Harper, J. Wade

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

Wei, W., Jin, J., Schlisio, S., Harper, J. W., & Kaelin, W. G. (2005) · Cancer Cell

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 403

Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

Guièze, R., Liu, V. M., Rosebrock, D., Jourdain, A. A., Hernández-Sánchez, M., Martinez Zurita, A., Sun, J., Ten Hacken, E., Baranowski, K., Thompson, P. A., et al. (2019) · Cancer Cell

Cell death mechanisms and regulationChronic Lymphocytic Leukemia Research

Cited by 361

Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex

Lin, D. I., Barbash, O., Kumar, K. G. S., Weber, J. D., Harper, J. W., Klein-Szanto, A. J. P., Rustgi, A., Fuchs, S. Y., & Diehl, J. A. (2006) · Molecular Cell

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 349

SCFβ-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

Jin, J., Shirogane, T., Xu, L., Nalepa, G., Qin, J., Elledge, S. J., & Harper, J. W. (2003) · Genes & Development

Ubiquitin and proteasome pathwaysDNA Repair Mechanisms

Cited by 340

Building and remodelling Cullin–RING E3 ubiquitin ligases

Lydeard, J. R., Schulman, B. A., & Harper, J. W. (2013) · The EMBO Reports

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 327

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

Pickrell, A. M., Huang, C.-H., Kennedy, S. R., Ordureau, A., Sideris, D. P., Hoekstra, J. G., Harper, J. W., & Youle, R. J. (2015) · Neuron

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 327

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

Biancur, D. E., Paulo, J. A., Małachowska, B., Quiles Del Rey, M., Sousa, C. M., Wang, X., Sohn, A. S. W., Chu, G. C., Gygi, S. P., Harper, J. W., et al. (2017) · Nature Communications

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 315

SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

Westbrook, T. F., Hu, G., Ang, X. L., Mulligan, P., Pavlova, N. N., Liang, A., Leng, Y., Maehr, R., Shi, Y., Harper, J. W., et al. (2008) · Nature

Ubiquitin and proteasome pathwaysDevelopmental Biology and Gene Regulation

Cited by 311

Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy

Ordureau, A., Heo, J.-M., Duda, D. M., Paulo, J. A., Olszewski, J. L., Yanishevski, D., Rinehart, J., Schulman, B. A., & Harper, J. W. (2015) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 310

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

Piccolis, M., Bond, L. M., Kampmann, M., Pulimeno, P., Chitraju, C., Jayson, C. B. K., Vaites, L. P., Boland, S., Lai, Z. W., Gabriel, K. R., et al. (2019) · Molecular Cell

Lipid metabolism and biosynthesisCancer, Lipids, and Metabolism

Cited by 269

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

Scott, D. C., Rhee, D. Y., Duda, D. M., Kelsall, I. R., Olszewski, J. L., Paulo, J. A., de Jong, A., Ovaa, H., Alpi, A. F., Harper, J. W., et al. (2016) · Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 229

DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation

Dango, S., Mosammaparast, N., Sowa, M. E., Xiong, L.-J., Wu, F., Park, K., Rubin, M., Gygi, S., Harper, J. W., & Shi, Y. (2011) · Molecular Cell

DNA Repair MechanismsEpigenetics and DNA Methylation

Cited by 216

Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8

Scott, D. C., Sviderskiy, V. O., Monda, J. K., Lydeard, J. R., Cho, S. E., Harper, J. W., & Schulman, B. A. (2014) · Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 201

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

Heo, J.-M., Ordureau, A., Swarup, S., Paulo, J. A., Shen, K., Sabatini, D. M., & Harper, J. W. (2018) · Science Advances

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Cited by 199

Comprehensive Analysis of Host Cellular Interactions with Human Papillomavirus E6 Proteins Identifies New E6 Binding Partners and Reflects Viral Diversity

White, E. A., Kramer, R. E., Tan, M. J. A., Hayes, S. D., Harper, J. W., & Howley, P. M. (2012) · Journal of Virology

Cervical Cancer and HPV ResearchCancer-related Molecular Pathways

Cited by 198

Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses

White, E. A., Sowa, M. E., Tan, M. J. A., Jeudy, S., Hayes, S. D., Santha, S., Münger, K., Harper, J. W., & Howley, P. M. (2012) · Proceedings of the National Academy of Sciences

Cervical Cancer and HPV ResearchUbiquitin and proteasome pathways

Cited by 198

Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy

An, H., & Harper, J. W. (2018) · Nature Cell Biology

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 181

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

Zhang, W., Wu, K.-P., Sartori, M. A., Kamadurai, H. B., Ordureau, A., Jiang, C., Mercredi, P. Y., Murchie, R., Hu, J., Persaud, A., et al. (2016) · Molecular Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 168

Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling

Tan, M. J. A., White, E. A., Sowa, M. E., Harper, J. W., Aster, J. C., & Howley, P. M. (2012) · Proceedings of the National Academy of Sciences

Cervical Cancer and HPV ResearchDevelopmental Biology and Gene Regulation

Cited by 132

A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability

O'Connell, B. C., Adamson, B., Lydeard, J. R., Sowa, M. E., Ciccia, A., Bredemeyer, A. L., Schlabach, M., Gygi, S. P., Elledge, S. J., & Harper, J. W. (2010) · Molecular Cell

DNA Repair MechanismsCancer therapeutics and mechanisms

Cited by 122

Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells

Brennan, C. M., Vaites, L. P., Wells, J. N., Santaguida, S., Paulo, J. A., Storchova, Z., Harper, J. W., Marsh, J. A., & Amon, A. (2019) · Genes & Development

Microtubule and mitosis dynamicsHeat shock proteins research

Cited by 109

Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis

Boland, S., Swarup, S., Ambaw, Y. A., Malia, P. C., Richards, R. C., Fischer, A. W., Singh, S., Aggarwal, G., Spina, S., Nana, A. L., et al. (2022) · Nature Communications

Lysosomal Storage Disorders ResearchGlycogen Storage Diseases and Myoclonus

Cited by 97

A multi-scale map of cell structure fusing protein images and interactions

Qin, Y., Huttlin, E. L., Winsnes, C. F., Gosztyla, M. L., Wacheul, L., Kelly, M. R., Blue, S. M., Zheng, F., Chen, M., Schaffer, L. V., et al. (2021) · Nature

Bioinformatics and Genomic NetworksAdvanced Proteomics Techniques and Applications

Cited by 82

Visualizing chaperone-mediated multistep assembly of the human 20S proteasome

Adolf, F., Du, J., Goodall, E. A., Walsh, R. M., Rawson, S., von Gronau, S., Harper, J. W., Hanna, J., & Schulman, B. A. (2024) · Nature Structural & Molecular Biology

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 33