AMP-Activated Protein Kinase: An Ultrasensitive System for Monitoring Cellular Energy Charge

THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?

Hardie, D. G., Carling, D., & Carlson, M. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.821 · Cited by 1,436 · see citing works

The AMP‐Activated Protein Kinase: Fuel Gauge of the Mammalian Cell?

Hardie, D. G., & Carling, D. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00259.x · Cited by 1,317 · see citing works

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D., & Hardie, D. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27879 · Cited by 1,264 · see citing works

5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?

Corton, J. M., Gillespie, J. G., Hawley, S. A., & Hardie, D. G. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20498.x · Cited by 1,232 · see citing works

An amplified sensitivity arising from covalent modification in biological systems.

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Ultrasensitivity in the mitogen-activated protein kinase cascade.

Huang, C. Y., & Ferrell, J. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10078 · Cited by 1,186 · see citing works

The Biochemical Basis of an All-or-None Cell Fate Switch in <i>Xenopus</i> Oocytes

Ferrell, J. E., & Machleder, E. M. (1998) · Science · doi:10.1126/science.280.5365.895 · Cited by 1,052 · see citing works

AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle

Merrill, G. F., Kurth, E. J., Hardie, D. G., & Winder, W. W. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.6.e1107 · Cited by 1,027 · see citing works

Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise

Winder, W. W., & Hardie, D. G. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.2.e299 · Cited by 799 · see citing works

Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport

Hayashi, T., Hirshman, M. F., Kurth, E. J., Winder, W. W., & Goodyear, L. J. (1998) · Diabetes · doi:10.2337/diab.47.8.1369 · Cited by 774 · see citing works

Mammalian AMP-activated protein kinase subfamily

Stapleton, D., Mitchelhill, K. I., Gao, G., Widmer, J., Michell, B. J., Teh, T., House, C. M., Fernandez, C. S., Cox, T., Witters, L. A., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.2.611 · Cited by 652 · see citing works

5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2C <i>α</i> and native bovine protein phosphatase‐2A _c

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Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs

Ferrell, J. E. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)20026-x · Cited by 591 · see citing works

High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5’-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase

Kudo, N., Barr, A., Barr, R. L., Desai, S. S., & Lopaschuk, G. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17513 · Cited by 565 · see citing works

Amplification and Adaptation in Regulatory and Sensory Systems

Koshland, D. E., Goldbeter, A., & Stock, J. B. (1982) · Science · doi:10.1126/science.7089556 · Cited by 480 · see citing works

Diversity in function and regulation of MAP kinase pathways

BLUMER, K. J., & Johnson, G. L. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90147-3 · Cited by 465 · see citing works

5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms

Hawley, S. A., Selbert, M. A., Goldstein, E. G., Edelman, A. M., Carling, D., & Hardie, D. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27186 · Cited by 441 · see citing works

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

Salt, I. P., Celler, J. W., Hawley, S. A., Prescott, A. R., Woods, A., Carling, D., & Hardie, D. G. (1998) · Biochemical Journal · doi:10.1042/bj3340177 · Cited by 437 · see citing works

Tissue distribution of the AMP‐activated protein kinase, and lack of activation by cyclic‐AMP‐dependent protein kinase, studied using a specific and sensitive peptide assay

DAVIES, S. P., Carling, D., & Hardie, D. G. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb15185.x · Cited by 431 · see citing works

Role of the AMP-activated protein kinase in the cellular stress response

Corton, J. M., Gillespie, J. G., & Hardie, D. G. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00070-1 · Cited by 423 · see citing works

AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β cells, and may regulate insulin release

Salt, I. P., JOHNSON, G., Ashcroft, S. J. H., & Hardie, D. G. (1998) · Biochemical Journal · doi:10.1042/bj3350533 · Cited by 408 · see citing works

Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle

Vavvas, D., Apazidis, A., Saha, A. K., Gamble, J., Patel, A., Kemp, B. E., Witters, L. A., & Ruderman, N. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13255 · Cited by 395 · see citing works

Similar substrate recognition motifs for mammalian AMP‐activated protein kinase, higher plant HMG‐CoA reductase kinase‐A, yeast SNF1, and mammalian calmodulin‐dependent protein kinase I

Dale, S. J., Wilson, W. A., Edelman, A. M., & Hardie, D. G. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00172-6 · Cited by 324 · see citing works

Dual regulation of the AMP‐activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle

Ponticos, M., Lu, Q. L., Morgan, J. E., Hardie, D. G., Partridge, T. A., & Carling, D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1688 · Cited by 317 · see citing works

The α1 and α2 isoforms of the AMP‐activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro

Woods, A., Salt, I. P., Scott, J., Hardie, D. G., & Carling, D. (1996) · FEBS Letters · doi:10.1016/s0014-5793(96)01209-4 · Cited by 261 · see citing works

Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP‐activated protein kinase

Henin, N., Vincent, M. F., Gruber, H. E., & Berghe, G. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.7.7737463 · Cited by 251 · see citing works

Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase

Hutber, C. A., Hardie, D. G., & Winder, W. W. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.2.e262 · Cited by 229 · see citing works

Superiority of interconvertible enzyme cascades in metabolic regulation: Analysis of multicyclic systems

Chock, P. B., & Stadtman, E. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.7.2766 · Cited by 175 · see citing works

Purification of the AMP‐activated protein kinase on ATP‐γ‐Sepharose and analysis of its subunit structure

DAVIES, S. P., Hawley, S. A., Woods, A., Carling, D., Haystead, T., & Hardie, D. G. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb19001.x · Cited by 173 · see citing works

Quantification of information transfer via cellular signal transduction pathways

Kholodenko, B. Ν., Hoek, J. B., Westerhoff, H. V., & Brown, G. C. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01018-1 · Cited by 166 · see citing works

Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl-CoA carboxylase

Rasmussen, B. B., & Winder, W. W. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.4.1104 · Cited by 158 · see citing works

Control of Hepatic Fatty Acid Oxidation by 5′-AMP-Activated Protein Kinase Involves a Malonyl-CoA-Dependent and a Malonyl-CoA-Independent Mechanism

Velasco, G., Geelen, M. J. H., & Guzmán, M. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.9784 · Cited by 115 · see citing works

Stimulation of rat liver AMP-activated protein kinase by AMP analogues

Henin, N., Vincent, M. F., & Berghe, G. (1996) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(96)00021-9 · Cited by 100 · see citing works

Muscle glycogenolysis. Regulation of the cyclic interconversion of phosphorylase a and phosphorylase b

Meinke, M. H., & Edstrom, R. D. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52237-7 · Cited by 29 · see citing works

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.009 · Cited by 1,589 · see citing works

Metformin: An Old Drug for the Treatment of Diabetes But a New Drug for the Protection of the Endothelium

Kinaan, M., Ding, H., & Triggle, C. R. (2015) · Medical Principles and Practice · doi:10.1159/000381643 · Cited by 1,515 · see citing works

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

Towler, M. C., & Hardie, D. G. (2007) · Circulation Research · doi:10.1161/01.res.0000256090.42690.05 · Cited by 1,247 · see citing works

AMPK: Sensing Glucose as well as Cellular Energy Status

Lin, S., & Hardie, D. G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.009 · Cited by 1,195 · see citing works

The AMP-activated protein kinase pathway – new players upstream and downstream

Hardie, D. G. (2004) · Journal of Cell Science · doi:10.1242/jcs.01540 · Cited by 1,136 · see citing works

The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways

Fryer, L. G. D., Patel, A. P., & Carling, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202489200 · Cited by 1,030 · see citing works

Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status

Hardie, D. G. (2003) · Endocrinology · doi:10.1210/en.2003-0982 · Cited by 994 · see citing works

A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle

Mu, J., Brozinick, J. T., Valladares, O., Bucan, M., & Birnbaum, M. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00251-9 · Cited by 924 · see citing works

Management of cellular energy by the AMP‐activated protein kinase system

Hardie, D. G., Scott, J. W., Pan, D. A., & Hudson, E. R. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00560-x · Cited by 855 · see citing works

The Antianginal Drug Trimetazidine Shifts Cardiac Energy Metabolism From Fatty Acid Oxidation to Glucose Oxidation by Inhibiting Mitochondrial Long-Chain 3-Ketoacyl Coenzyme A Thiolase

Kantor, P. F., Lucien, A., Kozak, R., & Lopaschuk, G. D. (2000) · Circulation Research · doi:10.1161/01.res.86.5.580 · Cited by 817 · see citing works

AMP-Activated Protein Kinase – Development of the Energy Sensor Concept

Hardie, D. G., Hawley, S. A., & Scott, J. W. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108944 · Cited by 813 · see citing works

AMP‐activated protein kinase: the energy charge hypothesis revisited

Hardie, D. G., & Hawley, S. A. (2001) · BioEssays · doi:10.1002/bies.10009 · Cited by 784 · see citing works

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

Hawley, S. A., Ross, F. A., Chevtzoff, C., Green, K. A., Evans, A., Fogarty, S., Towler, M. C., Brown, L. J., Ogunbayo, O. A., Evans, A. M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.001 · Cited by 773 · see citing works

AMP-activated protein kinase: the current landscape for drug development

Steinberg, G. R., & Carling, D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0019-2 · Cited by 757 · see citing works

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

Glatz, J. F. C., Luiken, J. J. F. P., & Bonen, A. (2010) · Physiological Reviews · doi:10.1152/physrev.00003.2009 · Cited by 755 · see citing works

Hypoxic Pulmonary Vasoconstriction

Sylvester, J. T., Shimoda, L. A., Aaronson, P. I., & Ward, J. P. T. (2012) · Physiological Reviews · doi:10.1152/physrev.00041.2010 · Cited by 727 · see citing works

Resveratrol stimulates AMP kinase activity in neurons

Dasgupta, B., & Milbrandt, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610068104 · Cited by 723 · see citing works

AMPK: a key regulator of energy balance in the single cell and the whole organism

Hardie, D. G. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.116 · Cited by 705 · see citing works

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

Hawley, S. A., Gadalla, A. E., Olsen, G. S., & Hardie, D. G. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2420 · Cited by 696 · see citing works

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

Sanders, M. J., Grondin, P., Hegarty, B. D., Snowden, M. A., & Carling, D. (2007) · Biochemical Journal · doi:10.1042/bj20061520 · Cited by 667 · see citing works

Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

CHEUNG, P. C. F., SALT, I. P., DAVIES, S. P., HARDIE, D. G., & CARLING, D. (2000) · Biochemical Journal · doi:10.1042/bj3460659 · Cited by 637 · see citing works

The regulation of AMP-activated protein kinase by phosphorylation

STEIN, S. C., Woods, A., Jones, N. A., DAVISON, M. D., & Carling, D. (2000) · Biochemical Journal · doi:10.1042/bj3450437 · Cited by 605 · see citing works

Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle

Jørgensen, S. B., Viollet, B., Andreelli, F., Frøsig, C., Birk, J. B., Schjerling, P., Vaulont, S., Richter, E. A., & Wojtaszewski, J. F. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306205200 · Cited by 553 · see citing works

AMPK: A Key Sensor of Fuel and Energy Status in Skeletal Muscle

Hardie, D. G., & Sakamoto, K. (2006) · Physiology · doi:10.1152/physiol.00044.2005 · Cited by 519 · see citing works

A genetically encoded fluorescent reporter of ATP:ADP ratio

Berg, J., Hung, Y. P., & Yellen, G. (2009) · Nature Methods · doi:10.1038/nmeth.1288 · Cited by 481 · see citing works

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D., & Partridge, L. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.07.007 · Cited by 435 · see citing works

AMP-Activated Protein Kinase as a Drug Target

Hardie, D. G. (2006) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105304 · Cited by 405 · see citing works

Characterization of the Role of AMP-Activated Protein Kinase in the Regulation of Glucose-Activated Gene Expression Using Constitutively Active and Dominant Negative Forms of the Kinase

Woods, A., Azzout‐Marniche, D., Foretz, M., STEIN, S. C., Lemarchand, P., Ferré, P., Foufelle, F., & Carling, D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6704-6711.2000 · Cited by 404 · see citing works

5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.

Lochhead, P. A., Salt, I. P., Walker, K. S., Hardie, D. G., & Sutherland, C. D. (2000) · Diabetes · doi:10.2337/diabetes.49.6.896 · Cited by 391 · see citing works

AMPK inhibition in health and disease

Viollet, B., Horman, S., Leclerc, J., Lantier, L., Foretz, M., Billaud, M., Giri, S., & Andreelli, F. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2010.488215 · Cited by 383 · see citing works

Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle

Winder, W. W. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1017 · Cited by 375 · see citing works

Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis

Rutter, G. A., Xavier, G. D. S., & Leclerc, I. (2003) · Biochemical Journal · doi:10.1042/bj20030048 · Cited by 328 · see citing works

C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase*

Kim, E.-K., Miller, I., Aja, S., Landree, L. E., Pinn, M., Mcfadden, J., Kuhajda, F., Moran, T., & Ronnett, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402165200 · Cited by 302 · see citing works

The Regulation of AMP-Activated Protein Kinase by H2O2

Choi, S.-L., Kim, S.-J., Lee, K.-T., Kim, J., Mu, J., Birnbaum, M. J., Soo Kim, S., & Ha, J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5544 · Cited by 294 · see citing works

AMPK as a mediator of hormonal signalling

Lim, C. T., Kola, B., & Korbonits, M. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0063 · Cited by 298 · see citing works

Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle

Birk, J. B., & Wojtaszewski, J. F. P. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.120972 · Cited by 293 · see citing works

The regulation of AMP-activated protein kinase by upstream kinases

Carling, D., Sanders, M. J., & Woods, A. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.124 · Cited by 288 · see citing works

Seasonal Regulation of Reproduction in Mammals

Hazlerigg, D. G., & Simonneaux, V. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00034-x · Cited by 281 · see citing works

A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan

Mohammed, I., Hollenberg, M. D., Ding, H., & Triggle, C. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.718942 · Cited by 278 · see citing works

Cardiac Insulin-Resistance and Decreased Mitochondrial Energy Production Precede the Development of Systolic Heart Failure After Pressure-Overload Hypertrophy

Zhang, L., Jaswal, J. S., Ussher, J. R., Sankaralingam, S., Wagg, C. S., Zaugg, M., & Lopaschuk, G. D. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.000228 · Cited by 271 · see citing works

Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

Banko, M. R., Allen, J. J., Schaffer, B. E., Wilker, E., Tsou, P., White, J. L., Villén, J., Wang, B., Kim, S. R., Sakamoto, K., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.11.005 · Cited by 245 · see citing works

Mechanisms for Increased Glycolysis in the Hypertrophied Rat Heart

Nascimben, L., Ingwall, J. S., Lorell, B. H., Pinz, I. M., Schultz, V., Tornheim, K., & Tian, R. (2004) · Hypertension · doi:10.1161/01.hyp.0000144292.69599.0c · Cited by 242 · see citing works

Substrate Competition as a Source of Ultrasensitivity in the Inactivation of Wee1

Kim, S. Y., & Ferrell, J. E. (2007) · Cell · doi:10.1016/j.cell.2007.01.039 · Cited by 220 · see citing works

Ghrelin: a hormone regulating food intake and energy homeostasis

Gil‐Campos, M., Aguilera, C. M., Cañete, R., & Gil, Á. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061787 · Cited by 218 · see citing works

The role of interleukin‐6 in insulin resistance, body fat distribution and energy balance

Hoene, M., & Weigert, C. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2007.00410.x · Cited by 218 · see citing works

Ultrasensitivity part I: Michaelian responses and zero-order ultrasensitivity

Ferrell, J. E., & Ha, S. H. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.08.003 · Cited by 213 · see citing works

Thrombin Activates AMP-Activated Protein Kinase in Endothelial Cells via a Pathway Involving Ca2+/Calmodulin-Dependent Protein Kinase Kinase β

Stahmann, N., Woods, A., Carling, D., & Heller, R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00383-06 · Cited by 213 · see citing works

Pyruvate kinase: current status of regulatory and functional properties

Muñoz-Márquez, M. E., & Ponce‐Rivas, E. (2003) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(03)00081-2 · Cited by 209 · see citing works

Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression

Xavier, G. D. S., Leclerc, I., Salt, I. P., Doiron, B., Hardie, D. G., Kahn, A., & Rutter, G. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4023 · Cited by 203 · see citing works

Fungicidal Drugs Induce a Common Oxidative-Damage Cellular Death Pathway

Belenky, P., Camacho, D., & Collins, J. J. (2013) · Cell Reports · doi:10.1016/j.celrep.2012.12.021 · Cited by 199 · see citing works

Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells

Fryer, L. G. D., Foufelle, F., Barnes, K., Baldwin, S. A., Woods, A., & Carling, D. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3630167 · Cited by 198 · see citing works

Regulation of spinach SNF1‐related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5′‐AMP

Sugden, C., Crawford, R. M., Halford, N. G., & Hardie, D. G. (1999) · The Plant Journal · doi:10.1046/j.1365-313x.1999.00532.x · Cited by 195 · see citing works

Roles of AMP-activated Protein Kinase in Alzheimer’s Disease

Cai, Z., Yan, L., Li, K., Quazi, S. H., & Zhao, B. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8173-2 · Cited by 191 · see citing works

AMP-activated protein kinase: An energy sensor and survival mechanism in the reinstatement of metabolic homeostasis

Sharma, A., Anand, S. K., Singh, N., Dwivedi, U. N., & Kakkar, P. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113614 · Cited by 197 · see citing works

Keeping the home fires burning: AMP-activated protein kinase

Hardie, D. G. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0774 · Cited by 187 · see citing works

Ultrasensitive response motifs: basic amplifiers in molecular signalling networks

Zhang, Q., Bhattacharya, S., & Andersen, M. E. (2013) · Open Biology · doi:10.1098/rsob.130031 · Cited by 187 · see citing works

Stimulation of Glucose Transport by AMP-activated Protein Kinase via Activation of p38 Mitogen-activated Protein Kinase

Xi, X., Han, J., & Zhang, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102824200 · Cited by 182 · see citing works

Role of AMPKα2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle

Jørgensen, S. B., Treebak, J. T., Viollet, B., Schjerling, P., Vaulont, S., Wojtaszewski, J. F. P., & Richter, E. A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00243.2006 · Cited by 176 · see citing works

Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise

Coven, D. L., Hu, X., Cong, L., Bergeron, R., Shulman, G. I., Hardie, D. G., & Young, L. H. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00171.2003 · Cited by 174 · see citing works

Dissociation of AMP-activated protein kinase activation and glucose transport in contracting slow-twitch muscle.

Derave, W., Ai, H., Ihlemann, J., Witters, L. A., Kristiansen, S., Richter, E. A., & Ploug, T. (2000) · Diabetes · doi:10.2337/diabetes.49.8.1281 · Cited by 168 · see citing works

AMP-activated protein kinase: a key system mediating metabolic responses to exercise

HARDIE, D. G. (2004) · Medicine &amp; Science in Sports &amp; Exercise · doi:10.1249/01.mss.0000106171.38299.64 · Cited by 165 · see citing works

Intrasteric control of AMPK via the γ1 subunit AMP allosteric regulatory site

Adams, J., Chen, Z.-P., van Denderen, B. V., Morton, C., Parker, M. W., Witters, L. A., Stapleton, D., & Kemp, B. (2004) · Protein Science · doi:10.1110/ps.03340004 · Cited by 166 · see citing works

The CBS Domain: A Protein Module with an Emerging Prominent Role in Regulation

Baykov, A. A., Tuominen, H. K., & Lahti, R. (2011) · ACS Chemical Biology · doi:10.1021/cb200231c · Cited by 157 · see citing works

Physiological functions of peroxisome proliferator-activated receptor β

Neels, J. G., & Grimaldi, P. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00027.2013 · Cited by 161 · see citing works

Multiple Regulatory Layers of SREBP1/2 by SIRT6

Elhanati, S., Kanfi, Y., Varvak, A., Roichman, A., Carmel-Gross, I., Barth, S., Gibor, G., & Cohen, H. Y. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.006 · Cited by 155 · see citing works

Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells

Pang, T., Zhang, Z., Gu, M., Qiu, B., Yu, L.-F., Cao, P.-R., Shao, W., Su, M., Li, J.-Y., Nan, F., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710114200 · Cited by 154 · see citing works

Fatal Congenital Heart Glycogenosis Caused by a Recurrent Activating R531Q Mutation in the γ2-Subunit of AMP-Activated Protein Kinase (PRKAG2), Not by Phosphorylase Kinase Deficiency

Burwinkel, B., Scott, J. W., Bührer, C., van Landeghem, F. K. H., Cox, G. F., Wilson, C. J., Hardie, D. G., & Kilimann, M. W. (2005) · The American Journal of Human Genetics · doi:10.1086/430840 · Cited by 152 · see citing works

AMPK: a cellular energy sensor primarily regulated by AMP

Gowans, G. J., & Hardie, D. G. (2014) · Biochemical Society Transactions · doi:10.1042/bst20130244 · Cited by 149 · see citing works

AMP-activated Protein Kinase Mediates Carotid Body Excitation by Hypoxia

Wyatt, C. N., Mustard, K. J., Pearson, S. A., Dallas, M. L., Atkinson, L., Kumar, P., Peers, C., Hardie, D. G., & Evans, A. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608742200 · Cited by 150 · see citing works

5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle.

Nielsen, J., Mustard, K. J., Graham, D. A., Yu, H.-Y., MacDonald, C. S., Pilegaard, H., Goodyear, L., Hardie, D. G., Richter, E., & Wojtaszewski, J. (2003) · Journal of applied physiology · doi:10.1152/japplphysiol.00642.2002 · Cited by 160 · see citing works

Potential Role for AMP-Activated Protein Kinase in Hypoglycemia Sensing in the Ventromedial Hypothalamus

McCrimmon, R. J., Fan, X., Ding, Y., Zhu, W., Jacob, R. J., & Sherwin, R. S. (2004) · Diabetes · doi:10.2337/diabetes.53.8.1953 · Cited by 148 · see citing works

Nutrient sensing and metabolic decisions

Lindsley, J. E., & Rutter, J. P. (2004) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpc.2004.06.014 · Cited by 143 · see citing works

Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance

Wredenberg, A., Freyer, C., Sandström, M. E., Katz, A., Wibom, R., Westerblad, H., & Larsson, N.-G. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.029 · Cited by 141 · see citing works

Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles

Durante, P. E., Mustard, K. J., Park, S.-H., Winder, W. W., & Hardie, D. G. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00404.2001 · Cited by 137 · see citing works

Expression of the AMP‐activated protein kinase β1 and β2 subunits in skeletal muscle

Chen, Z., Heierhorst, J., Mann, R. J., Mitchelhill, K. I., Michell, B. J., Witters, L. A., Lynch, G. S., Kemp, B. E., & Stapleton, D. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01371-x · Cited by 134 · see citing works

Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation

Bézaire, V., Spriet, L. L., Campbell, S., Sabet, N., Gerrits, M. F., Bonen, A., & Harper, M. (2005) · The FASEB Journal · doi:10.1096/fj.04-2765fje · Cited by 132 · see citing works

5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes.

Salt, I. P., Connell, J. M. C., & Gould, G. W. (2000) · Diabetes · doi:10.2337/diabetes.49.10.1649 · Cited by 132 · see citing works

AMP-activated Protein Kinase Inhibits Transforming Growth Factor-β-induced Smad3-dependent Transcription and Myofibroblast Transdifferentiation

Mishra, R., Cool, B. L., Laderoute, K. R., Foretz, M., Viollet, B., & Simonson, M. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800902200 · Cited by 128 · see citing works

Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations

Gruzman, A., Babai-Shani, G., & Sasson, S. (2009) · The Review of Diabetic Studies · doi:10.1900/rds.2009.6.13 · Cited by 128 · see citing works

AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells.

Krawiec, B., Nystrom, G. J., Frost, R., Jefferson, L., & Lang, C. H. (2007) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00622.2006 · Cited by 129 · see citing works

Functional Analysis of Mutations in the γ2 Subunit of AMP-activated Protein Kinase Associated with Cardiac Hypertrophy and Wolff-Parkinson-White Syndrome

Daniel, T. D., & Carling, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207093200 · Cited by 120 · see citing works

Ischaemic Preconditioning Protects Against Ischaemia/Reperfusion Injury: Emerging Concepts

Pasupathy, S., & Homer‐Vanniasinkam, S. (2004) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2004.11.005 · Cited by 118 · see citing works

Protection of Epithelial Barrier Function by the Crohn's Disease Associated Gene Protein Tyrosine Phosphatase N2

Scharl, M. M., Paul, G., Weber, A., Jung, B., Docherty, M. J., Hausmann, M., Rogler, G., Barrett, K. E., & McCole, D. F. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.078 · Cited by 116 · see citing works

AMP-Activated Protein Kinase: A Master Switch in Glucose and Lipid Metabolism

Hardie, D. G. (2004) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/b:remd.0000021433.63915.bb · Cited by 115 · see citing works

Activation of AMP-Activated Protein Kinase Within the Ventromedial Hypothalamus Amplifies Counterregulatory Hormone Responses in Rats With Defective Counterregulation

McCrimmon, R. J., Fan, X., Cheng, H. M., McNay, E. C., Chan, O. T. M., Shaw, M., Ding, Y., Zhu, W., & Sherwin, R. S. (2006) · Diabetes · doi:10.2337/db05-1359 · Cited by 112 · see citing works

Tau and mTOR: The Hotspots for Multifarious Diseases in Alzheimer's Development

Mueed, Z., Tandon, P., Maurya, S. K., Deval, R., Kamal, M. A., & Poddar, N. K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.01017 · Cited by 111 · see citing works

AMP-activated Protein Kinase Mediates the Interferon-γ-induced Decrease in Intestinal Epithelial Barrier Function

Scharl, M. M., Paul, G., Barrett, K. E., & McCole, D. F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.046292 · Cited by 110 · see citing works

Neither LKB1 Nor AMPK Are the Direct Targets of Metformin

Hardie, D. G. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.07.032 · Cited by 111 · see citing works

Global Phosphoproteome of HT-29 Human Colon Adenocarcinoma Cells

Kim, J., Tannenbaum, S. R., & White, F. M. (2005) · Journal of Proteome Research · doi:10.1021/pr050048h · Cited by 110 · see citing works

A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion

Pan, D. A., & Hardie, D. G. (2002) · Biochemical Journal · doi:10.1042/bj20020703 · Cited by 108 · see citing works

Dual Mechanisms Regulating AMPK Kinase Action in the Ischemic Heart

Baron, S. J., Li, J., Russell, R. R., Neumann, D., Miller, E. J., Tuerk, R. D., Wallimann, T., Hurley, R. L., Witters, L. A., & Young, L. H. (2005) · Circulation Research · doi:10.1161/01.res.0000155723.53868.d2 · Cited by 108 · see citing works

Ppm1E is an in cellulo AMP-activated protein kinase phosphatase

Voß, M., Paterson, J., Kelsall, I. R., Martín‐Granados, C., Hastie, C. J., Peggie, M. W., & Cohen, P. T. W. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.08.010 · Cited by 106 · see citing works

A Potential Role for AMP-Activated Protein Kinase in Meiotic Induction in Mouse Oocytes

Downs, S. M., Hudson, E. R., & Hardie, D. G. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0613 · Cited by 107 · see citing works

Hepatic energy state is regulated by glucagon receptor signaling in mice

Berglund, E. D., Lee, R. S., Lustig, D. G., Lynes, S. E., Donahue, E. P., Camacho, R. C., Meredith, M. E., Magnuson, M. A., Charron, M. J., & Wasserman, D. H. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38650 · Cited by 106 · see citing works

Genome-Based Metabolic Mapping and 13C Flux Analysis Reveal Systematic Properties of an Oleaginous Microalga <i>Chlorella protothecoides</i>

Wu, C., Xiong, W., Dai, J., & Wu, Q. (2015) · Plant Physiology · doi:10.1104/pp.114.250688 · Cited by 99 · see citing works

The Relationship between AMP-activated Protein Kinase Activity and AMP Concentration in the Isolated Perfused Rat Heart

Frederich, M., & Balschi, J. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107128200 · Cited by 105 · see citing works

AMP-activated protein kinase and human cancer: cancer metabolism revisited

Kuhajda, F. P. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.121 · Cited by 102 · see citing works

AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity

Lee, J.-W., Choe, S. S., Jang, H., Kim, J., Jeong, H. W., Jo, H., Jeong, K.-H., Tadi, S., Park, M. G., Kwak, T. H., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m022897 · Cited by 101 · see citing works

AMP-activated protein kinase (AMPK) in the rock crab, Cancer irroratus : an early indicator of temperature stress

Frederich, M., O'Rourke, M., Furey, N. B., & Jost, J. A. (2009) · Journal of Experimental Biology · doi:10.1242/jeb.021998 · Cited by 99 · see citing works

AMP-activated protein kinase: nature's energy sensor

Carling, D., Mayer, F. V., Sanders, M. J., & Gamblin, S. J. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.610 · Cited by 416 · see citing works

Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/en.2003-0982 Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status

Hardie, D. G. (2013)

AMP-activated protein kinase - the key sensor of cellular energy charge

Hardie, D. G. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(01)90559-0 · Cited by 1 · see citing works

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer

Lecture, N. M. (2011)

AMP‐activated protein kinase: the energy charge hypothesis revisited

Hardie, D. G., & Hawley, S. A. (2001) · BioEssays · doi:10.1002/bies.10009 · Cited by 784 · see citing works