Klein, Robyn S.

A complement–microglial axis drives synapse loss during virus-induced memory impairment

Vasek, M. J., Garber, C., Dorsey, D., Durrant, D. M., Bollman, B., Soung, A., Yu, J., Perez-Torres, C., Frouin, A., Wilton, D. K., et al. (2016) · Nature

Neuroinflammation and Neurodegeneration MechanismsMosquito-borne diseases and control

Cited by 671

Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2)

Izikson, L., Klein, R. S., Charo, I. F., Weiner, H. L., & Luster, A. D. (2000) · The Journal of Experimental Medicine

Multiple Sclerosis Research StudiesChemokine receptors and signaling

Cited by 584

Neuronal CXCL10 Directs CD8 + T-Cell Recruitment and Control of West Nile Virus Encephalitis

Klein, R. S., Lin, E., Zhang, B., Luster, A. D., Tollett, J., Samuel, M. A., Engle, M., & Diamond, M. S. (2005) · Journal of Virology

Chemokine receptors and signalingMosquito-borne diseases and control

Cited by 424

Quantification of increased cellularity during inflammatory demyelination

Wang, Y., Wang, Q., Haldar, J. P., Yeh, F.-C., Xie, M., Sun, P., Tu, T.-W., Trinkaus, K., Klein, R. S., Cross, A. H., et al. (2011) · Brain

Advanced Neuroimaging Techniques and ApplicationsMultiple Sclerosis Research Studies

Cited by 384

TREM2 regulates microglial cell activation in response to demyelination in vivo

Cantoni, C., Bollman, B., Licastro, D., Xie, M., Mikesell, R., Schmidt, R., Yuede, C. M., Galimberti, D., Olivecrona, G., Klein, R. S., et al. (2015) · Acta Neuropathologica

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 296

T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses

Garber, C., Soung, A., Vollmer, L. L., Kanmogne, M., Last, A., Brown, J., & Klein, R. S. (2019) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsMosquito-borne diseases and control

Cited by 272

The blood-brain barrier, chemokines and multiple sclerosis

Holman, D. W., Klein, R. S., & Ransohoff, R. M. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Chemokine receptors and signalingBarrier Structure and Function Studies

Cited by 247

Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen

Santiago-Tirado, F. H., Onken, M. D., Cooper, J. A., Klein, R. S., & Doering, T. L. (2017) · mBio

Fungal Infections and StudiesBarrier Structure and Function Studies

Cited by 238

Infectious immunity in the central nervous system and brain function

Klein, R. S., Garber, C., & Howard, N. (2017) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsInfectious Encephalopathies and Encephalitis

Cited by 235

Detecting axon damage in spinal cord from a mouse model of multiple sclerosis

Kim, J. H., Budde, M. D., Liang, H.-F., Klein, R. S., Russell, J. H., Cross, A. H., & Song, S.-K. (2006) · Neurobiology of Disease

Advanced Neuroimaging Techniques and ApplicationsMultiple Sclerosis Research Studies

Cited by 235

Viral Pathogen-Associated Molecular Patterns Regulate Blood-Brain Barrier Integrity via Competing Innate Cytokine Signals

Daniels, B. P., Holman, D. W., Cruz-Orengo, L., Jujjavarapu, H., Durrant, D. M., & Klein, R. S. (2014) · mBio

Barrier Structure and Function Studiesinterferon and immune responses

Cited by 235

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier

Lazear, H. M., Daniels, B. P., Pinto, A. K., Huang, A. C., Vick, S. C., Doyle, S. E., Gale, M., Klein, R. S., & Diamond, M. S. (2015) · Science Translational Medicine

interferon and immune responsesBarrier Structure and Function Studies

Cited by 234

CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity

Cruz-Orengo, L., Holman, D. W., Dorsey, D., Zhou, L., Zhang, P., Wright, M., McCandless, E. E., Patel, J. R., Luker, G. D., Littman, D. R., et al. (2011) · Journal of Experimental Medicine

Chemokine receptors and signalingBarrier Structure and Function Studies

Cited by 231

CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination

Patel, J. R., McCandless, E. E., Dorsey, D., & Klein, R. S. (2010) · Proceedings of the National Academy of Sciences

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 231

Pathological Expression of CXCL12 at the Blood-Brain Barrier Correlates with Severity of Multiple Sclerosis

McCandless, E. E., Piccio, L., Woerner, B. M., Schmidt, R. E., Rubin, J. B., Cross, A. H., & Klein, R. S. (2008) · The American Journal of Pathology

Multiple Sclerosis Research StudiesChemokine receptors and signaling

Cited by 206

Neuroinflammation During RNA Viral Infections

Klein, R. S., Garber, C., Funk, K. E., Salimi, H., Soung, A., Kanmogne, M., Manivasagam, S., Agner, S., & Cain, M. (2019) · Annual Review of Immunology

Neuroinflammation and Neurodegeneration MechanismsInfectious Encephalopathies and Encephalitis

Cited by 160

CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis

Funk, K. E., & Klein, R. S. (2019) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsMosquito-borne diseases and control

Cited by 156

The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity

Miner, J. J., Daniels, B. P., Shrestha, B., Proenca-Modena, J. L., Lew, E. D., Lazear, H. M., Gorman, M. J., Lemke, G., Klein, R. S., & Diamond, M. S. (2015) · Nature Medicine

Phagocytosis and Immune RegulationBarrier Structure and Function Studies

Cited by 152

Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS

Patel, J. R., Williams, J. L., Muccigrosso, M. M., Liu, L., Sun, T., Rubin, J. B., & Klein, R. S. (2012) · Acta Neuropathologica

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 134

Immune and nervous system CXCL12 and CXCR4: parallel roles in patterning and plasticity

Klein, R. S., & Rubin, J. B. (2004) · Trends in Immunology

Chemokine receptors and signalingNeuroinflammation and Neurodegeneration Mechanisms

Cited by 132

Virus entry and replication in the brain precedes blood-brain barrier disruption during intranasal alphavirus infection

Cain, M. D., Salimi, H., Gong, Y., Yang, L., Hamilton, S. L., Heffernan, J. R., Hou, J., Miller, M. J., & Klein, R. S. (2017) · Journal of Neuroimmunology

Barrier Structure and Function StudiesMosquito-borne diseases and control

Cited by 86

Knocking on Closed Doors: Host Interferons Dynamically Regulate Blood-Brain Barrier Function during Viral Infections of the Central Nervous System

Daniels, B. P., & Klein, R. S. (2015) · PLOS Pathogens

Barrier Structure and Function Studiesinterferon and immune responses

Cited by 42

The multitaskers of the brain: glial responses to viral infections and associated post-infectious neurologic sequelae

Davé, V. A., & Klein, R. S. (2023) · Glia

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 29