Takamura, Toshinari

A liver-derived secretory protein, selenoprotein P, causes insulin resistance

Misu, H., Takamura, T., Takayama, H., Hayashi, H., Matsuzawa-Nagata, N., Kurita, S., Ishikura, K., Ando, H., Takeshita, Y., Ota, T., et al. (2010) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesSelenium in Biological Systems

Cited by 583

Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria.

Nakamura, S., Takamura, T., Matsuzawa-Nagata, N., Takayama, H., Misu, H., Noda, H., Nabemoto, S., Kurita, S., Ota, T., Ando, H., et al. (2009) · Journal of Biological Chemistry

Liver Disease Diagnosis and TreatmentMetabolism, Diabetes, and Cancer

Cited by 426

Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma

Yasui, K., Hashimoto, E., Komorizono, Y., Koike, K., Arii, S., Imai, Y., Shima, T., Kanbara, Y., Saibara, T., Mori, T., et al. (2011) · Clinical Gastroenterology and Hepatology

Liver Disease Diagnosis and TreatmentHepatocellular Carcinoma Treatment and Prognosis

Cited by 420

Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial

Ueki, K., Sasako, T., Okazaki, Y., Kato, M., Okahata, S., Katsuyama, H., Haraguchi, M., Morita, A., Ohashi, K., Hara, K., et al. (2017) · The Lancet Diabetes & Endocrinology

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 313

LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance

Lan, F., Misu, H., Chikamoto, K., Takayama, H., Kikuchi, A., Mohri, K., Takata, N., Hayashi, H., Matsuzawa-Nagata, N., Takeshita, Y., et al. (2014) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesLiver Disease Diagnosis and Treatment

Cited by 158

Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle

Misu, H., Takayama, H., Saito, Y., Mita, Y., Kikuchi, A., Ishii, K.-A., Chikamoto, K., Kanamori, T., Tajima, N., Lan, F., et al. (2017) · Nature Medicine

Exercise and Physiological ResponsesSelenium in Biological Systems

Cited by 156

Transgenic Mice Overexpressing Type 2 Nitric-oxide Synthase in Pancreatic β Cells Develop Insulin-dependent Diabetes without Insulitis

Takamura, T., Kato, I., Kimura, N., Nakazawa, T., Yonekura, H., Takasawa, S., & Okamoto, H. (1998) · Journal of Biological Chemistry

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 145

Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes

Misu, H., Ishikura, K., Kurita, S., Takeshita, Y., Ota, T., Saito, Y., Takahashi, K., Kaneko, S., & Takamura, T. (2012) · PLoS ONE

Adipokines, Inflammation, and Metabolic DiseasesSelenium in Biological Systems

Cited by 105

Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes

Misu, H., Takamura, T., Matsuzawa, N., Shimizu, A., Ota, T., Sakurai, M., Ando, H., Arai, K., Yamashita, T., Honda, M., et al. (2007) · Diabetologia

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 102

Obesity Upregulates Genes Involved in Oxidative Phosphorylation in Livers of Diabetic Patients

Takamura, T., Misu, H., Matsuzawa‐Nagata, N., Sakurai, M., Ota, T., Shimizu, A., Kurita, S., Takeshita, Y., Ando, H., Honda, M., et al. (2008) · Obesity

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 96

The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men

Sargeant, J. A., Aithal, G. P., Takamura, T., Misu, H., Takayama, H., Douglas, J. A., Turner, M. C., Stensel, D. J., Nimmo, M. A., Webb, D. R., et al. (2018) · Applied Physiology, Nutrition, and Metabolism

Adipokines, Inflammation, and Metabolic DiseasesFibroblast Growth Factor Research

Cited by 56

Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples

Sugiyama, M., Kikuchi, A., Misu, H., Igawa, H., Ashihara, M., Kushima, Y., Honda, K., Suzuki, Y., Kawabe, Y., Kaneko, S., et al. (2018) · PLoS ONE

Adipokines, Inflammation, and Metabolic DiseasesLiver Disease Diagnosis and Treatment

Cited by 52

Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice

Chikamoto, K., Misu, H., Takayama, H., Kikuchi, A., Ishii, K.-A., Lan, F., Takata, N., Tajima-Shirasaki, N., Takeshita, Y., Tsugane, H., et al. (2016) · Biochemical and Biophysical Research Communications

Adipokines, Inflammation, and Metabolic DiseasesLiver Disease Diagnosis and Treatment

Cited by 37

Vildagliptin vs liraglutide as a second‐line therapy switched from sitagliptin‐based regimens in patients with type 2 diabetes: A randomized, parallel‐group study

Takeshita, Y., Takamura, T., Kita, Y., Otoda, T., Kato, K., Wakakuri, H., Yamada, M., Misu, H., Matsushima, Y., Kaneko, S., et al. (2015) · Journal of Diabetes Investigation

Diabetes Treatment and ManagementDiabetes Management and Research

Cited by 35

Acute hyperenergetic, high-fat feeding increases circulating FGF21, LECT2, and fetuin-A in healthy men

Willis, S. A., Sargeant, J. A., Yates, T., Takamura, T., Takayama, H., Gupta, V., Brittain, E., Crawford, J., Parry, S. A., Thackray, A. E., et al. (2020) · The Journal of Nutrition

Fibroblast Growth Factor ResearchAdipokines, Inflammation, and Metabolic Diseases

Cited by 34

Role of selenoprotein P expression in the function of pancreatic β cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation

Kitabayashi, N., Nakao, S., Mita, Y., Arisawa, K., Hoshi, T., Toyama, T., Ishii, K.-A., Takamura, T., Noguchi, N., & Saito, Y. (2022) · Free Radical Biology and Medicine

Selenium in Biological SystemsPancreatic function and diabetes

Cited by 24

Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases

Abuduwaili, H., Kamoshita, K., Ishii, K.-A., Takahashi, K., Abuduyimiti, T., Qifang, L., Isobe, Y., Goto, H., Nakano, Y., Takeshita, Y., et al. (2023) · American Journal of Physiology-Endocrinology and Metabolism

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 7