Zheng, Ning

Mechanism of auxin perception by the TIR1 ubiquitin ligase

Tan, X., Calderon-Villalobos, L. I. A., Sharon, M., Zheng, C., Robinson, C. V., Estelle, M., & Zheng, N. (2007) · Nature

Plant Molecular Biology ResearchLight effects on plants

Cited by 1,688

Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

Zheng, N., Schulman, B. A., Song, L., Miller, J. J., Jeffrey, P. D., Wang, P., Chu, C., Koepp, D. M., Elledge, S. J., Pagano, M., et al. (2002) · Nature

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 1,507

Ubiquitin ligases: structure, function, and regulation

Zheng, N., & Shabek, N. (2017) · Annual Review of Biochemistry

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 1,499

Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor

Sheard, L. B., Tan, X., Mao, H., Withers, J., Ben-Nissan, G., Hinds, T. R., Kobayashi, Y., Hsu, F.-F., Sharon, M., Browse, J., et al. (2010) · Nature

Plant Molecular Biology ResearchInsect-Plant Interactions and Control

Cited by 1,497

D14–SCFD3-dependent degradation of D53 regulates strigolactone signalling

Zhou, F., Lin, Q., Zhu, L., Ren, Y., Zhou, K., Shabek, N., Wu, F., Mao, H., Dong, W., Gan, L., et al. (2013) · Nature

Plant Parasitism and ResistancePlant Molecular Biology Research

Cited by 891

Structure of a c-Cbl–UbcH7 Complex

Zheng, N., Wang, P., Jeffrey, P. D., & Pavletich, N. P. (2000) · Cell

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 839

Molecular architecture and assembly of the DDB1–CUL4A ubiquitin ligase machinery

Angers, S., Li, T., Yi, X., MacCoss, M. J., Moon, R. T., & Zheng, N. (2006) · Nature

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 674

The KLHL12–Cullin-3 ubiquitin ligase negatively regulates the Wnt–β-catenin pathway by targeting Dishevelled for degradation

Angers, S., Thorpe, C. J., Biechele, T. L., Goldenberg, S. J., Zheng, N., MacCoss, M. J., & Moon, R. T. (2006) · Nature Cell Biology

Wnt/β-catenin signaling in development and cancerUbiquitin and proteasome pathways

Cited by 364

Structure of the Cand1-Cul1-Roc1 Complex Reveals Regulatory Mechanisms for the Assembly of the Multisubunit Cullin-Dependent Ubiquitin Ligases

Goldenberg, S. J., Cascio, T. C., Shumway, S. D., Garbutt, K. C., Liu, J., Xiong, Y., & Zheng, N. (2004) · Cell

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 280

Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins

Pierce, N. W., Lee, J. E., Liu, X., Sweredoski, M. J., Graham, R. L. J., Larimore, E. A., Rome, M., Zheng, N., Clurman, B. E., Hess, S., et al. (2013) · Cell

Ubiquitin and proteasome pathwaysMicrotubule and mitosis dynamics

Cited by 262

An artificial intelligence accelerated virtual screening platform for drug discovery

Zhou, G., Rusnac, D.-V., Park, H., Canzani, D., Nguyen, H. M., Stewart, L., Bush, M. F., Nguyen, P. T., Wulff, H., Yarov-Yarovoy, V., et al. (2024) · Nature Communications

Computational Drug Discovery Methodsvaccines and immunoinformatics approaches

Cited by 260

SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket

Xing, W., Busino, L., Hinds, T. R., Marionni, S. T., Saifee, N. H., Bush, M. F., Pagano, M., & Zheng, N. (2013) · Nature

Circadian rhythm and melatoninLight effects on plants

Cited by 234

Structural assembly of cullin-RING ubiquitin ligase complexes

Zimmerman, E. S., Schulman, B. A., & Zheng, N. (2010) · Current Opinion in Structural Biology

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 227

Structural regulation of cullin-RING ubiquitin ligase complexes

Duda, D. M., Scott, D. C., Calabrese, M. F., Zimmerman, E. S., Zheng, N., & Schulman, B. A. (2011) · Current Opinion in Structural Biology

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 205

Auxin Perception--Structural Insights

Calderon-Villalobos, L. I., Tan, X., Zheng, N., & Estelle, M. (2010) · Cold Spring Harbor Perspectives in Biology

Plant Molecular Biology ResearchLight effects on plants

Cited by 177

Modulation of Phototropic Responsiveness in Arabidopsis through Ubiquitination of Phototropin 1 by the CUL3-Ring E3 Ubiquitin Ligase CRL3NPH3

Roberts, D., Pedmale, U. V., Morrow, J., Sachdev, S., Lechner, E., Tang, X., Zheng, N., Hannink, M., Genschik, P., & Liscum, E. (2011) · The Plant Cell

Light effects on plantsPlant Molecular Biology Research

Cited by 150

Cancer-Derived Mutations in KEAP1 Impair NRF2 Degradation but not Ubiquitination

Hast, B. E., Cloer, E. W., Goldfarb, D., Li, H., Siesser, P. F., Yan, F., Walter, V., Zheng, N., Hayes, D. N., & Major, M. B. (2014) · Cancer Research

Genomics, phytochemicals, and oxidative stressUbiquitin and proteasome pathways

Cited by 138

Defining molecular glues with a dual-nanobody cannabidiol sensor

Cao, S., Kang, S., Mao, H., Yao, J., Gu, L., & Zheng, N. (2022) · Nature Communications

Protein Degradation and InhibitorsBiochemical and Structural Characterization

Cited by 125

Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase

Rusnac, D.-V., Lin, H.-C., Canzani, D., Tien, K. X., Hinds, T. R., Tsue, A. F., Bush, M. F., Yen, H.-C. S., & Zheng, N. (2018) · Molecular Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 93

UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

Yeo, M. J. R., Zhang, O., Xie, X., Nam, E., Payne, N. C., Gosavi, P. M., Kwok, H. S., Iram, I., Lee, C., Li, J., et al. (2025) · Nature

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 58

Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations

Xie, X., Zhang, O., Yeo, M. J. R., Lee, C., Tao, R., Harry, S. A., Payne, N. C., Nam, E., Paul, L., Li, Y., et al. (2025) · Nature

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 50

Scribble co-operatively binds multiple α1D-adrenergic receptor C-terminal PDZ ligands

Janezic, E. M., Harris, D.-A., Dinh, D., Lee, K.-S., Stewart, A., Hinds, T. R., Hsu, P. L., Zheng, N., & Hague, C. (2019) · Scientific Reports

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 15

Degronomics: Mapping the Interacting Peptidome of a Ubiquitin Ligase Using an Integrative Mass Spectrometry Strategy

Canzani, D., Rusnac, D.-V., Zheng, N., & Bush, M. F. (2019) · Analytical Chemistry

Ubiquitin and proteasome pathwaysAdvanced Proteomics Techniques and Applications

Cited by 11