Kerr, William G.

TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1

Peng, Q., Malhotra, S., Torchia, J. A., Kerr, W. G., Coggeshall, K. M., & Humphrey, M. B. (2010) · Science Signaling

Bone Metabolism and DiseasesPhagocytosis and Immune Regulation

Cited by 413

A Critical Role for Stat3 Signaling in Immune Tolerance

Cheng, F., Wang, H.-W., Cuenca, A., Huang, M., Ghansah, T., Brayer, J., Kerr, W. G., Takeda, K., Akira, S., Schoenberger, S. P., et al. (2003) · Immunity

T-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

Cited by 377

Influence of SHIP on the NK Repertoire and Allogeneic Bone Marrow Transplantation

Wang, J.-W., Howson, J. M., Ghansah, T., Desponts, C., Ninos, J. M., May, S. L., Nguyen, K. H. T., Toyama-Sorimachi, N., & Kerr, W. G. (2002) · Science

Immune Cell Function and InteractionHematopoietic Stem Cell Transplantation

Cited by 178

SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells

Brooks, R., Fuhler, G. M., Iyer, S., Smith, M. J., Park, M.-Y., Paraiso, K. H. T., Engelman, R. W., & Kerr, W. G. (2010) · The Journal of Immunology

T-cell and B-cell ImmunologyHematopoietic Stem Cell Transplantation

Cited by 140

The Next Generation of Immunotherapy for Cancer: Small Molecules Could Make Big Waves

Kerr, W. G., & Chisholm, J. D. (2019) · The Journal of Immunology

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 131

Therapeutic Potential of SH2 Domain-Containing Inositol-5′-Phosphatase 1 (SHIP1) and SHIP2 Inhibition in Cancer

Fuhler, G. M., Brooks, R., Toms, B., Iyer, S., Gengo, E. A., Park, M.-Y., Gumbleton, M., Viernes, D. R., Chisholm, J. D., & Kerr, W. G. (2012) · Molecular Medicine

PI3K/AKT/mTOR signaling in cancerProtein Tyrosine Phosphatases

Cited by 109

Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis

Pedicone, C., Fernandes, S., Dungan, O. M., Dormann, S. M., Viernes, D. R., Adhikari, A. A., Choi, L. B., De Jong, E. P., Chisholm, J. D., & Kerr, W. G. (2020) · Journal of Cell Science

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 61

Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival

Gumbleton, M., Sudan, R., Fernandes, S., Engelman, R. W., Russo, C. M., Chisholm, J. D., & Kerr, W. G. (2017) · Science Signaling

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 43

Targeting SHIP1 and SHIP2 in Cancer

Pedicone, C., Meyer, S. T., Chisholm, J. D., & Kerr, W. G. (2021) · Cancers

Protein Tyrosine PhosphatasesPI3K/AKT/mTOR signaling in cancer

Cited by 42

Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus

Matera, A., Compagnion, A.-C., Pedicone, C., Kotah, J. M., Ivanov, A., Monsorno, K., Labouèbe, G., Leggio, L., Pereira-Iglesias, M., Beule, D., et al. (2025) · Immunity

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 34

Coordinate Expansion of Murine Hematopoietic and Mesenchymal Stem Cell Compartments by SHIPi

Brooks, R., Iyer, S., Akada, H., Neelam, S., Russo, C. M., Chisholm, J. D., & Kerr, W. G. (2015) · Stem Cells

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 32

Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia

Pedicone, C., Fernandes, S., Matera, A., Meyer, S. T., Loh, S., Ha, J.-H., Bernard, D., Chisholm, J. D., Paolicelli, R. C., & Kerr, W. G. (2022) · iScience

Neuroinflammation and Neurodegeneration MechanismsProtein Tyrosine Phosphatases

Cited by 26

SHIP inhibition mediates select TREM2-induced microglial functions

Ramakrishnan, G. S., Berry, W. L., Pacherille, A., Kerr, W. G., Chisholm, J. D., Pedicone, C., & Humphrey, M. B. (2024) · Molecular Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 17

Assessing Inflammatory Disease at Mucosal Surfaces in Murine Genetic Models

Engelman, R. W., & Kerr, W. G. (2012) · Methods in Molecular Biology

Asthma and respiratory diseasesInflammatory Bowel Disease

Cited by 7