Willnow, Thomas E.

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

Rogaeva, E., Meng, Y., Lee, J. H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C. T., Cheng, R., Hasegawa, H., et al. (2007) · Nature Genetics

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 1,167

Sortilin is essential for proNGF-induced neuronal cell death

Nykjaer, A., Lee, R., Teng, K. K., Jansen, P., Madsen, P., Nielsen, M. S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T. E., et al. (2004) · Nature

Nerve injury and regenerationCell death mechanisms and regulation

Cited by 962

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

Andersen, O. M., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., von Arnim, C. A. F., Breiderhoff, T., Jansen, P., Wu, X., et al. (2005) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 655

Role of Endocytosis in Cellular Uptake of Sex Steroids

Hammes, A., Andreassen, T. K., Spoelgen, R., Raila, J., Hubner, N., Schulz, H., Metzger, J., Schweigert, F. J., Luppa, P. B., Nykjaer, A., et al. (2005) · Cell

Estrogen and related hormone effectsHormonal and reproductive studies

Cited by 413

P75NTR-live or let die

Nykjaer, A., Willnow, T. E., & Petersen, C. M. (2005) · Current Opinion in Neurobiology

Nerve injury and regenerationCell death mechanisms and regulation

Cited by 318

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors

Willnow, T. E., Rohlmann, A., Horton, J., Otani, H., Braun, J. R., Hammer, R. E., & Herz, J. (1996) · The EMBO Journal

Cholesterol and Lipid MetabolismHeat shock proteins research

Cited by 276

Single-Cell Transcriptomics Characterizes Cell Types in the Subventricular Zone and Uncovers Molecular Defects Impairing Adult Neurogenesis

Zywitza, V., Misios, A., Bunatyan, L., Willnow, T. E., & Rajewsky, N. (2018) · Cell Reports

Neurogenesis and neuroplasticity mechanismsSingle-cell and spatial transcriptomics

Cited by 183

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Schmidt, V., Sporbert, A., Rohe, M., Reimer, T., Rehm, A., Andersen, O. M., & Willnow, T. E. (2007) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 181

Molecular Dissection of the Interaction between Amyloid Precursor Protein and Its Neuronal Trafficking Receptor SorLA/LR11

Andersen, O. M., Schmidt, V., Spoelgen, R., Gliemann, J., Behlke, J., Galatis, D., McKinstry, W. J., Parker, M. W., Masters, C. L., Hyman, B. T., et al. (2006) · Biochemistry

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 178

Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System

Malik, A. R., & Willnow, T. E. (2019) · International Journal of Molecular Sciences

Amino Acid Enzymes and MetabolismNeuroscience and Neuropharmacology Research

Cited by 170

Loss of LR11/SORLA Enhances Early Pathology in a Mouse Model of Amyloidosis: Evidence for a Proximal Role in Alzheimer's Disease

Dodson, S. E., Andersen, O. M., Karmali, V., Fritz, J. J., Cheng, D., Peng, J., Levey, A. I., Willnow, T. E., & Lah, J. J. (2008) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 141

Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs

Meyer, K., Kirchner, M., Uyar, B., Cheng, J.-Y., Russo, G., Hernandez-Miranda, L. R., Szymborska, A., Zauber, H., Rudolph, I.-M., Willnow, T. E., et al. (2018) · Cell

Protein Structure and DynamicsCellular transport and secretion

Cited by 132

Sorting receptor SORLA – a trafficking path to avoid Alzheimer disease

Willnow, T. E., & Andersen, O. M. (2013) · Journal of Cell Science

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 121

The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain

Carlo, A.-S., Gustafsen, C., Mastrobuoni, G., Nielsen, M. S., Burgert, T., Hartl, D., Rohe, M., Nykjaer, A., Herz, J., Heeren, J., et al. (2013) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 117

Essential Role of the Apolipoprotein E Receptor-2 in Sperm Development

Andersen, O. M., Yeung, C.-H., Vorum, H., Wellner, M., Andreassen, T. K., Erdmann, B., Mueller, E.-C., Herz, J., Otto, A., Cooper, T. G., et al. (2003) · Journal of Biological Chemistry

Sperm and Testicular FunctionReproductive Biology and Fertility

Cited by 112

Lipoprotein and receptor interactions in vivo

Herz, J., & Willnow, T. E. (1995) · Current Opinion in Lipidology

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 88

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

Schmidt, V., Baum, K., Lao, A., Rateitschak, K., Schmitz, Y., Teichmann, A., Wiesner, B., Petersen, C. M., Nykjaer, A., Wolf, J., et al. (2012) · The EMBO Journal

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 75

SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein

Huang, T. Y., Zhao, Y., Li, X., Wang, X., Tseng, I.-C., Thompson, R., Tu, S., Willnow, T. E., Zhang, Y.-W., & Xu, H. (2016) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 69

Differential Binding of Ligands to the Apolipoprotein E Receptor 2

Andersen, O. M., Benhayon, D., Curran, T., & Willnow, T. E. (2003) · Biochemistry

Axon Guidance and Neuronal SignalingDevelopmental Biology and Gene Regulation

Cited by 67

Sorting receptor SORLA: cellular mechanisms and implications for disease

Schmidt, V., Subkhangulova, A., & Willnow, T. E. (2017) · Cellular and Molecular Life Sciences

Cellular transport and secretionAlzheimer's disease research and treatments

Cited by 65

SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration

Huang, T. Y., Zhao, Y., Jiang, L.-L., Li, X., Liu, Y., Sun, Y., Piña-Crespo, J. C., Zhu, B., Masliah, E., Willnow, T. E., et al. (2017) · Journal of Experimental Medicine

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 50

Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel

Greda, A. K., Gomes, J. P., Schmidt-Krueger, V., Zurawska-Plaksej, E., Fritsche-Guenther, R., Rudolph, I.-M., Telugu, N. S., Cömert, C., Kirwan, J., Kunz, S., et al. (2025) · Nature Metabolism

Alzheimer's disease research and treatmentsFatty Acid Research and Health

Cited by 21