Colburn, Nancy H.

MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

Asangani, I. A., Rasheed, S. A. K., Nikolova, D. A., Leupold, J. H., Colburn, N. H., Post, S., & Allgayer, H. (2008) · Oncogene

MicroRNA in disease regulationCancer-related molecular mechanisms research

Cited by 1,882

S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth

Dorrello, N. V., Peschiaroli, A., Guardavaccaro, D., Colburn, N. H., Sherman, N. E., & Pagano, M. (2006) · Science

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 731

MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene

Lu, Z., Liu, M., Stribinskis, V, Klinge, C. M., Ramos, K. S., Colburn, N. H., & Li, Y. (2008) · Oncogene

MicroRNA in disease regulationCancer-related molecular mechanisms research

Cited by 711

The Transformation Suppressor Pdcd4 Is a Novel Eukaryotic Translation Initiation Factor 4A Binding Protein That Inhibits Translation

Yang, H.-S., Jansen, A. P., Komar, A. A., Zheng, X., Merrick, W. C., Costes, S., Lockett, S. J., Sonenberg, N., & Colburn, N. H. (2003) · Molecular and Cellular Biology

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 494

Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.

Dong, Z., Birrer, M. J., Watts, R. G., Matrisian, L. M., & Colburn, N. H. (1994) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCarcinogens and Genotoxicity Assessment

Cited by 386

Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation

Cmarik, J. L., Min, H., Hegamyer, G., Zhan, S., Kulesz-Martin, M., Yoshinaga, H., Matsuhashi, S., & Colburn, N. H. (1999) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysMechanisms of cancer metastasis

Cited by 254

p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase

Zhao, Y., Chaiswing, L., Velez, J. M., Batinic-Haberle, I., Colburn, N. H., Oberley, T. D., & St. Clair, D. K. (2005) · Cancer Research

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 245

Epidermal Expression of the Translation Inhibitor Programmed Cell Death 4 Suppresses Tumorigenesis

Jansen, A. P., Camalier, C. E., & Colburn, N. H. (2005) · Cancer Research

Cancer-related Molecular PathwaysRNA and protein synthesis mechanisms

Cited by 212

AP1/ jun Function Is Differentially Induced in Promotion-Sensitive and Resistant JB6 Cells

Bernstein, L. R., & Colburn, N. H. (1989) · Science

Protein Kinase Regulation and GTPase SignalingCarcinogens and Genotoxicity Assessment

Cited by 207

Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression to Suppress Colon Carcinoma Cell Invasion

Yang, H.-S., Matthews, C. P., Clair, T., Wang, Q., Baker, A. R., Li, C.-C. H., Tan, T.-H., & Colburn, N. H. (2006) · Molecular and Cellular Biology

Mechanisms of cancer metastasisProtein Kinase Regulation and GTPase Signaling

Cited by 202

A Novel Function of the MA-3 Domains in Transformation and Translation Suppressor Pdcd4 Is Essential for Its Binding to Eukaryotic Translation Initiation Factor 4A

Yang, H.-S., Cho, M.-H., Zakowicz, H., Hegamyer, G., Sonenberg, N., & Colburn, N. H. (2004) · Molecular and Cellular Biology

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 199

Loss of programmed cell death 4 expression marks adenoma‐carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer

Mudduluru, G., Medved, F., Grobholz, R., Jost, C., Gruber, A., Leupold, J. H., Post, S., Jansen, A., Colburn, N. H., & Allgayer, H. (2007) · Cancer

Cell death mechanisms and regulationGenetic factors in colorectal cancer

Cited by 196

A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-κB or ODC transactivation

Yang, H.-S., Jansen, A. P., Nair, R., Shibahara, K., Verma, A. K., Cmarik, J. L., & Colburn, N. H. (2001) · Oncogene

Mechanisms of cancer metastasisCancer-related Molecular Pathways

Cited by 185

Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo

Gaur, A. B., Holbeck, S. L., Colburn, N. H., & Israel, M. A. (2011) · Neuro-Oncology

MicroRNA in disease regulationCancer-related molecular mechanisms research

Cited by 180

Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors

Leupold, J. H., Yang, H.-S., Colburn, N. H., Asangani, I., Post, S., & Allgayer, H. (2007) · Oncogene

Protease and Inhibitor MechanismsMechanisms of cancer metastasis

Cited by 163

Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation

Yang, H.-S., Knies, J. L., Stark, C., & Colburn, N. H. (2003) · Oncogene

Cancer-related Molecular PathwaysMechanisms of cancer metastasis

Cited by 160

Translation Inhibitor Pdcd4 Is Targeted for Degradation during Tumor Promotion

Schmid, T., Jansen, A. P., Baker, A. R., Hegamyer, G., Hagan, J. P., & Colburn, N. H. (2008) · Cancer Research

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 151

Characterization of programmed cell death 4 in multiple human cancers reveals a novel enhancer of drug sensitivity

Jansen, A. P., Camalier, C. E., Stark, C., & Colburn, N. H. (2004) · Molecular Cancer Therapeutics

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 132

Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma

Wang, Q., Zhu, J., Wang, Y.-W., Dai, Y., Wang, Y.-L., Wang, C., Liu, J., Baker, A., Colburn, N. H., & Yang, H.-S. (2017) · Oncogene

PI3K/AKT/mTOR signaling in cancerMechanisms of cancer metastasis

Cited by 67

Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion

Santhanam, A. N., Baker, A. R., Hegamyer, G., Kirschmann, D. A., & Colburn, N. H. (2010) · Oncogene

Mechanisms of cancer metastasisCancer, Hypoxia, and Metabolism

Cited by 67

Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65

Hwang, S.-K., Baker, A. R., Young, M. R., & Colburn, N. H. (2014) · Carcinogenesis

NF-κB Signaling PathwaysSignaling Pathways in Disease

Cited by 49

Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice

Hwang, S.-K., Jin, H., Kwon, J. T., Chang, S.-H., Kim, T. H., Cho, C.-S., Lee, K. H., Young, M. R., Colburn, N. H., Beck, G. R., et al. (2007) · Gene Therapy

RNA Interference and Gene DeliveryInhalation and Respiratory Drug Delivery

Cited by 44

Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation

Schmid, T., Bajer, M. M., Blees, J. S., Eifler, L. K., Milke, L., Rübsamen, D., Schulz, K., Weigert, A., Baker, A. R., Colburn, N. H., et al. (2011) · Carcinogenesis

Immune cells in cancerCancer-related Molecular Pathways

Cited by 39

Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment

Yasuda, M., Schmid, T., Rübsamen, D., Colburn, N. H., Irie, K., & Murakami, A. (2010) · Molecular Carcinogenesis

Immune cells in cancerCell death mechanisms and regulation

Cited by 33