Lipoprotein and receptor interactions in vivo
Abstract
A substantial number of animal models aimed at the genetic dissection of lipid metabolism have been generated recently. Transgenic and knockout mice, in which the receptors or apolipoproteins are overexpressed or destroyed, combined with virus-mediated gene transfer in vivo have advanced our understanding of the complex physiological and pathophysiological processes involved in lipid metabolism, including hepatic lipoprotein uptake and the formation of atherosclerotic lesions.
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LDL biology is mostly relevant for peripheral diseases.
“While LDL biology is mostly relevant for peripheral diseases32,54,55”
From Decreased lipidated ApoE‐receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes (2025) · cites this paper as [55]
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Mahley, R. W., & Ji, Z.-S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33334-4 · Cited by 693 · see citing works
Mahley, R. W., Huang, Y., & Rall, S. C. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32417-2 · Cited by 447 · see citing works
Mahley, R. W., & Huang, Y. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30889 · Cited by 159 · see citing works
Cohn, J. S., Marcoux, C., & Davignon, J. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.10.2474 · Cited by 156 · see citing works
Grehan, S., Tse, E., & Taylor, J. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00812.2001 · Cited by 138 · see citing works
Guo, J. L., Braun, D., Fitzgerald, G. A., Hsieh, Y.-T., Rougé, L., Litvinchuk, A., Steffek, M., Propson, N. E., Heffner, C. M., Discenza, C., et al. (2025) · Cell · doi:10.1016/j.cell.2024.10.027 · Cited by 91 · see citing works
“53 While LDL biology is mostly relevant for peripheral diseases, 32,54,55 the CNS primarily contains HDL-like particles, many of which harbor ApoE and can thus engage LDLR. 56 LDLR’s ligands in the CNS, besides ApoE, are not well defined.”
Georgiadou, D., Stamatakis, K., Efthimiadou, E. K., Kordas, G., Gantz, D., Chroni, A., & Stratikos, E. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m030965 · Cited by 37 · see citing works
Vezeridis, A. M., Drosatos, K., & Zannis, V. I. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m008409 · Cited by 11 · see citing works
Role of chondroitin sulphate in the uptake of β‐VLDL by brain cells
Rapp, A., & Hüttinger, M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04313.x · Cited by 4 · see citing works
Fotakis, P., Vezeridis, A., Dafnis, I., Chroni, A., Kardassis, D., & Zannis, V. I. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m048348 · Cited by 4 · see citing works
- Authors
- Herz, J., & Willnow, T. E.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Current Opinion in Lipidology
- Published
- 1995-04
- Volume
- 6
- Issue
- 2
- Pages
- 97-103
- ISSN
- 0957-9672 (ISSN-L)
- OpenAlex
- W2092658615
- Cited by
- 88
- References
- 0
- Citations by year
- 2024: 1 · 2016: 2 · 2014: 5 · 2013: 2 · 2012: 4
- FWCI
- 9.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Lipidology (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-20948, P01HL020948)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- lipid metabolism, transgenic mice, knockout mice, apolipoproteins, viral gene delivery, hepatic lipoprotein uptake, atherosclerosis, atherosclerotic lesion formation
- MeSH terms
- Animals, Apolipoproteins E, Humans, Lipoproteins, Mice, Transgenic, Proteoglycans, Receptors, LDL, Receptors, Lipoprotein, Mice, Knockout, Mice
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