Efeyan, Alejo

mTOR: from growth signal integration to cancer, diabetes and ageing

Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 3,941

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase

Zoncu, R., Bar-Peled, L., Efeyan, A., Wang, S., Sancak, Y., & Sabatini, D. M. (2011) · Science

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 1,673

Senescence in premalignant tumours

Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 1,482

Nutrient-sensing mechanisms and pathways

Efeyan, A., Comb, W. C., & Sabatini, D. M. (2015) · Nature

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 1,110

Amino acids and mTORC1: from lysosomes to disease

Efeyan, A., Zoncu, R., & Sabatini, D. M. (2012) · Trends in Molecular Medicine

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 436

Pten positively regulates brown adipose function, energy expenditure, and longevity

Ortega-Molina, A., Efeyan, A., Lopez-Guadamillas, E., Muñoz-Martin, M., Gómez-López, G., Cañamero, M., Mulero, F., Pastor, J., Martinez, S., Romanos, E., et al. (2012) · Cell Metabolism

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 356

Induction of p53-Dependent Senescence by the MDM2 Antagonist Nutlin-3a in Mouse Cells of Fibroblast Origin

Efeyan, A., Ortega-Molina, A., Velasco-Miguel, S., Herranz, D., Vassilev, L. T., & Serrano, M. (2007) · Cancer Research

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 140

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses

Lesbats, J., Brillac, A., Reisz, J. A., Mukherjee, P., Lhuissier, C., Fernández-Monreal, M., Dupuy, J.-W., Sequeira, A., Tioli, G., De La Calle Arregui, C., et al. (2025) · Nature

Phagocytosis and Immune RegulationImmune Response and Inflammation

Cited by 74

Hepatic nutrient and hormone signaling to mTORC1 instructs the postnatal metabolic zonation of the liver

Plata-Gómez, A. B., de Prado-Rivas, L., Sanz, A., Deleyto-Seldas, N., García, F., de la Calle Arregui, C., Silva, C., Caleiras, E., Graña-Castro, O., Piñeiro-Yáñez, E., et al. (2024) · Nature Communications

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

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