Gradinaru, Viviana

Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease

Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell

Parkinson's Disease Mechanisms and TreatmentsGut microbiota and health

Cited by 3,622

Structural and molecular interrogation of intact biological systems

Chung, K., Wallace, J., Kim, S.-Y., Kalyanasundaram, S., Andalman, A. S., Davidson, T. J., Mirzabekov, J. J., Zalocusky, K. A., Mattis, J., Denisin, A. K., et al. (2013) · Nature

Advanced Fluorescence Microscopy TechniquesCell Image Analysis Techniques

Cited by 2,008

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

Chan, K. Y., Jang, M. J., Yoo, B. B., Greenbaum, A., Ravi, N., Wu, W.-L., Sánchez-Guardado, L., Lois, C., Mazmanian, S. K., Deverman, B. E., et al. (2017) · Nature Neuroscience

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 1,578

Amygdala circuitry mediating reversible and bidirectional control of anxiety

Tye, K. M., Prakash, R., Kim, S.-Y., Fenno, L. E., Grosenick, L., Zarabi, H., Thompson, K. R., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2011) · Nature

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 1,289

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

Deverman, B. E., Pravdo, P. L., Simpson, B. P., Kumar, S. R., Chan, K. Y., Banerjee, A., Wu, W.-L., Yang, B., Huber, N., Pasca, S. P., et al. (2016) · Nature Biotechnology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 1,061

Negative feedback control of neuronal activity by microglia

Badimon, A., Strasburger, H. J., Ayata, P., Chen, X., Nair, A., Ikegami, A., Hwang, P., Chan, A. T., Graves, S. M., Uweru, J. O., et al. (2020) · Nature

Neuroinflammation and Neurodegeneration MechanismsAdenosine and Purinergic Signaling

Cited by 979

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins

Mattis, J., Tye, K. M., Ferenczi, E. A., Ramakrishnan, C., O'Shea, D. J., Prakash, R., Gunaydin, L. A., Hyun, M., Fenno, L. E., Gradinaru, V., et al. (2012) · Nature Methods

Photoreceptor and optogenetics researchAdvanced Fluorescence Microscopy Techniques

Cited by 780

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures

Zhang, F., Gradinaru, V., Adamantidis, A. R., Durand, R., Airan, R. D., de Lecea, L., & Deisseroth, K. (2010) · Nature Protocols

Photoreceptor and optogenetics researchNeuroscience and Neuropharmacology Research

Cited by 692

Molecular basis of astrocyte diversity and morphology across the CNS in health and disease

Endo, F., Kasai, A., Soto, J. S., Yu, X., Qu, Z., Hashimoto, H., Gradinaru, V., Kawaguchi, R., & Khakh, B. S. (2022) · Science

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 560

LRP1 is a master regulator of tau uptake and spread

Rauch, J. N., Luna, G., Guzman, E., Audouard, M., Challis, C., Sibih, Y. E., Leshuk, C., Hernandez, I., Wegmann, S., Hyman, B. T., et al. (2020) · Nature

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 541

Cholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning

Witten, I. B., Lin, S.-C., Brodsky, M., Prakash, R., Diester, I., Anikeeva, P., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2010) · Science

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 467

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

Sampson, T. R., Challis, C., Jain, N., Moiseyenko, A., Ladinsky, M. S., Shastri, G. G., Thron, T., Needham, B. D., Horvath, I., Debelius, J. W., et al. (2020) · eLife

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 439

AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset

Goertsen, D., Flytzanis, N. C., Goeden, N., Chuapoco, M. R., Cummins, A., Chen, Y., Fan, Y., Zhang, Q., Sharma, J., Duan, Y., et al. (2022) · Nature Neuroscience

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 420

Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice

Challis, C., Hori, A., Sampson, T. R., Yoo, B. B., Challis, R. C., Hamilton, A. M., Mazmanian, S. K., Volpicelli-Daley, L. A., & Gradinaru, V. (2020) · Nature Neuroscience

Parkinson's Disease Mechanisms and TreatmentsLysosomal Storage Disorders Research

Cited by 405

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

Pan, M., Reid, M. A., Lowman, X. H., Kulkarni, R. P., Tran, T. Q., Liu, X., Yang, Y., Hernandez-Davies, J. E., Rosales, K. K., Li, H., et al. (2016) · Nature Cell Biology

Cancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation

Cited by 368

Bioelectronic medicines: a research roadmap

Birmingham, K., Gradinaru, V., Anikeeva, P., Grill, W. M., Pikov, V., McLaughlin, B., Pasricha, P., Weber, D., Ludwig, K., & Famm, K. (2014) · Nature Reviews Drug Discovery

Vagus Nerve Stimulation ResearchNeuroscience and Neural Engineering

Cited by 322

Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli

Cho, J. R., Treweek, J. B., Robinson, J. E., Xiao, C., Bremner, L. R., Greenbaum, A., & Gradinaru, V. (2017) · Neuron

Sleep and Wakefulness ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 276

The Jellyfish Cassiopea Exhibits a Sleep-like State

Nath, R. D., Bedbrook, C. N., Abrams, M. J., Basinger, T., Bois, J. S., Prober, D. A., Sternberg, P. W., Gradinaru, V., & Goentoro, L. (2017) · Current Biology

Marine Invertebrate Physiology and EcologySleep and Wakefulness Research

Cited by 260

Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

Mich, J. K., Graybuck, L. T., Hess, E. E., Mahoney, J. T., Kojima, Y., Ding, Y., Somasundaram, S., Miller, J. A., Kalmbach, B. E., Radaelli, C., et al. (2021) · Cell Reports

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 193

Enhancer viruses for combinatorial cell-subclass-specific labeling

Graybuck, L. T., Daigle, T. L., Sedeño-Cortés, A. E., Walker, M., Kalmbach, B., Lenz, G. H., Morin, E., Nguyen, T. N., Garren, E., Bendrick, J. L., et al. (2021) · Neuron

Virus-based gene therapy researchSingle-cell and spatial transcriptomics

Cited by 187

Viral Strategies for Targeting the Central and Peripheral Nervous Systems

Bedbrook, C. N., Deverman, B. E., & Gradinaru, V. (2018) · Annual Review of Neuroscience

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 168

Adeno-Associated Virus Toolkit to Target Diverse Brain Cells

Challis, R. C., Ravindra Kumar, S., Chen, X., Goertsen, D., Coughlin, G. M., Hori, A. M., Chuapoco, M. R., Otis, T. S., Miles, T. F., & Gradinaru, V. (2022) · Annual Review of Neuroscience

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 148

A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice

Abdel-Haq, R., Schlachetzki, J. C., Boktor, J. C., Cantu-Jungles, T. M., Thron, T., Zhang, M., Bostick, J. W., Khazaei, T., Chilakala, S., Morais, L. H., et al. (2022) · eLife

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 82

Primate-conserved Carbonic Anhydrase IV and murine-restricted Ly6c1 are new targets for crossing the blood-brain barrier

Shay, T. F., Sullivan, E. E., Ding, X., Chen, X., Kumar, S. R., Goertsen, D., Brown, D., Vielmetter, J., Borsos, M., Lam, A. W., et al. (2023) · Science Advances

Barrier Structure and Function StudiesVirus-based gene therapy research

Cited by 67