Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells
Open accessAbstract
Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein aggregation. Here, we identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. Subunits of protein complexes encoded on excess chromosomes aggregate in aneuploid cells, which is suppressed when expression of other subunits is coordinately altered. We further show that excess subunits are either degraded or aggregate and that protein aggregation is nearly as effective as protein degradation at lowering levels of excess proteins. Our study explains why proteotoxic stress is a universal feature of the aneuploid state and reveals protein aggregation as a form of dosage compensation to cope with disproportionate expression of protein complex subunits.
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The reduction of Exo9 and EXOSC10 protein abundance across all subunits is caused by orphan protein decay because of the increased production of the unstable, and likely unusable, short EXOSC3 proteoform.
“We conclude that the reduction of Exo9 and EXOSC10 protein abundance across all subunits is caused by orphan protein decay because of the increased production of the unstable, and likely unusable, short EXOSC3 proteoform107–109.”
From EXOSC3 G191 Variants Trigger System-Wide Recalibration of RNA Processing Machinery (2026) · cites this paper as [108]
The Results section (‘Excess proteins either aggregate or are degraded’; page unavailable) reports that excess protein-complex subunits can be degraded, and the Discussion describes imbalances that leave subunits without binding partners. The paper does not address Exo9, EXOSC10, or a short EXOSC3 proteoform, so it does not establish the claimed cause of their reduced abundance. (LLM, conf=0.84)
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Dual contributions of Xrp1 to genome integrity through the DNA damage response and cell competition
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Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer
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Consequences of mitotic failure – The penalties and the rewards
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When Down Is Up: Heterochromatin, Nuclear Organization and X Upregulation
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Characterizing chromosomal instability-driven cancer evolution and cell fitness at a glance
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Aneuploidy-induced cellular behaviors: Insights from Drosophila
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A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancerPreprint
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EXOSC3 G191 Variants Trigger System-Wide Recalibration of RNA Processing Machinery
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Energetics of whole genome doubling and genomic instability
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Complex networks of miRNA-transcription factors mediate gene dosage compensation in aneuploid cancerPreprint
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- Authors
- Brennan, C. M., Vaites, L. P., Wells, J. N., Santaguida, S., Paulo, J. A., Storchova, Z., Harper, J. W., Marsh, J. A., & Amon, A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- Western General Hospital (GB)
- ORCID
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2019-06-13
- Volume
- 33
- Issue
- 15-16
- Pages
- 1031-1047
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC6672052
- OpenAlex
- W2953356987
- Cited by
- 109
- References
- 42
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 16 · 2023: 14 · 2022: 14 · 2021: 18 · 2020: 19 · 2019: 3
- Type
- posted content
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Genes & Development (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (acceptedVersion, other-oa)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health (CA206157, GM118066)
- Medical Research Council Career Development Award (MR/M02122X/1)
- American Italian Cancer Foundation
- Marie Curie Actions
- Italian Association for Cancer Research
- Koch Institute Quinquennial Cancer Research Fellowship
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- aneuploidy, protein aggregation, protein complex stoichiometry, proteotoxic stress, dosage compensation, protein degradation
- MeSH terms
- Aneuploidy, Cytosol, Dosage Compensation, Genetic, Humans, Saccharomyces cerevisiae, Protein Subunits, Saccharomyces cerevisiae Proteins, Multiprotein Complexes, Proteolysis, Protein Aggregation, Pathological, Protein Aggregates
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