
Ganz, T., & Vaulont, S. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-485-2_9 · Cited by 3 · see citing works
The Role of Hepcidin in Iron Homeostasis
Ganz, T. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-462-9_3 · Cited by 3 · see citing works
“, 2007) and in the mouse models of b-thalassemia (Adamsky et al., 2004; Breda et al., 2005; Gardenghi et al., 2007).”
BackgroundDisorders of Red Cell Production and the Iron-Loading Anemias
Rivella, S. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-485-2_16 · Cited by 2 · see citing works
Self-citationNormal iron absorption and metabolism
Barton, J. C., Edwards, C. Q., Phatak, P. D., Britton, R. S., & Bacon, B. R. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777035.004 · Cited by 1 · see citing works
Role of Hepcidin in Dysregulation of Iron Metabolism and Anemia of Chronic Diseases
Singh, B. M., Arora, S., Gupta, S., & Saxena, A. (2012) · BiblioBoard Library Catalog (Open Research Library) · doi:10.5772/27286 · Cited by 1 · see citing works
“Murine models of human thalassemia, have also demonstrated decreased hepcidin mRNA expression [84].”
BackgroundMécanismes impliqués dans la régulation de l’absorption intestinale du fer
Nicolas, G., Vaulont, S., & Beaumont, C. (2004) · Cahiers de Nutrition et de Diététique · doi:10.1016/s0007-9960(04)94453-7 · Cited by 1 · see citing works
- Authors
- Adamsky, K., Weizer, O., Amariglio, N., Breda, L., Harmelin, A., Rivella, S., Rachmilewitz, E., & Rechavi, G.
- Affiliations
- Tel Aviv University (IL)
- Cornell University (US)
- Weizmann Institute of Science (IL)
- Wolfson Medical Center (IL)
- Corresponding author
- Rachmilewitz, Eliezer
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 2003-12-11
- Volume
- 124
- Issue
- 1
- Pages
- 123-124
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W1983551732
- Cited by
- 108
- References
- 9
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 2 · 2012: 6
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Haematology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Hospitals of Leicester NHS Trust
- Strong
- British Society for Haematology
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Keywords
- hepcidin, mRNA expression, thalassemia, iron metabolism
- MeSH terms
- Animals, Mice, Inbred C57BL, RNA, Messenger, Thalassemia, Antimicrobial Cationic Peptides, Mice, Hepcidins
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