Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes
Open accessAbstract
BACKGROUND: We recently identified selenoprotein P (SeP) as a liver-derived secretory protein that causes insulin resistance in the liver and skeletal muscle; however, it is unknown whether and, if so, how SeP acts on adipose tissue. The present study tested the hypothesis that SeP is related to hypoadiponectinemia in patients with type 2 diabetes. METHODOLOGY/PRINCIPAL FINDINGS: We compared serum levels of SeP with those of adiponectin and other clinical parameters in 36 patients with type 2 diabetes. We also measured levels of blood adiponectin in SeP knockout mice. Circulating SeP levels were positively correlated with fasting plasma glucose (r = 0.35, P = 0.037) and negatively associated with both total and high-molecular adiponectin in patients with type 2 diabetes (r = -0.355, P = 0.034; r = -0.367, P = 0.028). SeP was a predictor of both total and high-molecular adiponectin, independently of age, body weight, and quantitative insulin sensitivity index (β = -0.343, P = 0.022; β = -0.357, P = 0.017). SeP knockout mice exhibited an increase in blood adiponectin levels when fed regular chow or a high sucrose, high fat diet. CONCLUSIONS/SIGNIFICANCE: These results suggest that overproduction of liver-derived secretory protein SeP is connected with hypoadiponectinemia in patients with type 2 diabetes.
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SeP is a glycoprotein secreted predominantly from the liver and is upregulated by selenium and glucose supplies but downregulated by insulin and adiponectin.
“Selenoprotein P (SeP) is a glycoprotein that is secreted predominantly from the liver and is upregulated by selenium and glucose supplies but downregulated by insulin and adiponectin [260,261].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [261]
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- Authors
- Misu, H., Ishikura, K., Kurita, S., Takeshita, Y., Ota, T., Saito, Y., Takahashi, K., Kaneko, S., & Takamura, T.
- Affiliations
- Kanazawa University (JP)
- Doshisha University (JP)
- Hokkaido Pharmaceutical University (JP)
- Corresponding author
- Takamura, Toshinari
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-04-04
- Volume
- 7
- Issue
- 4
- Pages
- e34952
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3319626
- OpenAlex
- W2088893515
- Cited by
- 105
- References
- 32
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 4
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) (submittedVersion, cc-by-nc-nd)
- Funders
- Vanderbilt University
- School of Medicine, Vanderbilt University
- Japan Society for the Promotion of Science (23791022, 23591301, 23249042)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- selenoprotein P, adiponectin, type 2 diabetes, hypoadiponectinemia, adipose tissue, high-fat high-sugar diet, insulin resistance, fasting blood glucose
- MeSH terms
- Aged, Animals, Blood Glucose, Diabetes Mellitus, Type 2, Fasting, Female, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Mice, Knockout, Dietary Sucrose, Selenoprotein P, Mice, Adiponectin, Diet, High-Fat
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