Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures

The Mouse Brain in Stereotaxic Coordinates

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Millisecond-timescale, genetically targeted optical control of neural activity

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Channelrhodopsin-2, a directly light-gated cation-selective membrane channel

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Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

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Multimodal fast optical interrogation of neural circuitry

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Optical Deconstruction of Parkinsonian Neural Circuitry

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Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

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Neural substrates of awakening probed with optogenetic control of hypocretin neurons

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Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

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Monosynaptic Restriction of Transsynaptic Tracing from Single, Genetically Targeted Neurons

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The subcellular organization of neocortical excitatory connections

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Light Activation of Channelrhodopsin-2 in Excitable Cells of Caenorhabditis elegans Triggers Rapid Behavioral Responses

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An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology

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Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections

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Untitled work

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Next-Generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits

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Ectopic Expression of a Microbial-Type Rhodopsin Restores Visual Responses in Mice with Photoreceptor Degeneration

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Ultrafast optogenetic control

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In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2

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Genetic Dissection of Neural Circuits

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Temporally precise in vivo control of intracellular signalling

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Characterization of Engineered Channelrhodopsin Variants with Improved Properties and Kinetics

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Channelrhodopsin-2 and optical control of excitable cells

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Circuit-breakers: optical technologies for probing neural signals and systems

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VSDI: a new era in functional imaging of cortical dynamics

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A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping

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Bi-stable neural state switches

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Multiple-Color Optical Activation, Silencing, and Desynchronization of Neural Activity, with Single-Spike Temporal Resolution

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Light-Induced Activation of Distinct Modulatory Neurons Triggers Appetitive or Aversive Learning in Drosophila Larvae

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Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin

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Sparse optical microstimulation in barrel cortex drives learned behaviour in freely moving mice

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eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications

Gradinaru, V., Thompson, K. R., & Deisseroth, K. A. (2008) · Journal of Neurocytology · doi:10.1007/s11068-008-9027-6 · Cited by 537 · see citing works

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri

Zhang, F., Prigge, M., Beyrière, F., Tsunoda, S. P., Mattis, J., Yizhar, O., Hegemann, P., & Deisseroth, K. A. (2008) · Nature Neuroscience · doi:10.1038/nn.2120 · Cited by 526 · see citing works

Millisecond-Timescale Optical Control of Neural Dynamics in the Nonhuman Primate Brain

Han, X., Qian, X., Bernstein, J. G., Zhou, H., Franzesi, G. T., Stern, P., Bronson, R. T., Graybiel, A. M., Desimone, R., & Boyden, E. S. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.011 · Cited by 497 · see citing works

Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring <i>in vivo</i>

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Nociceptive Neurons Protect Drosophila Larvae from Parasitoid Wasps

Hwang, R. Y., Zhong, L., Xu, Y., Johnson, T., Zhang, F., Deisseroth, K. A., & Tracey, W. D. (2007) · Current Biology · doi:10.1016/j.cub.2007.11.029 · Cited by 483 · see citing works

Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight

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What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice

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Targeting and Readout Strategies for Fast Optical Neural ControlIn VitroandIn Vivo

Gradinaru, V., Thompson, K. R., Zhang, F., Mogri, M., Kay, K., Schneider, M. B., & Deisseroth, K. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3578-07.2007 · Cited by 466 · see citing works

Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area

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High-speed imaging reveals neurophysiological links to behavior in an animal model of depression

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High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice

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Kinetic evaluation of photosensitivity in genetically engineered neurons expressing green algae light-gated channels

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PINP: A New Method of Tagging Neuronal Populations for Identification during In Vivo Electrophysiological Recording

Lima, S. Q., Hromádka, T., Znamenskiy, P., & Zador, A. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006099 · Cited by 356 · see citing works

Stereotaxic gene delivery in the rodent brain

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Silencing preBötzinger Complex somatostatin-expressing neurons induces persistent apnea in awake rat

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Temporal Dynamics of Neuronal Activation by Channelrhodopsin-2 and TRPA1 Determine Behavioral Output inDrosophilaLarvae

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Generation of T-cell receptor retrogenic mice

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Escape Behavior Elicited by Single, Channelrhodopsin-2-Evoked Spikes in Zebrafish Somatosensory Neurons

Douglass, A. D., Kraves, S., Deisseroth, K. A., Schier, A. F., & Engert, F. (2008) · Current Biology · doi:10.1016/j.cub.2008.06.077 · Cited by 257 · see citing works

Transneuronal circuit tracing with neurotropic viruses

Callaway, E. M. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.03.007 · Cited by 252 · see citing works

Optical induction of synaptic plasticity using a light-sensitive channel

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Physiological Properties of Hypothalamic MCH Neurons Identified with Selective Expression of Reporter Gene after Recombinant Virus Infection

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Use of voltage-sensitive dyes and optical recordings in the central nervous system

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Improved expression of halorhodopsin for light-induced silencing of neuronal activity

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Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue

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Translational Efficiency of EMCV IRES in Bicistronic Vectors is Dependent Upon IRES Sequence and Gene Location

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Myosin-dependent targeting of transmembrane proteins to neuronal dendrites

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Light-Induced Rescue of Breathing after Spinal Cord Injury

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Faithful Expression of Multiple Proteins via 2A-Peptide Self-Processing: A Versatile and Reliable Method for Manipulating Brain Circuits

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Molecular Determinants Differentiating Photocurrent Properties of Two Channelrhodopsins from Chlamydomonas

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High-Resolution Labeling and Functional Manipulation of Specific Neuron Types in Mouse Brain by Cre-Activated Viral Gene Expression

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Optical induction of plasticity at single synapses reveals input-specific accumulation of αCaMKII

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Real-time imaging of evoked activity in local circuits of the salamander olfactory bulb

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Light Activation of an Innate Olfactory Avoidance Response in Drosophila

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Anterograde Transneuronal Viral Tracing of Central Viscerosensory Pathways in Rats

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Targeted gene delivery to telencephalic inhibitory neurons by directional in utero electroporation

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Transcranial optogenetic stimulation for functional mapping of the motor cortex

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Retrograde trans-synaptic transfer of green fluorescent protein allows the genetic mapping of neuronal circuits in transgenic mice

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Genetic Tracing Shows Segregation of Taste Neuronal Circuitries for Bitter and Sweet

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Genetically timed, activity-sensor and rainbow transsynaptic viral tools

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Paired-recordings from synaptically coupled cortical and hippocampal neurons in acute and cultured brain slices

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Long-Term, Selective Gene Expression in Developing and Adult Hippocampal Pyramidal Neurons Using FocalIn UteroElectroporation

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Distinct Subtypes of Cholecystokinin (CCK)-Containing Interneurons of the Basolateral Amygdala Identified Using a CCK Promoter-Specific Lentivirus

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Integration of light-controlled neuronal firing and fast circuit imaging

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Activity-Dependent Depression of Excitability and Calcium Transients in the Neurohypophysis Suggests a Model of “Stuttering Conduction”

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Combinatorial methods for refined neuronal gene targeting

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Optical imaging of long-lasting depolarization on burst stimulation in area CA1 of rat hippocampal slices.

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Using Light to Reinstate Respiratory Plasticity

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Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

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Optogenetics in neural systems

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The development and application of optogenetics

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Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain

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Control of sleep and wakefulness

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Input-specific control of reward and aversion in the ventral tegmental area

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Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations

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Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli

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Integration of optogenetics with complementary methodologies in systems neuroscience

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Activation of specific interneurons improves V1 feature selectivity and visual perception

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Targeting cells with single vectors using multiple-feature Boolean logic

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Repeated cortico-striatal stimulation generates persistent OCD-like behavior

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Experience-dependent modification of a central amygdala fear circuit

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Dorsal raphe neurons signal reward through 5-HT and glutamate

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An optogenetic toolbox designed for primates

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Construction of implantable optical fibers for long-term optogenetic manipulation of neural circuits

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DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS: Review: Dissecting OCD Circuits: Animals to Treatments

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A Reorganized GABAergic Circuit in a Model of Epilepsy: Evidence from Optogenetic Labeling and Stimulation of Somatostatin Interneurons

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A Flexible, Micro-Lens-Coupled LED Stimulator for Optical Neuromodulation

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Light‐Controlled Mammalian Cells and Their Therapeutic Applications in Synthetic Biology

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Optogenetic tools for microbial synthetic biology

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Optogenetic investigation of neural circuits underlying brain disease in animal models

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