Hardie, D. Grahame

AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer

Hardie, D. G. (2013) · Diabetes

Metabolism, Diabetes, and CancerNatural Antidiabetic Agents Studies

Cited by 458

The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor

McBride, A., Ghilagaber, S., Nikolaev, A., & Hardie, D. G. (2009) · Cell Metabolism

Metabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

Cited by 432

AMP ‐activated protein kinase: a cellular energy sensor that comes in 12 flavours

Ross, F. A., MacKintosh, C., & Hardie, D. G. (2016) · The FEBS Journal

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 381

Sensing of energy and nutrients by AMP-activated protein kinase

Hardie, D. G. (2011) · The American Journal of Clinical Nutrition

Metabolism, Diabetes, and CancerSirtuins and Resveratrol in Medicine

Cited by 372

AMP-Activated Protein Kinase: An Ultrasensitive System for Monitoring Cellular Energy Charge

HARDIE, D. G., SALT, I. P., HAWLEY, S. A., & DAVIES, S. P. (1999) · Biochemical Journal

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 362

Regulation of 5′AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle

Wojtaszewski, J. F. P., MacDonald, C., Nielsen, J. N., Hellsten, Y., Hardie, D. G., Kemp, B. E., Kiens, B., & Richter, E. A. (2003) · American Journal of Physiology-Endocrinology and Metabolism

Metabolism, Diabetes, and CancerMuscle metabolism and nutrition

Cited by 348

A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias

Hudson, E. R., Pan, D. A., James, J., Lucocq, J. M., Hawley, S. A., Green, K. A., Baba, O., Terashima, T., & Hardie, D. G. (2003) · Current Biology

Metabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

Cited by 332

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes

Tamás, P., Hawley, S. A., Clarke, R. G., Mustard, K. J., Green, K., Hardie, D. G., & Cantrell, D. A. (2006) · The Journal of Experimental Medicine

Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling

Cited by 328

Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase

MUNDAY, M. R., CAMPBELL, D. G., CARLING, D., & HARDIE, D. G. (1988) · European Journal of Biochemistry

Metabolism, Diabetes, and CancerCancer, Lipids, and Metabolism

Cited by 308

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

Sakamoto, K., Göransson, O., Hardie, D. G., & Alessi, D. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 299

AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels

Hardie, D. G. (2014) · Annual Review of Nutrition

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 281

AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels

Hardie, D. G., & Ashford, M. L. J. (2014) · Physiology

Metabolism, Diabetes, and CancerRegulation of Appetite and Obesity

Cited by 280

Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase

DAVIES, S. P., SIM, A. T. R., & HARDIE, D. G. (1990) · European Journal of Biochemistry

Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling

Cited by 274

Glycogen-Dependent Effects of 5-Aminoimidazole-4-Carboxamide (AICA)-Riboside on AMP-Activated Protein Kinase and Glycogen Synthase Activities in RatSkeletal Muscle

Wojtaszewski, J. F. P., Jørgensen, S. B., Hellsten, Y., Hardie, D. G., & Richter, E. A. (2002) · Diabetes

Metabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

Cited by 261

The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading

Jørgensen, S. B., Nielsen, J. N., Birk, J. B., Olsen, G. S., Viollet, B., Andreelli, F., Schjerling, P., Vaulont, S., Hardie, D. G., Hansen, B. F., et al. (2004) · Diabetes

Metabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

Cited by 241

5′-AMP-activated Protein Kinase Phosphorylates IRS-1 on Ser-789 in Mouse C2C12 Myotubes in Response to 5-Aminoimidazole-4-carboxamide Riboside

Jakobsen, S. N., Hardie, D. G., Morrice, N., & Tornqvist, H. E. (2001) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerNatural Antidiabetic Agents Studies

Cited by 238

Phosphorylation of rat muscle acetyl-coa carboxylase by amp-activated protein kinase and protein kinase A

Winder, W. W., Wilson, H. A., Hardie, D. G., Rasmussen, B. B., Hutber, C. A., Call, G. B., Clayton, R. D., Conley, L. M., Yoon, S., & Zhou, B. (1997) · Journal of Applied Physiology

Metabolism, Diabetes, and CancerPeroxisome Proliferator-Activated Receptors

Cited by 237

Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP‐activated protein kinase: A sensitive mechanism to protect the cell against ATP depletion

MOORE, F., WEEKES, J., & HARDIE, D. G. (1991) · European Journal of Biochemistry

Metabolism, Diabetes, and CancerPeroxisome Proliferator-Activated Receptors

Cited by 223

AMP-activated protein kinase: Also regulated by ADP?

Hardie, D. G., Carling, D., & Gamblin, S. J. (2011) · Trends in Biochemical Sciences

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 187

Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

Geraghty, K. M., Chen, S., Harthill, J. E., Ibrahim, A. F., Toth, R., Morrice, N. A., Vandermoere, F., Moorhead, G. B., Hardie, D. G., & MacKintosh, C. (2007) · Biochemical Journal

14-3-3 protein interactionsMetabolism, Diabetes, and Cancer

Cited by 181

Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms

Ross, F. A., Jensen, T. E., & Hardie, D. G. (2016) · Biochemical Journal

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 172

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

Pehmøller, C., Treebak, J. T., Birk, J. B., Chen, S., MacKintosh, C., Hardie, D. G., Richter, E. A., & Wojtaszewski, J. F. P. (2009) · American Journal of Physiology-Endocrinology and Metabolism

Metabolism, Diabetes, and CancerCellular transport and secretion

Cited by 171

AMP-activated protein kinase: a key system mediating metabolic responses to exercise

HARDIE, D. G. (2004) · Medicine & Science in Sports & Exercise

Metabolism, Diabetes, and CancerCardiovascular and exercise physiology

Cited by 165

5′-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle

Frøsig, C., Jørgensen, S. B., Hardie, D. G., Richter, E. A., & Wojtaszewski, J. F. P. (2004) · American Journal of Physiology-Endocrinology and Metabolism

Metabolism, Diabetes, and CancerCardiovascular and exercise physiology

Cited by 161