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mTORC2 Activity Is Elevated in Gliomas and Promotes Growth and Cell Motility via Overexpression of Rictor

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Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors

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TORC2 Structure and Function

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Structural basis for translational inhibition by the tumour suppressor Pdcd4

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Crystal structure of the eIF4A–PDCD4 complex

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Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer

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Tumor Suppressor PDCD4 Represses Internal Ribosome Entry Site-Mediated Translation of Antiapoptotic Proteins and Is Regulated by S6 Kinase 2

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Downregulation of E-cadherin is an essential event in activating β-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells

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Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein

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Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo

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Programmed Cell Death 4 inhibits breast cancer cell invasion by increasing Tissue Inhibitor of Metalloproteinases-2 expression

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Therapeutic Potential of the Translation Inhibitor Silvestrol in Hepatocellular Cancer

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Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion

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Chapter 11 Monitoring Mammalian Target of Rapamycin (mTOR) Activity

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Tumour Suppressive Function and Modulation of Programmed Cell Death 4 (PDCD4) in Ovarian Cancer

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PDCD4 inhibits the malignant phenotype of ovarian cancer cells

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The mTOR (Mammalian Target of Rapamycin) Kinase Maintains Integrity of mTOR Complex 2

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SIN1 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial‐mesenchymal transition

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Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc

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AKT Activation by Pdcd4 Knockdown Up-Regulates Cyclin D1 Expression and Promotes Cell Proliferation

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An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4

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Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells

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Down-regulation of programmed cell death 4 leads to epithelial to mesenchymal transition and promotes metastasis in mice

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Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line

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Regulation and metabolic functions of mTORC1 and mTORC2.

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Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer

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Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions

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Protein translation: biological processes and therapeutic strategies for human diseases

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MiR-340-5p alleviates oxygen-glucose deprivation/reoxygenation-induced neuronal injury via PI3K/Akt activation by targeting PDCD4

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Programmed cell death 4 as an endogenous suppressor of BDNF translation is involved in stress-induced depression

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Linc00472 suppresses proliferation and promotes apoptosis through elevating PDCD4 expression by sponging miR-196a in colorectal cancer

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IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas

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The mechanisms and clinical significance of PDCD4 in colorectal cancer

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Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal Cancer

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Dissecting the Roles of PDCD4 in Breast Cancer

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The Regulatory Role of Non-coding RNAs on Programmed Cell Death Four in Inflammation and Cancer

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Ssc-miR-21-5p regulates endometrial epithelial cell proliferation, apoptosis and migration via the PDCD4/AKT pathway

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Stress granules in colorectal cancer: Current knowledge and potential therapeutic applications

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PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses

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Targeting translation regulators improves cancer therapy.

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Sin1-mediated mTOR signaling in cell growth, metabolism and immune response

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Curcumin exerts its antitumor effects in a context dependent fashion

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Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation

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miR-182 contributes to cell adhesion-mediated drug resistance in multiple myeloma via targeting PDCD4

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Nitidine Chloride Inhibits SIN1 Expression in Osteosarcoma Cells

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EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis.

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CD46 splice variant enhances translation of specific mRNAs linked to an aggressive tumor cell phenotype in bladder cancer

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Deoxynivalenol induces structural alterations in epidermoid carcinoma cells A431 and impairs the response to biomechanical stimulation

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circ-NOL10 regulated by MTDH/CASC3 inhibits breast cancer progression and metastasis via multiple miRNAs and PDCD4

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Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy

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Circ_0003266 sponges miR-503-5p to suppress colorectal cancer progression via regulating PDCD4 expression

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The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer

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Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit

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c-Jun N-terminal kinase (JNK)–mediated induction of mSin1 expression and mTORC2 activation in mesenchymal cells during fibrosis

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Pdcd4 promotes lipid deposition by attenuating PPARα-mediated fatty acid oxidation in hepatocytes

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Unmasking the tumourigenic role of SIN1/MAPKAP1 in the mTOR complex 2

Ezine, E., Lebbé, C., & Dumaz, N. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1464 · Cited by 14 · see citing works

PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs

Haas, A., Nilges, B. S., Leidel, S. A., & Klempnauer, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-59678-w · Cited by 14 · see citing works

MicroRNA-183-5p contributes to malignant progression through targeting PDCD4 in human hepatocellular carcinoma

Duan, X., Li, W., Hu, P., Jiang, B., Yang, J., Zhou, L., Mao, X., & Tian, B. (2020) · Bioscience Reports · doi:10.1042/bsr20201761 · Cited by 13 · see citing works

Advances in the study of the relationship between Porphyromonas gingivalis and various diseases

Zou, Q., Xie, H., Yang, W., Xu, J., Ying, S., Liao, X., Xie, J. H., Wu, X., & Meng, F. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1480233 · Cited by 12 · see citing works

Sin1 promotes proliferation and invasion of prostate cancer cells by modulating mTORC2-AKT and AR signaling cascades

Huang, Y., Feng, G., Cai, J., Peng, Q., Yang, Z., Yan, C., Yang, L., & Wang, Z. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117449 · Cited by 12 · see citing works

Silvestrol, a potent anticancer agent with unfavourable pharmacokinetics: Current knowledge on its pharmacological properties and future directions for the development of novel drugs

Peron, G., Mastinu, A., Peña‐Corona, S. I., Hernández‐Parra, H., Leyva‐Gómez, G., Călina, D. C., & Sharifi‐Rad, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117047 · Cited by 11 · see citing works

Neuronal activity regulates the nuclear proteome to promote activity-dependent transcription

Herbst, W. A., Deng, W., Wohlschlegel, J. A., Achiro, J. M., & Martin, K. C. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202103087 · Cited by 11 · see citing works

The Impact of Pdcd4, a Translation Inhibitor, on Drug Resistance

Wang, Q., & Yang, H. (2024) · Pharmaceuticals · doi:10.3390/ph17101396 · Cited by 10 · see citing works

The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane

Li, M.-L., Ragupathi, A., Patel, N., Hernandez, T., Magsino, J., Werlen, G., Brewer, G., & Jacinto, E. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102437 · Cited by 10 · see citing works

G-Protein-Coupled Estrogen Receptor 1 Promotes Gender Disparities in Hepatocellular Carcinoma via Modulation of SIN1 and mTOR Complex 2 Activity

Feng, G., Cai, J., Huang, Y., Zhu, X., Gong, B., Yang, Z., Yan, C., Hu, Z., Yang, L., & Wang, Z. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0173 · Cited by 9 · see citing works

PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson’s disease

Cao, B., Chen, X., Li, Y., Zhou, T., Chen, N., Guo, Y., Zhao, M., Guo, C., Shi, Y., Wang, Q., et al. (2024) · npj Parkinson's Disease · doi:10.1038/s41531-024-00760-9 · Cited by 8 · see citing works

Atg7 senses ATP levels and regulates AKT1-PDCD4 phosphorylation-ubiquitination axis to promote survival during metabolic stress

Deng, C., Li, C., Dong, X. D., Yu, Y., Guo, W., Guan, Y., Sun, X., & Cao, L. (2023) · Communications Biology · doi:10.1038/s42003-023-05656-7 · Cited by 8 · see citing works

Role of mammalian target of rapamycin complex 2 in primary and secondary liver cancer

Joechle, K., Guenzle, J., Hellerbrand, C., Strnad, P., Cramer, T., Neumann, U. P., & Lang, S. A. (2021) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v13.i11.1632 · Cited by 8 · see citing works

Tumor Suppressor p53 Down-Regulates Programmed Cell Death Protein 4 (PDCD4) Expression

Yang, W. H., George, A. P., Wang, C., Yang, R. H., Duncan, A. M., Patel, D., Neil, Z. D., & Yang, W. (2023) · Current Oncology · doi:10.3390/curroncol30020124 · Cited by 6 · see citing works

Discovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients

Bartkowiak, K., Mohammadi, P. M., Nissen, P., Werner, S., Agorku, D., Andreas, A., Geffken, M., Peine, S., Verpoort, K., Deutsch, T. M., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-87122-4 · Cited by 5 · see citing works

Translational Inhibition of Slug by Pdcd4 Contributes to Invasion Inhibition in Colorectal Cancer Cells

Wang, Q., He, W., Han, S., Li, M., Wang, Y., Zaytseva, Y. Y., Chen, L., Zhu, J., & Yang, H. (2025) · Cancer Medicine · doi:10.1002/cam4.71145 · Cited by 2 · see citing works

Induction of premature senescence and a less-fibrogenic phenotype by programmed cell death 4 knockdown in the human hepatic stellate cell line Lieming Xu-2

Perveen, R., Ozaki, I., Manirujjaman, M., Mine, K., Murata, Y., Tanaka, K., Xia, J., Takahashi, H., Anzai, K., & Matsuhashi, S. (2022) · Human Cell · doi:10.1007/s13577-022-00844-9 · Cited by 3 · see citing works

Low PDCD4 Expression Is Associated With Poor Prognosis of Colorectal Carcinoma

Kim, J. Y., Lee, H., Kim, E., Lee, W. M., Hong, Y. O., & Hong, S. A. (2021) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000000948 · Cited by 3 · see citing works

L-3,4-Dihydroxy-6-[18F]fluorophenylalanine

Leung, K. (2011) · Europe PMC (PubMed Central) · Cited by 2 · see citing works

In vitro study to evaluate the effect of granulocyte colony stimulating factor on colorectal adenocarcinoma and on mesenchymal stem cells trans differentiation into cancer stem cells by cancer cells derived exosomes

Ahmed, A. A., Monir, M., Sabry, D., & Mostafa, A. (2023) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-023-00351-2 · Cited by 1 · see citing works

Mutant NPM1 modulates PDCD4 ubiquitination degradation and facilitates leukemogenesis

Liang, C., Ke, J., Zhang, Z., Guo, H., Shang, H., Liu, D., Li, S., & Wu, F. (2025) · iScience · doi:10.1016/j.isci.2025.113776 · Cited by 1 · see citing works

Knockdown of programmed cell death 4 inhibits endoplasmic reticulum stress in male mice with intracerebral hemorrhage through the phosphoinositide 3-kinase/protein kinase B pathway

Qi, J., Zhang, Z., Yin, J., Yuan, X., Wang, X., Liu, Z., Liu, Y., & Wang, J. (2026) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2026.108554 · Cited by 1 · see citing works

Role of PDCD4 in inflammation and tumors: a double-edged sword

Jia, Y., Chen, X., & Zhang, L. (2018) · Scientia Sinica Vitae · doi:10.1360/n052018-00164

NOVEL COMPUTATIONAL METHODS FOR CANCER GENOMICS DATA ANALYSIS

Liu, J. (2021) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2021.215

Faculty Opinions recommendation of Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer.

Cole, M., & Schaafsma, E. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738541400.793579087

Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in 40S small ribosomal subunitPreprint

Querido, J. B., Sokabe, M., Díaz‐López, I., Gordiyenko, Y., Zuber, P. K., Du, Y., Albacete-Albacete, L., Ramakrishnan, V., & Fraser, C. S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.01.592117

Silencing PDCD4 Mediates Transcription Factor EB Overexpression Promoting Proliferation, Migration, and Invasion of Cervical Cancer Hela Cells

Gao, X. Y., Liang, Z., Yuan, Y., & Liu, W. (2024) · Science of Advanced Materials · doi:10.1166/sam.2024.4636

Phosphorylation of USP33 by CDK1 stabilizes the mTORC2 component SIN1

Wen, Y., Zhang, C., Liang, M., Yang, X. J., Zeng, H., Wan, R., Ma, X., Huang, L., Li, M., Zhang, Q., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07869-6

PDCD4: A Double-Edged Sword in Neurological Diseases

Li, C., Zheng, K., Qiu, M. S., & Yang, J. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05768-1

La fonction suppresseur de tumeur de la protéine adaptatrice SLAP dans le cancer colorectal implique la régulation de la signalisation mTORC2

Mevizou, R. (2021) · doi:10.70675/baa79427z3972z46a0zbf49zb12b1554e87f

Exosomal miR-373-3p Derived from Docetaxel-Resistant Lung Cancer Cells Targets PDCD4 to Promote Proliferation and Inhibit Apoptosis in Lung Cancer Cells

Yuan, Y., Zhu, B., Yang, L., Leng, Y., Chen, F., Yang, Z., Gu, W., & Zhang, K. (2026) · Biomedicines · doi:10.3390/biomedicines14050986

Pdcd4–Rictor interaction suppresses mTORC2-PFKFB3 axis and tumorigenesis in NSCLC

Wang, Q., Xin, Y., Zokaei, E., Zeng, L., Piecoro, D. W., Chen, M., Zhang, Y., Yang, K. S., Wang, C., Liu, X., et al. (2026) · Neoplasia · doi:10.1016/j.neo.2026.101354

Abstract LB-032: Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma

Wang, Q., Zhu, J., & Yang, H. (2017) · Cancer Research · doi:10.1158/1538-7445.am2017-lb-032

Translational Inhibition of Slug by Pdcd4 Contributes to Invasion Inhibition in Colorectal Cancer Cells

Wang, Q., He, W., Han, S., Li, M., Wang, Y., Zaytseva, Y. Y., Chen, L., Zhu, J., & Yang, H. (2025) · Cancer Medicine · doi:10.1002/cam4.71145 · Cited by 2 · see citing works

Abstract 2901: Pdcd4 inhibits slug translation to suppress E-cadherin expression and invasion in colon tumor cells

Wang, Q., Zhu, J., & Yang, H. (2021) · Cancer Research · doi:10.1158/1538-7445.am2021-2901

Abstract 3079: Identification of the translational targets of tumor suppressor Pdcd4

Yoshikawa, N., Young, M. R., Hegamyer, G. A., Baker, A. R., Santhanam, A. N., Wei, Q., & Colburn, N. H. (2011) · Cancer Research · doi:10.1158/1538-7445.am2011-3079

Downregulation of E-cadherin is an essential event in activating β-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells

Wang, Q., Sun, Z. X., Allgayer, H., & Yang, H. S. (2010) · Oncogene · doi:10.1038/onc.2009.302 · Cited by 89 · see citing works